Publications 1992 2016

  • 29 h-Index
  • 110 Article
  • 22 Conference contribution
  • 5 Chapter
2006
57 Citations

Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons

Patil, S., Sheng, L., Masserang, A. & Chan, C. Oct 2 2006 In : Neuroscience Letters. 406, 1-2, p. 55-59 5 p.

Research output: Contribution to journalArticle

Palmitic Acid
Amyloid beta-Protein Precursor
Astrocytes
Alzheimer Disease
Up-Regulation

Studying the mechanism of transcriptional regulation of stem cell proliferation and differentiation

Zhang, L., Howes, T., Wright, N. & Chan, C. 2006 AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Stem cells
Status Epilepticus
Transcription
Cells
Proteins
32 Citations

Using a state-space model with hidden variables to infer transcription factor activities

Li, Z., Shaw, S. M., Yedwabnick, M. J. & Chan, C. Mar 15 2006 In : Bioinformatics. 22, 6, p. 747-754 8 p.

Research output: Contribution to journalArticle

State-space model
Space Simulation
Transcription Factors
Anthralin
Transcription factor
1 Citations

Inferring pathways that confer a cellular phenotype by integrating gene expression and metabolic profiles

Li, Z., Srivastava, S., Yang, X. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 10382 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gene expression
Metabolites
Genes
Discriminant analysis
Cytotoxicity

Inferring transcription factor activities with a probabilistic framework of Hidden Markov Model

Li, Z., Shaw, S. M., Yedwabnick, M. J. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 11699 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Transcription factors
Hidden Markov models
Genes
Gene expression
Proteins

Integrating gene expression and metabolic profiles to infer pathays and networks that confer palmitate induced cytotoxicity in hepg2 cells

Li, Z., Srivastava, S. & Chan, C. 2005 Proceedings of the 2005 Summer Bioengineering Conference. Vol. 2005, p. 133-134 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cytotoxicity
Gene expression

Involvement of saturated fatty acids in the pathogenesis of Alzheimer's disease

Patil, S. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 8964 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Neurons
Saturated fatty acids
Nutrition
Oils and fats
Fatty acids

Knowledge-based integration of metabolic and genetic information to identify targets of fatty acid toxicity

Srivastava, S. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 8606 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fatty acids
Toxicity
Genes
Fluxes
Proteins
61 Citations

Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons

Patil, S. & Chan, C. Aug 26 2005 In : Neuroscience Letters. 384, 3, p. 288-293 6 p.

Research output: Contribution to journalArticle

Stearic Acids
Nonesterified Fatty Acids
Alzheimer Disease
Neurons
Fatty Acids

Patterns of aptamers on polyelectrolyte multilayers

Kidambi, S., Lee, I. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 4296 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Polyelectrolytes
Multilayers
Multilayer films
Nucleic acids
Proteins

PH and salt responsive peg sams on polyelectrolyte multilayer

Kidambi, S., Chan, C. & Lee, I. 2005 AIChE Annual Meeting, Conference Proceedings. p. 4685 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Electrolytes
Multilayers
Salts
Multilayer films
Polyethylene glycols

Regulation of apoptosis by free fatty acids and Tnf-α: Role of double-stranded RNA-dependent protein kinase (Pkr)

Yang, X., Li, Z., Srivastava, S. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 8915-8916 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fatty acids
Cell death
Phosphorylation
Proteins
Transcription factors
2004
60 Citations

Controlling primary hepatocyte adhesion and spreading on protein-free polyelectrolyte multilayer films

Kidambi, S., Lee, I. & Chan, C. Dec 22 2004 In : Journal of the American Chemical Society. 126, 50, p. 16286-16287 2 p.

Research output: Contribution to journalArticle

Styrene
Hepatocytes
Proteins
Edema Disease of Swine
Chlorides
7 Citations

Extracting novel information from gene expression data

Li, Z. & Chan, C. Aug 1 2004 In : Trends in Biotechnology. 22, 8, p. 381-383 3 p.

Research output: Contribution to journalArticle

Gene Expression
Gene expression
Transcription Factors
Transcription factors
Oligonucleotide Array Sequence Analysis
92 Citations

Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies

Chan, C., Berthiaume, F., Nath, B. D., Tilles, A. W., Toner, M. & Yarmush, M. L. Nov 2004 In : Liver Transplantation. 10, 11, p. 1331-1342 12 p.

Research output: Contribution to journalArticle

Tissue Engineering
Technology
Liver
Equipment and Supplies
Artificial Liver
33 Citations
Blood Stains
Anthralin
Metabolic Networks and Pathways
National Bibliographies
Lutheran Blood-Group System
7 Citations

Insulin concentration during preconditioning mediates the regulation of urea synthesis during exposure to amino acid-supplemented plasma

Li, Z., Yarmush, M. L. & Chan, C. Nov 2004 In : Tissue Engineering. 10, 11-12, p. 1737-1746 10 p.

Research output: Contribution to journalArticle

Insulin
Urea
Amino Acids
Amino acids
Plasmas
21 Citations

Integrating gene expression and metabolic profiles

Li, Z. & Chan, C. Jun 25 2004 In : Journal of Biological Chemistry. 279, 26, p. 27124-27137 14 p.

Research output: Contribution to journalArticle

Metabolome
Transcriptome
Genes
Metabolic Networks and Pathways
Least-Squares Analysis
17 Citations

Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function

Hwang, D., Stephanopoulos, G. & Chan, C. Mar 1 2004 In : Bioinformatics. 20, 4, p. 487-499 13 p.

Research output: Contribution to journalArticle

Environmental factors
Anthralin
Least-Squares Analysis
Multiblock
Library Catalogs
45 Citations
Polyelectrolytes
Magnesium Deficiency
Ethylene Glycol
Acids
Polyethylene glycols
1 Citations

Selective primary hepatocyte adhesion on polyelectrolyte multilayer: Template for patterned cell co-culture

Kidambi, S., Lee, I. & Chan, C. 2004 AIChE Annual Meeting, Conference Proceedings. p. 8351-8355 5 p. 76f

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Polyelectrolytes
Multilayers
Styrene
Polymers
Multilayer films
2003
38 Citations

Application of multivariate analysis to optimize function of cultured hepatocytes

Chan, C., Hwang, D., Stephanopoulos, G. N., Yarmush, M. L. & Stephanopoulos, G. Mar 2003 In : Biotechnology Progress. 19, 2, p. 580-598 19 p.

Research output: Contribution to journalArticle

Hepatocytes
Multivariate Analysis
Liver
hepatocytes
liver function
65 Citations

Metabolic Flux Analysis of Cultured Hepatocytes Exposed to Plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L. Jan 5 2003 In : Biotechnology and Bioengineering. 81, 1, p. 33-49 17 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Hepatocytes
Plasmas
Callosities
Insulin
44 Citations

Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L. Jan 2003 In : Metabolic Engineering. 5, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Hepatocytes
Hormones
Amino Acids
Amino acids
2002

Application of multivariate analysis for optimizing & predicting hepatic function

Chan, C., Hwang, D., Stephanopoulous, G., Stephanopoulous, G. N. & Yarmush, M. L. 2002 Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1, p. 724-725 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fluxes
Hereditary Corneal Dystrophies
Anthralin
Urea
Conjunctival Diseases
26 Citations

Metabolic pre-conditioning of cultured cells in physiological levels of insulin: Generating resistance to the lipid-accumulating effects of plasma in hepatocytes

Chan, C., Berthiaume, F., Washizu, J., Toner, M. & Yarmush, M. L. Jun 30 2002 In : Biotechnology and Bioengineering. 78, 7, p. 753-760 8 p.

Research output: Contribution to journalArticle

Insulin Resistance
Hepatocytes
Cultured Cells
Lipids
Plasmas
2001

Application of metabolic engineering to cellular processes of the liver: Bioartificial liver development

Chan, C., Washizu, J., Berthiaume, F., Toner, M. & Yarmush, M. L. 2001 American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Kamm, R. D., Schmid-Schoenbein, G. W., Atesian, G. A. & Hefzy, M. S. (eds.). Vol. 50, p. 357-358 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liver
Fluxes
Metabolic engineering
Insulin
Collagen
2000
28 Citations

Amino acid supplementation improves cell-specific functions of the rat hepatocytes exposed to human plasma

Washizu, J., Chan, C., Berthiaume, F., Tompkins, R. G., Toner, M. & Yarmush, M. L. 2000 In : Tissue Engineering. 6, 5, p. 497-504 8 p.

Research output: Contribution to journalArticle

Hepatocytes
Amino Acids
Plasmas
Hormones
Amino acids
27 Citations

Optimization of rat hepatocyte culture in citrated human plasma

Washizu, J., Berthiaume, F., Chan, C., Tompkins, R. G., Toner, M. & Yarmush, M. L. 2000 In : Journal of Surgical Research. 93, 2, p. 237-246 10 p.

Research output: Contribution to journalArticle

Hepatocytes
Culture Media
Artificial Liver
Urea
Albumins
1998
20 Citations

Essentially exact characteristics of turbulent convection in a round tube

Heng, L., Chan, C. & Churchill, S. W. Dec 18 1998 In : Chemical Engineering Journal. 71, 3, p. 163-173 11 p.

Research output: Contribution to journalArticle

Convection
convection
Premature Rupture Fetal Membranes
Prandtl number
Epirizole
1996
5 Citations

Combustion of ethane with small concentrations of methyl chloride in a refractory tube burner

Brown, M. A., Chan, C., Targett, M. J., Holtzmuller, M. & Churchill, S. W. 1996 In : Combustion Science and Technology. 115, 4-6, p. 207-227 21 p.

Research output: Contribution to journalArticle

temperature
Acetanilides
Temperature
Abandoned Children
methyl chloride
1995
26 Citations
Acetyl-CoA Hydrolase
Protamine Kinase
Shear stress
shear stress
Edema Disease of Swine
29 Citations

Turbulent flow in channels in terms of local turbulent shear and normal stresses

Churchill, S. W. & Chan, C. Dec 1995 In : AICHE Journal. 41, 12, p. 2513-2521 9 p.

Research output: Contribution to journalArticle

Acetyl-CoA Hydrolase
Friction
Viscosity
Addison Disease
Protamine Kinase
1994
15 Citations
Acetyl-CoA Hydrolase
Friction
Lutheran Blood-Group System
Protamine Kinase
Self Concept
1992
3 Citations

Thermally stabilized combustion as a means of studying the devolatilization of coal

Chan, C., Arai, N., Lior, N. & Churchill, S. W. Mar 1992 In : Industrial and Engineering Chemistry Research. 31, 3, p. 681-687 7 p.

Research output: Contribution to journalArticle

Acetyl-CoA Hydrolase
Acetanilides
Abandoned Children
Bacillus megaterium
combustion