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Publications 1992 2018

  • 30 h-Index
  • 110 Article
  • 22 Conference contribution
  • 5 Chapter
  • 1 Review article
2006
4 Citations

Cellular to tissue informatics: Approaches to optimizing cellular function of engineered tissue

Patil, S., Li, Z. & Chan, C. Jul 15 2006 In : Advances in Biochemical Engineering/Biotechnology. 102, p. 139-159 21 p.

Research output: Contribution to journalArticle

Informatics
Tissue
Tissue Engineering
Tissue engineering
Artificial Skin
59 Citations

Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons

Patil, S., Sheng, L., Masserang, A. & Chan, C. Oct 2 2006 In : Neuroscience Letters. 406, 1-2, p. 55-59 5 p.

Research output: Contribution to journalArticle

Palmitic Acid
Amyloid beta-Protein Precursor
Astrocytes
Alzheimer Disease
Up-Regulation

Studying the mechanism of transcriptional regulation of stem cell proliferation and differentiation

Zhang, L., Howes, T., Wright, N. & Chan, C. 2006 AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cyclin D1
Cell proliferation
Transcription
Stem cells
Transcription factors
34 Citations

Using a state-space model with hidden variables to infer transcription factor activities

Li, Z., Shaw, S. M., Yedwabnick, M. J. & Chan, C. Mar 15 2006 In : Bioinformatics. 22, 6, p. 747-754 8 p.

Research output: Contribution to journalArticle

Space Simulation
Hidden Variables
Transcription factors
State-space Model
Transcription Factor
2005
Metabolome
Transcriptome
1 Citations

Inferring pathways that confer a cellular phenotype by integrating gene expression and metabolic profiles

Li, Z., Srivastava, S., Yang, X. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 10382 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Metabolites
Gene expression
Genes
Discriminant analysis
Cytotoxicity

Inferring transcription factor activities with a probabilistic framework of Hidden Markov Model

Li, Z., Shaw, S. M., Yedwabnick, M. J. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 11699 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Transcription factors
Hidden Markov models
Genes
Gene expression
Proteins

Integrating gene expression and metabolic profiles to infer pathays and networks that confer palmitate induced cytotoxicity in hepg2 cells

Li, Z., Srivastava, S. & Chan, C. 2005 Proceedings of the 2005 Summer Bioengineering Conference. Vol. 2005, p. 133-134 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cytotoxicity
Gene expression

Involvement of saturated fatty acids in the pathogenesis of Alzheimer's disease

Patil, S. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 8964 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Saturated fatty acids
Neurons
Nutrition
Oils and fats
Fatty acids

Knowledge-based integration of metabolic and genetic information to identify targets of fatty acid toxicity

Srivastava, S. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 8606 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fatty acids
Toxicity
Genes
Saturated fatty acids
Fluxes
65 Citations

Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons

Patil, S. & Chan, C. Aug 26 2005 In : Neuroscience Letters. 384, 3, p. 288-293 6 p.

Research output: Contribution to journalArticle

Stearic Acids
Nonesterified Fatty Acids
Alzheimer Disease
Neurons
Fatty Acids

Patterns of aptamers on polyelectrolyte multilayers

Kidambi, S., Lee, I. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 4296 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Polyelectrolytes
Multilayers
Multilayer films
Nucleic acids
Proteins

PH and salt responsive peg sams on polyelectrolyte multilayer

Kidambi, S., Chan, C. & Lee, I. 2005 AIChE Annual Meeting, Conference Proceedings. p. 4685 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Polyelectrolytes
Multilayers
Electrolytes
Salts
Multilayer films

Regulation of apoptosis by free fatty acids and Tnf-α: Role of double-stranded RNA-dependent protein kinase (Pkr)

Yang, X., Li, Z., Srivastava, S. & Chan, C. 2005 AIChE Annual Meeting, Conference Proceedings. p. 8915-8916 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cell death
RNA
Fatty acids
Proteins
Phosphorylation
2004
64 Citations

Controlling primary hepatocyte adhesion and spreading on protein-free polyelectrolyte multilayer films

Kidambi, S., Lee, I. & Chan, C. Dec 22 2004 In : Journal of the American Chemical Society. 126, 50, p. 16286-16287 2 p.

Research output: Contribution to journalArticle

Styrene
Multilayer films
Polyelectrolytes
Hepatocytes
Adhesion
7 Citations

Extracting novel information from gene expression data

Li, Z. & Chan, C. Aug 1 2004 In : Trends in Biotechnology. 22, 8, p. 381-383 3 p.

Research output: Contribution to journalArticle

Gene expression
Transcription factors
Gene Expression
Transcription Factors
Network components
95 Citations

Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies

Chan, C., Berthiaume, F., Nath, B. D., Tilles, A. W., Toner, M. & Yarmush, M. L. Nov 2004 In : Liver Transplantation. 10, 11, p. 1331-1342 12 p.

Research output: Contribution to journalArticle

Tissue Engineering
Technology
Liver
Equipment and Supplies
Artificial Liver
34 Citations
Tricarboxylic Acids
Metabolic Networks and Pathways
Signal transduction
Reverse engineering
Testing
7 Citations

Insulin concentration during preconditioning mediates the regulation of urea synthesis during exposure to amino acid-supplemented plasma

Li, Z., Yarmush, M. L. & Chan, C. Nov 2004 In : Tissue Engineering. 10, 11-12, p. 1737-1746 10 p.

Research output: Contribution to journalArticle

Insulin
Urea
Amino acids
Plasmas
Amino Acids
21 Citations

Integrating gene expression and metabolic profiles

Li, Z. & Chan, C. Jun 25 2004 In : Journal of Biological Chemistry. 279, 26, p. 27124-27137 14 p.

Research output: Contribution to journalArticle

Metabolome
Transcriptome
Gene expression
Metabolic Networks and Pathways
Least-Squares Analysis
17 Citations

Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function

Hwang, D., Stephanopoulos, G. & Chan, C. Mar 1 2004 In : Bioinformatics. 20, 4, p. 487-499 13 p.

Research output: Contribution to journalArticle

Inverse Modeling
Multiblock
Environmental Factors
Least-Squares Analysis
Partial Least Squares
46 Citations
Ethylene Glycol
Self assembled monolayers
Polyelectrolytes
Polyethylene glycols
Multilayers
1 Citations

Selective primary hepatocyte adhesion on polyelectrolyte multilayer: Template for patterned cell co-culture

Kidambi, S., Lee, I. & Chan, C. 2004 AIChE Annual Meeting, Conference Proceedings. p. 8351-8355 5 p. 76f

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Polyelectrolytes
Styrene
Multilayers
Adhesion
Multilayer films
2003
39 Citations

Application of multivariate analysis to optimize function of cultured hepatocytes

Chan, C., Hwang, D., Stephanopoulos, G. N., Yarmush, M. L. & Stephanopoulos, G. Mar 2003 In : Biotechnology Progress. 19, 2, p. 580-598 19 p.

Research output: Contribution to journalArticle

hepatocytes
multivariate analysis
liver function
Hepatocytes
Multivariate Analysis
66 Citations

Metabolic Flux Analysis of Cultured Hepatocytes Exposed to Plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L. Jan 5 2003 In : Biotechnology and Bioengineering. 81, 1, p. 33-49 17 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Insulin
Hepatocytes
Fluxes
Plasmas
45 Citations

Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L. Jan 2003 In : Metabolic Engineering. 5, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Hormones
Amino acids
Hepatocytes
Fluxes
2002

Application of multivariate analysis for optimizing & predicting hepatic function

Chan, C., Hwang, D., Stephanopoulous, G., Stephanopoulous, G. N. & Yarmush, M. L. 2002 Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1, p. 724-725 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fluxes
Urea
Triglycerides
Discriminant analysis
Multivariate Analysis
Water recycling
Bioengineering
Insulin
Biotechnology
Lipids
27 Citations

Metabolic pre-conditioning of cultured cells in physiological levels of insulin: Generating resistance to the lipid-accumulating effects of plasma in hepatocytes

Chan, C., Berthiaume, F., Washizu, J., Toner, M. & Yarmush, M. L. Jun 30 2002 In : Biotechnology and Bioengineering. 78, 7, p. 753-760 8 p.

Research output: Contribution to journalArticle

Insulin
Lipids
Insulin Resistance
Hepatocytes
Cultured Cells
2001

Application of metabolic engineering to cellular processes of the liver: Bioartificial liver development

Chan, C., Washizu, J., Berthiaume, F., Toner, M. & Yarmush, M. L. 2001 American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Kamm, R. D., Schmid-Schoenbein, G. W., Atesian, G. A. & Hefzy, M. S. (eds.). Vol. 50, p. 357-358 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Metabolic engineering
Liver
Fluxes
Insulin
Collagen
2000
28 Citations

Amino acid supplementation improves cell-specific functions of the rat hepatocytes exposed to human plasma

Washizu, J., Chan, C., Berthiaume, F., Tompkins, R. G., Toner, M. & Yarmush, M. L. 2000 In : Tissue Engineering. 6, 5, p. 497-504 8 p.

Research output: Contribution to journalArticle

Plasma (human)
Amino acids
Rats
Hepatocytes
Amino Acids
27 Citations

Optimization of rat hepatocyte culture in citrated human plasma

Washizu, J., Berthiaume, F., Chan, C., Tompkins, R. G., Toner, M. & Yarmush, M. L. 2000 In : Journal of Surgical Research. 93, 2, p. 237-246 10 p.

Research output: Contribution to journalArticle

Hepatocytes
Artificial Liver
Culture Media
Urea
Albumins
1998
20 Citations

Essentially exact characteristics of turbulent convection in a round tube

Heng, L., Chan, C. & Churchill, S. W. Dec 18 1998 In : Chemical Engineering Journal. 71, 3, p. 163-173 11 p.

Research output: Contribution to journalArticle

Prandtl number
convection
Nusselt number
turbulent flow
Reynolds number
1996
5 Citations

Combustion of ethane with small concentrations of methyl chloride in a refractory tube burner

Brown, M. A., Chan, C., Targett, M. J., Holtzmuller, M. & Churchill, S. W. 1996 In : Combustion Science and Technology. 115, 4-6, p. 207-227 21 p.

Research output: Contribution to journalArticle

Methyl Chloride
methyl chloride
Ethane
burners
refractories
1995
27 Citations
turbulent flow
Turbulent flow
Shear stress
shear stress
Viscosity
30 Citations

Turbulent flow in channels in terms of local turbulent shear and normal stresses

Churchill, S. W. & Chan, C. Dec 1995 In : AICHE Journal. 41, 12, p. 2513-2521 9 p.

Research output: Contribution to journalArticle

Friction
Viscosity
Turbulent flow
Pressure
Shear stress
1994
15 Citations
turbulent flow
Turbulent flow
friction
Friction
Velocity distribution
1992
3 Citations

Thermally stabilized combustion as a means of studying the devolatilization of coal

Chan, C., Arai, N., Lior, N. & Churchill, S. W. Mar 1992 In : Industrial and Engineering Chemistry Research. 31, 3, p. 681-687 7 p.

Research output: Contribution to journalArticle

Coal
Carbon Monoxide
combustion
coal
Ethane