Publications 1992 2018

  • 30 h-Index
  • 110 Article
  • 22 Conference contribution
  • 5 Chapter
  • 1 Review article
2012
16 Citations

Time controlled release of arabinofuranosylcytosine (Ara-C) from agarose hydrogels using layer-by-layer assembly: An in vitro study

Mehrotra, S., Lynam, D., Liu, C., Shahriari, D., Lee, I., Tuszynski, M., Sakamoto, J. & Chan, C. 2012 In : Journal of Biomaterials Science, Polymer Edition. 23, 1-4, p. 439-463 25 p.

Research output: Contribution to journalArticle

Hydrogels
Cytarabine
Sepharose
Cells
Fibroblasts
2011
24 Citations

CAMP initiates early phase neuron-like morphology changes and late phase neural differentiation in mesenchymal stem cells

Zhang, L., Seitz, L. C., Abramczyk, A. M., Liu, L. & Chan, C. Mar 2011 In : Cellular and Molecular Life Sciences. 68, 5, p. 863-876 14 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Neurons
Potassium Chloride
Second Messenger Systems
Cyclic AMP-Dependent Protein Kinases
15 Citations

Identification of novel targets for breast cancer by exploring gene switches on a genome scale

Wu, M., Liu, L. & Chan, C. Nov 3 2011 In : BMC Genomics. 12, 547

Research output: Contribution to journalArticle

Neoplasm Genes
Switch Genes
Genome
Breast Neoplasms
Transducers
128 Citations

Micro RNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β novel targets in sporadic Alzheimer's disease

Geekiyanage, H. & Chan, C. Oct 12 2011 In : Journal of Neuroscience. 31, 41, p. 14820-14830 11 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
MicroRNAs
Amyloid
Alzheimer Disease
Ceramides

Model based surface design to incorporate the effect of soluble cues

Chan, C. & Baek, S. 2011 ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B ed. p. 1195-1196 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations

Molecular mechanism by which palmitate inhibits PKR autophosphorylation

Cho, H., Mukherjee, S., Palasuberniam, P., Pillow, L., Bilgin, B., Nezich, C., Walton, S. P., Feig, M. & Chan, C. Feb 15 2011 In : Biochemistry. 50, 6, p. 1110-1119 10 p.

Research output: Contribution to journalArticle

Palmitates
Phosphotransferases
Adenosine Triphosphate
Binding Sites
eIF-2 Kinase
6 Citations

Polyelectrolyte multilayer stamping in aqueous phase and non-contact mode

Mehrotra, S., Lee, I., Liu, C. & Chan, C. Aug 3 2011 In : Industrial and Engineering Chemistry Research. 50, 15, p. 8851-8858 8 p.

Research output: Contribution to journalArticle

Stamping
Polyelectrolytes
Multilayers
Scaffolds
Substrates
4 Citations

Synergy analysis reveals association between insulin signaling and desmoplakin expression in palmitate treated HepG2 cells

Wang, X., Nath, A., Yang, X., Portis, A., Walton, S. P. & Chan, C. Nov 23 2011 In : PLoS One. 6, 11, e28138

Research output: Contribution to journalArticle

Desmoplakins
Palmitates
palmitates
Hep G2 Cells
insulin
2010
8 Citations

Cancer-drug associations: A complex system

Dalkic, E., Wang, X., Wright, N. & Chan, C. 2010 In : PLoS One. 5, 4, e10031

Research output: Contribution to journalArticle

Large scale systems
drugs
neoplasms
Pharmaceutical Preparations
Neoplasms
37 Citations

Cell adhesive behavior on thin polyelectrolyte multilayers: Cells attempt to achieve homeostasis of its adhesion energy

Mehrotra, S., Hunley, S. C., Pawelec, K. M., Zhang, L., Lee, I., Baek, S. & Chan, C. Aug 3 2010 In : Langmuir. 26, 15, p. 12794-12802 9 p.

Research output: Contribution to journalArticle

homeostasis
Polyelectrolytes
Adhesives
adhesives
Multilayers
14 Citations

Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles

Portis, A. M., Carballo, G., Baker, G. L., Chan, C. & Walton, S. P. Sep 2010 In : Microscopy Research and Technique. 73, 9, p. 878-885 8 p.

Research output: Contribution to journalArticle

Confocal microscopy
RNA
Confocal Microscopy
Nanoparticles
Small Interfering RNA
46 Citations

Designing highly active siRNAs for therapeutic applications

Patrick Walton, S., Wu, M., Gredell, J. A. & Chan, C. Dec 2010 In : FEBS Journal. 277, 23, p. 4806-4813 8 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Therapeutics
RNA Interference
RNA
Thermodynamics
2 Citations

Erratum: Time controlled protein release from layer-by-layer assembled multilayer functionalized agarose hydrogels (Advanced Functional Materials (2010) 20 (247) 10.1002/adfm.200901172)

Mehrotra, S., Lynam, D., Maloney, R., Pawelec, K. M., Tuszynski, M. H., Lee, I., Chan, C. & Sakamoto, J. Mar 24 2010 In : Advanced Functional Materials. 20, 6, p. 878 1 p.

Research output: Contribution to journalArticle

Functional materials
Hydrogels
Multilayers
proteins
Proteins
45 Citations
Cell Separation
Stem cells
Mesenchymal Stromal Cells
Rats
Hematopoietic Stem Cells
11 Citations
Cell Separation
Stem cells
Mesenchymal Stromal Cells
Rats
Hematopoietic Stem Cells
35 Citations

Recognition of siRNA asymmetry by TAR RNA binding protein

Gredell, J. A., Dittmer, M. J., Wu, M., Chan, C. & Walton, S. P. Apr 13 2010 In : Biochemistry. 49, 14, p. 3148-3155 8 p.

Research output: Contribution to journalArticle

Small Interfering RNA
RNA-Induced Silencing Complex
RNA Interference
RNA
Reduced instruction set computing
25 Citations

Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells

Zhang, L., Seitz, L. C., Abramczyk, A. M. & Chan, C. Mar 10 2010 In : Experimental Cell Research. 316, 5, p. 716-727 12 p.

Research output: Contribution to journalArticle

Palmitates
Hep G2 Cells
Organelle Biogenesis
Cell Death
Reactive Oxygen Species
25 Citations

The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells

Yang, X., Nath, A., Opperman, M. J. & Chan, C. Oct 1 2010 In : Molecular Biology of the Cell. 21, 19, p. 3449-3458 10 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
Insulin Receptor Substrate Proteins
Double-Stranded RNA
Hep G2 Cells
Phosphorylation
68 Citations

Time controlled protein release from layer-by-layer assembled multilayer functionalized agarose hydrogels

Mehrotra, S., Lynam, D., Maloney, R., Pawelec, K. M., Tuszynski, M. H., Lee, I., Chan, C. & Sakamoto, J. Jan 22 2010 In : Advanced Functional Materials. 20, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

Hydrogels
Sepharose
Multilayers
proteins
Proteins
36 Citations

Withanolide a and asiatic acid modulate multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearance

Patil, S. P., Maki, S., Khedkar, S. A., Rigby, A. C. & Chan, C. Jul 23 2010 In : Journal of Natural Products. 73, 7, p. 1196-1202 7 p.

Research output: Contribution to journalArticle

Withanolides
Amyloid beta-Protein Precursor
Amyloid beta-Peptides
Alzheimer Disease
Processing
2009
22 Citations

A dynamic analysis of IRS-PKR signaling in liver cells: A discrete modeling approach

Wu, M., Yang, X. & Chan, C. 2009 In : PLoS One. 4, 12, e8040

Research output: Contribution to journalArticle

Liver
Dynamic analysis
hepatocytes
Insulin
insulin

Integrative analysis of cancer pathway progression and coherence

Dalkic, E., Walter Nash, D. E., Fassia, M. K. & Chan, C. 2009 In : Proteomics - Clinical Applications. 3, 4, p. 473-485 13 p.

Research output: Contribution to journalArticle

Encyclopedias
Colorectal Neoplasms
Genes
Genome
Carcinoma
40 Citations

Multilayer mediated forward and patterned siRNA transfection using linear-PEI at extended N/P ratios

Mehrotra, S., Lee, I. & Chan, C. Jun 2009 In : Acta Biomaterialia. 5, 5, p. 1474-1488 15 p.

Research output: Contribution to journalArticle

Polyetherimides
RNA
Small Interfering RNA
Transfection
Multilayers
15 Citations

Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization

Yang, X., Zhou, Y., Jin, R. & Chan, C. 2009 In : Bioinformatics. 25, 17, p. 2236-2243 8 p.

Research output: Contribution to journalArticle

Gene Networks
Matrix Factorization
Gene Regulatory Networks
Factorization
Phenotype
25 Citations

Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2

Yang, X. & Chan, C. Apr 2009 In : Cell Research. 19, 4, p. 469-486 18 p.

Research output: Contribution to journalArticle

Palmitates
Hep G2 Cells
Phosphorylation
Apoptosis
eIF-2 Kinase
31 Citations

The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes

Leekumjorn, S., Cho, H. J., Wu, Y., Wright, N. T., Sum, A. K. & Chan, C. Jul 2009 In : Biochimica et Biophysica Acta - Biomembranes. 1788, 7, p. 1508-1516 9 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Fatty Acids
Oleic Acid
Membranes
Liposomes
2008
4 Citations

A bayesian framework for knowledge driven regression model in micro-array data analysis

Jin, R., Si, L. & Chan, C. 2008 In : International Journal of Data Mining and Bioinformatics. 2, 3, p. 250-267 18 p.

Research output: Contribution to journalArticle

Linear regression
Linear Models
data analysis
regression
Gene expression
10 Citations

A novel method incorporating gene ontology information for unsupervised clustering and feature selection

Srivastava, S., Zhang, L., Jin, R. & Chan, C. Dec 4 2008 In : PLoS One. 3, 12, e3860

Research output: Contribution to journalArticle

Gene Ontology
Cluster Analysis
Ontology
Feature extraction
Genes
30 Citations

Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line

Srivastava, S. & Chan, C. Feb 1 2008 In : Biotechnology and Bioengineering. 99, 2, p. 399-410 12 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Fatty acids
Nonesterified Fatty Acids
Toxicity
Hepatocellular Carcinoma
15 Citations

Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease

Patil, S., Balu, D., Melrose, J. & Chan, C. 2008 In : BMC Research Notes. 1, 20

Research output: Contribution to journalArticle

Palmitic Acid
Brain
Alzheimer Disease
Astrocytes
Cerebellum

Differential regulation of p21 and p27 in cAMP induced differentiation and apoptosis in mesenchymal stem cells

Zhang, L., Seitz, L. & Chan, C. 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cell death
Stem cells
26 Citations

Experimental and computational studies investigating trehalose protection of HepG2 cells from palmitate-induced toxicity

Leekumjorn, S., Wu, Y., Sum, A. K. & Chan, C. Apr 2008 In : Biophysical Journal. 94, 7, p. 2869-2883 15 p.

Research output: Contribution to journalArticle

Trehalose
Palmitates
Hep G2 Cells
Hepatocytes
Cell Membrane
60 Citations

Gene module level analysis: identification to networks and dynamics

Wang, X., Dalkic, E., Wu, M. & Chan, C. Oct 2008 In : Current Opinion in Biotechnology. 19, 5, p. 482-491 10 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Biological systems
Genes
Molecular Medicine
Inborn Genetic Diseases

Influence of nanoparticle composition on siRNA binding: Effect on cellular delivery for RNA interference

Gredell, J. A., Vogel, E. B., Chan, C., Baker, G. L. & Walton, S. P. 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Thermionic emission
RNA
Nanoparticles
Chemical analysis

PKR is involved in mediating insulin signaling and inducing insulin resistance

Yang, X. & Chan, C. 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Insulin
36 Citations
Oxidative stress
Polyelectrolytes
Styrene
neurons
Neurons
28 Citations

Short time-series microarray analysis: Methods and challenges

Wang, X., Wu, M., Li, Z. & Chan, C. Jul 7 2008 In : BMC Systems Biology. 2, 58

Research output: Contribution to journalArticle

Microarray Analysis
Time Series Analysis
Microarrays
Time Series Data
Time series

Systems biology: From identifying toxicity pathways to therapeutic engineering

Li, Z., Chan, C. & Collins, J. J. 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Toxicity
Systems Biology
16 Citations
Polyelectrolytes
Polyethylene glycols
glycols
Multilayers
ethylene
10 Citations

Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity

Li, Z., Srivastava, S., Findlan, R. & Chan, C. Jan 2008 In : Biotechnology Progress. 24, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Nonesterified Fatty Acids
Palmitates
palmitates
free fatty acids

Using knowledge driven matrix factorization to reconstruct modular gene regulatory network

Zhou, Y., Li, Z., Yang, X., Zhang, L., Srivastava, S., Jin, R. & Chan, C. 2008 Proceedings of the National Conference on Artificial Intelligence. Vol. 2, p. 811-816 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Factorization
Genes
Ontology
Gene expression
Topology
2007
18 Citations

A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells

Li, Z., Srivastava, S., Yang, X., Mittal, S., Norton, P., Resau, J., Haab, B. & Chan, C. May 11 2007 In : BMC Systems Biology. 1, 21

Research output: Contribution to journalArticle

Cytotoxicity
Gene Expression Profile
Tumor Necrosis Factor
Hep G2 Cells
Fatty Acids
18 Citations

A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways

Li, Z., Srivastava, S., Mittal, S., Yang, X., Sheng, L. & Chan, C. Jun 14 2007 In : BMC Bioinformatics. 8, 202

Research output: Contribution to journalArticle

Toxicity
Metabolites
Gene expression
Pathway
Genes
56 Citations

Cell adhesion on polyelectrolyte multilayer coated polydimethylsiloxane surfaces with varying topographies

Kidambi, S., Udpa, N., Schroeder, S. A., Findlan, R., Lee, I. & Chan, C. Aug 2007 In : Tissue Engineering. 13, 8, p. 2105-2117 13 p.

Research output: Contribution to journalArticle

Cell adhesion
Polydimethylsiloxane
Polyelectrolytes
Cell Adhesion
Topography
52 Citations
Palmitates
Cytotoxicity
Hydroxyl Radical
Hydrogen Peroxide
Hepatocellular Carcinoma
9 Citations

Identification of genes that regulate multiple cellular processes/ responses in the context of lipotoxicity to hepatoma cells

Srivastava, S., Li, Z., Yang, X., Yedwabnick, M., Shaw, S. & Chan, C. Oct 9 2007 In : BMC Genomics. 8, 364

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Nonesterified Fatty Acids
Triglycerides
NADH Dehydrogenase
Genes
67 Citations

Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons

Patil, S., Melrose, J. & Chan, C. Oct 2007 In : European Journal of Neuroscience. 26, 8, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

Palmitic Acid
Ceramides
Alzheimer Disease
Neurons
Nonesterified Fatty Acids
57 Citations

Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates

Kidambi, S., Sheng, L., Yarmush, M. L., Toner, M., Lee, I. & Chan, C. Mar 8 2007 In : Macromolecular Bioscience. 7, 3, p. 344-353 10 p.

Research output: Contribution to journalArticle

Polystyrenes
Fibroblasts
Coculture Techniques
Polyelectrolytes
Cell culture
2006
3 Citations

A knowledge driven regression model for gene expression and microarray analysis

Jin, R., Si, L., Srivastava, S., Li, Z. & Chan, C. 2006 Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. p. 5326-5329 4 p. 4029317

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Microarrays
Gene expression
Genes
Linear regression
Ontology
1 Citations

Biological network analyses: Computational genomics and systems approaches

Walton, S. P., Li, Z. & Chan, C. Jan 1 2006 In : Molecular Simulation. 32, 3-4, p. 203-209 7 p.

Research output: Contribution to journalArticle

Biological Networks
Genomics
Throughput
chemical engineering
Chemical engineering