Publications 1992 2016

  • 29 h-Index
  • 110 Article
  • 22 Conference contribution
  • 5 Chapter
2006
58 Citations

Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons

Patil, S., Sheng, L., Masserang, A. & Chan, C. Oct 2 2006 In : Neuroscience Letters. 406, 1-2, p. 55-59 5 p.

Research output: Research - peer-reviewArticle

Palmitic Acid
Amyloid beta-Protein Precursor
Astrocytes
Alzheimer Disease
Up-Regulation

Studying the mechanism of transcriptional regulation of stem cell proliferation and differentiation

Zhang, L., Howes, T., Wright, N. & Chan, C. 2006 AIChE Annual Meeting, Conference Proceedings.

Research output: ResearchConference contribution

Cyclin D1
Cell proliferation
Stem cells
Transcription
Cells
34 Citations

Using a state-space model with hidden variables to infer transcription factor activities

Li, Z., Shaw, S. M., Yedwabnick, M. J. & Chan, C. Mar 15 2006 In : Bioinformatics. 22, 6, p. 747-754 8 p.

Research output: Research - peer-reviewArticle

Hidden Variables
State-space Model
Transcription Factor
Space Simulation
Transcription Factors
2005
Metabolome
Transcriptome
1 Citations

Inferring pathways that confer a cellular phenotype by integrating gene expression and metabolic profiles

Li, Z., Srivastava, S., Yang, X. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 10382 1 p.

Research output: ResearchConference contribution

Metabolites
Gene expression
Genes
Discriminant analysis
Cytotoxicity

Inferring transcription factor activities with a probabilistic framework of Hidden Markov Model

Li, Z., Shaw, S. M., Yedwabnick, M. J. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 11699 1 p.

Research output: ResearchConference contribution

Transcription factors
Hidden Markov models
Genes
Gene expression
Proteins

Integrating gene expression and metabolic profiles to infer pathays and networks that confer palmitate induced cytotoxicity in hepg2 cells

Li, Z., Srivastava, S. & Chan, C. 2005 Proceedings of the 2005 Summer Bioengineering Conference. Vol. 2005, p. 133-134 2 p.

Research output: ResearchConference contribution

Cytotoxicity
Gene expression

Involvement of saturated fatty acids in the pathogenesis of Alzheimer's disease

Patil, S. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 8964 1 p.

Research output: ResearchConference contribution

Saturated fatty acids
Neurons
Astrocytes
Nutrition
Oils and fats

Knowledge-based integration of metabolic and genetic information to identify targets of fatty acid toxicity

Srivastava, S. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 8606 1 p.

Research output: ResearchConference contribution

Fatty acids
Toxicity
Genes
Fluxes
Proteins
63 Citations

Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons

Patil, S. & Chan, C. Aug 26 2005 In : Neuroscience Letters. 384, 3, p. 288-293 6 p.

Research output: Research - peer-reviewArticle

Stearic Acids
Nonesterified Fatty Acids
Alzheimer Disease
Neurons
Fatty Acids

Patterns of aptamers on polyelectrolyte multilayers

Kidambi, S., Lee, I. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 4296 1 p.

Research output: ResearchConference contribution

Polyelectrolytes
Multilayers
Multilayer films
Nucleic acids
Proteins

PH and salt responsive peg sams on polyelectrolyte multilayer

Kidambi, S., Chan, C. & Lee, I. 2005 AIChE Annual Meeting, Conference Proceedings. p. 4685 1 p.

Research output: ResearchConference contribution

Polyelectrolytes
Multilayers
Electrolytes
Salts
Multilayer films

Regulation of apoptosis by free fatty acids and Tnf-α: Role of double-stranded RNA-dependent protein kinase (Pkr)

Yang, X., Li, Z., Srivastava, S. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 8915-8916 2 p.

Research output: ResearchConference contribution

Cell death
RNA
Fatty acids
Proteins
Tumor Necrosis Factor-alpha
2004
61 Citations

Controlling primary hepatocyte adhesion and spreading on protein-free polyelectrolyte multilayer films

Kidambi, S., Lee, I. & Chan, C. Dec 22 2004 In : Journal of the American Chemical Society. 126, 50, p. 16286-16287 2 p.

Research output: Research - peer-reviewArticle

Multilayer films
Polyelectrolytes
Adhesion
Proteins
Hepatocytes
7 Citations

Extracting novel information from gene expression data

Li, Z. & Chan, C. Aug 1 2004 In : Trends in Biotechnology. 22, 8, p. 381-383 3 p.

Research output: Research - peer-reviewArticle

Gene expression
Gene Expression
Transcription Factors
Transcription factors
Network components
93 Citations

Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies

Chan, C., Berthiaume, F., Nath, B. D., Tilles, A. W., Toner, M. & Yarmush, M. L. Nov 2004 In : Liver Transplantation. 10, 11, p. 1331-1342 12 p.

Research output: Research - peer-reviewArticle

Tissue Engineering
Technology
Liver
Equipment and Supplies
Artificial Liver
33 Citations
Testing
Metabolic Networks and Pathways
Tricarboxylic Acids
Signal transduction
Reverse engineering
7 Citations

Insulin concentration during preconditioning mediates the regulation of urea synthesis during exposure to amino acid-supplemented plasma

Li, Z., Yarmush, M. L. & Chan, C. Nov 2004 In : Tissue Engineering. 10, 11-12, p. 1737-1746 10 p.

Research output: Research - peer-reviewArticle

Insulin
Urea
Amino acids
Plasmas
Amino Acids
21 Citations

Integrating gene expression and metabolic profiles

Li, Z. & Chan, C. Jun 25 2004 In : Journal of Biological Chemistry. 279, 26, p. 27124-27137 14 p.

Research output: Research - peer-reviewArticle

Metabolome
Transcriptome
Genes
Gene expression
Metabolic Networks and Pathways
17 Citations

Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function

Hwang, D., Stephanopoulos, G. & Chan, C. Mar 1 2004 In : Bioinformatics. 20, 4, p. 487-499 13 p.

Research output: Research - peer-reviewArticle

Inverse Modeling
Multiblock
Environmental Factors
Least-Squares Analysis
Tissue
45 Citations
Self assembled monolayers
Polyelectrolytes
Polyethylene glycols
Multilayers
Acids
1 Citations

Selective primary hepatocyte adhesion on polyelectrolyte multilayer: Template for patterned cell co-culture

Kidambi, S., Lee, I. & Chan, C. 2004 AIChE Annual Meeting, Conference Proceedings. p. 8351-8355 5 p. 76f

Research output: ResearchConference contribution

Polyelectrolytes
Styrene
Multilayers
Adhesion
Hepatocytes
2003
38 Citations

Application of multivariate analysis to optimize function of cultured hepatocytes

Chan, C., Hwang, D., Stephanopoulos, G. N., Yarmush, M. L. & Stephanopoulos, G. Mar 2003 In : Biotechnology Progress. 19, 2, p. 580-598 19 p.

Research output: Research - peer-reviewArticle

hepatocytes
multivariate analysis
Hepatocytes
Multivariate Analysis
Liver
65 Citations

Metabolic Flux Analysis of Cultured Hepatocytes Exposed to Plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L. Jan 5 2003 In : Biotechnology and Bioengineering. 81, 1, p. 33-49 17 p.

Research output: Research - peer-reviewArticle

Fluxes
Plasmas
Hepatocytes
Metabolic Flux Analysis
Insulin
44 Citations

Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L. Jan 2003 In : Metabolic Engineering. 5, 1, p. 1-15 15 p.

Research output: Research - peer-reviewArticle

Hormones
Fluxes
Plasmas
Amino Acids
Hepatocytes
2002

Application of multivariate analysis for optimizing & predicting hepatic function

Chan, C., Hwang, D., Stephanopoulous, G., Stephanopoulous, G. N. & Yarmush, M. L. 2002 Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1, p. 724-725 2 p.

Research output: ResearchConference contribution

Multivariate Analysis
Fluxes
Urea
Triglycerides
Discriminant analysis
Insulin
Biotechnology
Lipids
Cells
Plasmas
27 Citations

Metabolic pre-conditioning of cultured cells in physiological levels of insulin: Generating resistance to the lipid-accumulating effects of plasma in hepatocytes

Chan, C., Berthiaume, F., Washizu, J., Toner, M. & Yarmush, M. L. Jun 30 2002 In : Biotechnology and Bioengineering. 78, 7, p. 753-760 8 p.

Research output: Research - peer-reviewArticle

Cells
Insulin
Lipids
Plasmas
Hepatocytes
2001

Application of metabolic engineering to cellular processes of the liver: Bioartificial liver development

Chan, C., Washizu, J., Berthiaume, F., Toner, M. & Yarmush, M. L. 2001 American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Kamm, R. D., Schmid-Schoenbein, G. W., Atesian, G. A. & Hefzy, M. S. (eds.). Vol. 50, p. 357-358 2 p.

Research output: ResearchConference contribution

Metabolic engineering
Liver
Fluxes
Insulin
Collagen
2000
28 Citations

Amino acid supplementation improves cell-specific functions of the rat hepatocytes exposed to human plasma

Washizu, J., Chan, C., Berthiaume, F., Tompkins, R. G., Toner, M. & Yarmush, M. L. 2000 In : Tissue Engineering. 6, 5, p. 497-504 8 p.

Research output: Research - peer-reviewArticle

Plasma (human)
Amino acids
Rats
Hepatocytes
Amino Acids
27 Citations

Optimization of rat hepatocyte culture in citrated human plasma

Washizu, J., Berthiaume, F., Chan, C., Tompkins, R. G., Toner, M. & Yarmush, M. L. 2000 In : Journal of Surgical Research. 93, 2, p. 237-246 10 p.

Research output: Research - peer-reviewArticle

Hepatocytes
Culture Media
Artificial Liver
Urea
Albumins
1998
20 Citations

Essentially exact characteristics of turbulent convection in a round tube

Heng, L., Chan, C. & Churchill, S. W. Dec 18 1998 In : Chemical Engineering Journal. 71, 3, p. 163-173 11 p.

Research output: Research - peer-reviewArticle

Prandtl number
Convection
convection
Nusselt number
Turbulent flow
1996
5 Citations

Combustion of ethane with small concentrations of methyl chloride in a refractory tube burner

Brown, M. A., Chan, C., Targett, M. J., Holtzmuller, M. & Churchill, S. W. 1996 In : Combustion Science and Technology. 115, 4-6, p. 207-227 21 p.

Research output: Research - peer-reviewArticle

methyl chloride
burners
refractories
ethane
tubes
1995
26 Citations
Turbulent flow
Shear stress
turbulent flow
shear stress
Viscosity
29 Citations

Turbulent flow in channels in terms of local turbulent shear and normal stresses

Churchill, S. W. & Chan, C. Dec 1995 In : AICHE Journal. 41, 12, p. 2513-2521 9 p.

Research output: Research - peer-reviewArticle

Friction
Viscosity
Pressure
Turbulent flow
Shear stress
1994
15 Citations
turbulent flow
friction
Turbulent flow
Friction
distribution
1992
3 Citations

Thermally stabilized combustion as a means of studying the devolatilization of coal

Chan, C., Arai, N., Lior, N. & Churchill, S. W. Mar 1992 In : Industrial and Engineering Chemistry Research. 31, 3, p. 681-687 7 p.

Research output: Research - peer-reviewArticle

combustion
coal
temperature
particle
Coal