Publications 1992 2016

  • 29 h-Index
  • 110 Article
  • 22 Conference contribution
  • 5 Chapter
2011
14 Citations

Identification of novel targets for breast cancer by exploring gene switches on a genome scale

Wu, M., Liu, L. & Chan, C. Nov 3 2011 In : BMC Genomics. 12, 547

Research output: Research - peer-reviewArticle

Neoplasm Genes
Genome
Breast Neoplasms
Neoplasms
Switch Genes
111 Citations

Micro RNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β novel targets in sporadic Alzheimer's disease

Geekiyanage, H. & Chan, C. Oct 12 2011 In : Journal of Neuroscience. 31, 41, p. 14820-14830 11 p.

Research output: Research - peer-reviewArticle

Serine C-Palmitoyltransferase
MicroRNAs
Amyloid
Alzheimer Disease
Ceramides

Model based surface design to incorporate the effect of soluble cues

Chan, C. & Baek, S. 2011 ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B ed. p. 1195-1196 2 p.

Research output: ResearchConference contribution

3 Citations

Molecular mechanism by which palmitate inhibits PKR autophosphorylation

Cho, H., Mukherjee, S., Palasuberniam, P., Pillow, L., Bilgin, B., Nezich, C., Walton, S. P., Feig, M. & Chan, C. Feb 15 2011 In : Biochemistry. 50, 6, p. 1110-1119 10 p.

Research output: Research - peer-reviewArticle

Palmitates
Phosphotransferases
Adenosine Triphosphate
Binding Sites
Proteins
6 Citations

Polyelectrolyte multilayer stamping in aqueous phase and non-contact mode

Mehrotra, S., Lee, I., Liu, C. & Chan, C. Aug 3 2011 In : Industrial and Engineering Chemistry Research. 50, 15, p. 8851-8858 8 p.

Research output: Research - peer-reviewArticle

Stamping
Polyelectrolytes
Multilayers
Substrates
Scaffolds
3 Citations

Synergy analysis reveals association between insulin signaling and desmoplakin expression in palmitate treated HepG2 cells

Wang, X., Nath, A., Yang, X., Portis, A., Walton, S. P. & Chan, C. Nov 23 2011 In : PLoS One. 6, 11, e28138

Research output: Research - peer-reviewArticle

palmitates
insulin
cells
Desmoplakins
Palmitates
2010
7 Citations

Cancer-drug associations: A complex system

Dalkic, E., Wang, X., Wright, N. & Chan, C. 2010 In : PLoS One. 5, 4, e10031

Research output: Research - peer-reviewArticle

Pharmaceutical Preparations
Neoplasms
drugs
neoplasms
Large scale systems
37 Citations

Cell adhesive behavior on thin polyelectrolyte multilayers: Cells attempt to achieve homeostasis of its adhesion energy

Mehrotra, S., Hunley, S. C., Pawelec, K. M., Zhang, L., Lee, I., Baek, S. & Chan, C. Aug 3 2010 In : Langmuir. 26, 15, p. 12794-12802 9 p.

Research output: Research - peer-reviewArticle

homeostasis
adhesives
adhesion
cells
energy
14 Citations

Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles

Portis, A. M., Carballo, G., Baker, G. L., Chan, C. & Walton, S. P. Sep 2010 In : Microscopy Research and Technique. 73, 9, p. 878-885 8 p.

Research output: Research - peer-reviewArticle

Confocal Microscopy
Nanoparticles
Small Interfering RNA
delivery
microscopy
46 Citations

Designing highly active siRNAs for therapeutic applications

Patrick Walton, S., Wu, M., Gredell, J. A. & Chan, C. Dec 2010 In : FEBS Journal. 277, 23, p. 4806-4813 8 p.

Research output: Research - peer-reviewArticle

Small Interfering RNA
Therapeutics
RNA Interference
RNA
Thermodynamics
2 Citations

Erratum: Time controlled protein release from layer-by-layer assembled multilayer functionalized agarose hydrogels (Advanced Functional Materials (2010) 20 (247) 10.1002/adfm.200901172)

Mehrotra, S., Lynam, D., Maloney, R., Pawelec, K. M., Tuszynski, M. H., Lee, I., Chan, C. & Sakamoto, J. Mar 24 2010 In : Advanced Functional Materials. 20, 6, p. 878 1 p.

Research output: Research - peer-reviewArticle

29 Citations
Cell Separation
Mesenchymal Stromal Cells
Stem cells
Rats
Hematopoietic Stem Cells
5 Citations
Cell Separation
Mesenchymal Stromal Cells
Stem cells
Rats
Hematopoietic Stem Cells
32 Citations

Recognition of siRNA asymmetry by TAR RNA binding protein

Gredell, J. A., Dittmer, M. J., Wu, M., Chan, C. & Walton, S. P. Apr 13 2010 In : Biochemistry. 49, 14, p. 3148-3155 8 p.

Research output: Research - peer-reviewArticle

Small Interfering RNA
trans-activation responsive RNA-binding protein
RNA-Induced Silencing Complex
RNA Interference
Proteins
24 Citations

Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells

Zhang, L., Seitz, L. C., Abramczyk, A. M. & Chan, C. Mar 10 2010 In : Experimental Cell Research. 316, 5, p. 716-727 12 p.

Research output: Research - peer-reviewArticle

Palmitates
Hep G2 Cells
Cell Death
Organelle Biogenesis
Reactive Oxygen Species
24 Citations

The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells

Yang, X., Nath, A., Opperman, M. J. & Chan, C. Oct 1 2010 In : Molecular Biology of the Cell. 21, 19, p. 3449-3458 10 p.

Research output: Research - peer-reviewArticle

eIF-2 Kinase
Insulin Receptor Substrate Proteins
Double-Stranded RNA
Hep G2 Cells
Phosphorylation
65 Citations

Time controlled protein release from layer-by-layer assembled multilayer functionalized agarose hydrogels

Mehrotra, S., Lynam, D., Maloney, R., Pawelec, K. M., Tuszynski, M. H., Lee, I., Chan, C. & Sakamoto, J. Jan 22 2010 In : Advanced Functional Materials. 20, 2, p. 247-258 12 p.

Research output: Research - peer-reviewArticle

Hydrogels
Sepharose
Multilayers
Proteins
proteins
30 Citations

Withanolide a and asiatic acid modulate multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearance

Patil, S. P., Maki, S., Khedkar, S. A., Rigby, A. C. & Chan, C. Jul 23 2010 In : Journal of Natural Products. 73, 7, p. 1196-1202 7 p.

Research output: Research - peer-reviewArticle

Withanolides
Amyloid beta-Protein Precursor
Amyloid beta-Peptides
Alzheimer Disease
asiatic acid
2009
21 Citations

A dynamic analysis of IRS-PKR signaling in liver cells: A discrete modeling approach

Wu, M., Yang, X. & Chan, C. 2009 In : PLoS One. 4, 12, e8040

Research output: Research - peer-reviewArticle

Liver
Dynamic analysis
hepatocytes
Insulin
insulin

Integrative analysis of cancer pathway progression and coherence

Dalkic, E., Walter Nash, D. E., Fassia, M. K. & Chan, C. 2009 In : Proteomics - Clinical Applications. 3, 4, p. 473-485 13 p.

Research output: Research - peer-reviewArticle

Colorectal Neoplasms
Neoplasms
Genes
Encyclopedias
Genome
39 Citations

Multilayer mediated forward and patterned siRNA transfection using linear-PEI at extended N/P ratios

Mehrotra, S., Lee, I. & Chan, C. Jun 2009 In : Acta Biomaterialia. 5, 5, p. 1474-1488 15 p.

Research output: Research - peer-reviewArticle

Polyetherimides
Small Interfering RNA
Multilayers
RNA
Transfection
14 Citations

Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization

Yang, X., Zhou, Y., Jin, R. & Chan, C. 2009 In : Bioinformatics. 25, 17, p. 2236-2243 8 p.

Research output: Research - peer-reviewArticle

Gene Networks
Matrix Factorization
Phenotype
Gene
Knowledge
25 Citations

Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2

Yang, X. & Chan, C. Apr 2009 In : Cell Research. 19, 4, p. 469-486 18 p.

Research output: Research - peer-reviewArticle

Palmitates
Hep G2 Cells
Phosphorylation
Apoptosis
Proteins
25 Citations

The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes

Leekumjorn, S., Cho, H. J., Wu, Y., Wright, N. T., Sum, A. K. & Chan, C. Jul 2009 In : Biochimica et Biophysica Acta - Biomembranes. 1788, 7, p. 1508-1516 9 p.

Research output: Research - peer-reviewArticle

Unsaturated Fatty Acids
Fatty Acids
Membranes
Oleic Acid
Liposomes
2008
4 Citations

A bayesian framework for knowledge driven regression model in micro-array data analysis

Jin, R., Si, L. & Chan, C. 2008 In : International Journal of Data Mining and Bioinformatics. 2, 3, p. 250-267 18 p.

Research output: Research - peer-reviewArticle

Linear regression
data analysis
regression
Linear Models
Gene expression
10 Citations

A novel method incorporating gene ontology information for unsupervised clustering and feature selection

Srivastava, S., Zhang, L., Jin, R. & Chan, C. Dec 4 2008 In : PLoS One. 3, 12, e3860

Research output: Research - peer-reviewArticle

Gene Ontology
Cluster Analysis
Genes
Ontology
Feature extraction
28 Citations

Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line

Srivastava, S. & Chan, C. Feb 1 2008 In : Biotechnology and Bioengineering. 99, 2, p. 399-410 12 p.

Research output: Research - peer-reviewArticle

Metabolic Flux Analysis
Nonesterified Fatty Acids
Hepatocellular Carcinoma
Fatty Acids
Cell Line
14 Citations

Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease

Patil, S., Balu, D., Melrose, J. & Chan, C. 2008 In : BMC Research Notes. 1, 20

Research output: Research - peer-reviewArticle

Palmitic Acid
Alzheimer Disease
Brain
Astrocytes
Cerebellum

Differential regulation of p21 and p27 in cAMP induced differentiation and apoptosis in mesenchymal stem cells

Zhang, L., Seitz, L. & Chan, C. 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: ResearchConference contribution

25 Citations

Experimental and computational studies investigating trehalose protection of HepG2 cells from palmitate-induced toxicity

Leekumjorn, S., Wu, Y., Sum, A. K. & Chan, C. Apr 2008 In : Biophysical Journal. 94, 7, p. 2869-2883 15 p.

Research output: Research - peer-reviewArticle

Trehalose
Palmitates
Hep G2 Cells
Hepatocytes
Cell Membrane
59 Citations

Gene module level analysis: identification to networks and dynamics

Wang, X., Dalkic, E., Wu, M. & Chan, C. Oct 2008 In : Current Opinion in Biotechnology. 19, 5, p. 482-491 10 p.

Research output: Research - peer-reviewArticle

Gene Regulatory Networks
Genes
Biological systems
Molecular Medicine
Inborn Genetic Diseases

Influence of nanoparticle composition on siRNA binding: Effect on cellular delivery for RNA interference

Gredell, J. A., Vogel, E. B., Chan, C., Baker, G. L. & Walton, S. P. 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: ResearchConference contribution

PKR is involved in mediating insulin signaling and inducing insulin resistance

Yang, X. & Chan, C. 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: ResearchConference contribution

35 Citations
Oxidative stress
Polyelectrolytes
Neurons
Astrocytes
neurons
26 Citations

Short time-series microarray analysis: Methods and challenges

Wang, X., Wu, M., Li, Z. & Chan, C. Jul 7 2008 In : BMC Systems Biology. 2, 58

Research output: Research - peer-reviewArticle

Microarray Analysis
Time Series Analysis
Time Series Data
Microarrays
Time series

Systems biology: From identifying toxicity pathways to therapeutic engineering

Li, Z., Chan, C. & Collins, J. J. 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: ResearchConference contribution

15 Citations
glycols
ethylene
templates
acids
Polyelectrolytes
10 Citations

Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity

Li, Z., Srivastava, S., Findlan, R. & Chan, C. Jan 2008 In : Biotechnology Progress. 24, 1, p. 29-37 9 p.

Research output: Research - peer-reviewArticle

free fatty acids
cytotoxicity
gene regulatory networks
Gene Regulatory Networks
Nonesterified Fatty Acids

Using knowledge driven matrix factorization to reconstruct modular gene regulatory network

Zhou, Y., Li, Z., Yang, X., Zhang, L., Srivastava, S., Jin, R. & Chan, C. 2008 Proceedings of the National Conference on Artificial Intelligence. Vol. 2, p. 811-816 6 p.

Research output: ResearchConference contribution

Factorization
Genes
Ontology
Gene expression
Topology
2007
18 Citations

A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells

Li, Z., Srivastava, S., Yang, X., Mittal, S., Norton, P., Resau, J., Haab, B. & Chan, C. May 11 2007 In : BMC Systems Biology. 1, 21

Research output: Research - peer-reviewArticle

Cytotoxicity
Gene Expression Profile
Fatty Acids
Pathway
Cell
18 Citations

A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways

Li, Z., Srivastava, S., Mittal, S., Yang, X., Sheng, L. & Chan, C. Jun 14 2007 In : BMC Bioinformatics. 8, 202

Research output: Research - peer-reviewArticle

Toxicity
Pathway
Gene
Framework
Metabolites
54 Citations

Cell adhesion on polyelectrolyte multilayer coated polydimethylsiloxane surfaces with varying topographies

Kidambi, S., Udpa, N., Schroeder, S. A., Findlan, R., Lee, I. & Chan, C. Aug 2007 In : Tissue Engineering. 13, 8, p. 2105-2117 13 p.

Research output: Research - peer-reviewArticle

Cell adhesion
Polydimethylsiloxane
Polyelectrolytes
Topography
Multilayers
51 Citations
Palmitates
Hydroxyl Radical
Hydrogen Peroxide
Hepatocellular Carcinoma
Permeability
9 Citations

Identification of genes that regulate multiple cellular processes/ responses in the context of lipotoxicity to hepatoma cells

Srivastava, S., Li, Z., Yang, X., Yedwabnick, M., Shaw, S. & Chan, C. Oct 9 2007 In : BMC Genomics. 8, 364

Research output: Research - peer-reviewArticle

Hepatocellular Carcinoma
Genes
Nonesterified Fatty Acids
Triglycerides
Tumor Necrosis Factor-alpha
61 Citations

Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons

Patil, S., Melrose, J. & Chan, C. Oct 2007 In : European Journal of Neuroscience. 26, 8, p. 2131-2141 11 p.

Research output: Research - peer-reviewArticle

Palmitic Acid
Ceramides
Alzheimer Disease
Neurons
Nonesterified Fatty Acids
53 Citations

Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates

Kidambi, S., Sheng, L., Yarmush, M. L., Toner, M., Lee, I. & Chan, C. Mar 8 2007 In : Macromolecular Bioscience. 7, 3, p. 344-353 10 p.

Research output: Research - peer-reviewArticle

Polystyrenes
Coculture Techniques
Hepatocytes
Fibroblasts
Polyelectrolytes
2006
3 Citations

A knowledge driven regression model for gene expression and microarray analysis

Jin, R., Si, L., Srivastava, S., Li, Z. & Chan, C. 2006 Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. p. 5326-5329 4 p. 4029317

Research output: ResearchConference contribution

Microarrays
Gene expression
Genes
Linear regression
Ontology
Microarray Analysis
Linear Models
Gene Expression
Microarrays
Gene expression
1 Citations

Biological network analyses: Computational genomics and systems approaches

Walton, S. P., Li, Z. & Chan, C. Jan 1 2006 In : Molecular Simulation. 32, 3-4, p. 203-209 7 p.

Research output: Research - peer-reviewArticle

Biological Networks
Genomics
Throughput
Chemical engineering
Engineers
4 Citations

Cellular to tissue informatics: Approaches to optimizing cellular function of engineered tissue

Patil, S., Li, Z. & Chan, C. Jul 15 2006 In : Advances in Biochemical Engineering/Biotechnology. 102, p. 139-159 21 p.

Research output: Research - peer-reviewArticle

Tissue
Informatics
Tissue engineering
Tissue Engineering
Artificial Skin