Publications 1992 2018

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  • 110 Article
  • 22 Conference contribution
  • 5 Chapter
  • 1 Review article
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2018

Schwann Cells Enhance Penetration of Regenerated Axons into Three-Dimensional Microchannels

Liu, C., Kray, J. & Chan, C. Jun 1 2018 In : Tissue Engineering and Regenerative Medicine. 15, 3, p. 351-361 11 p.

Research output: Contribution to journalArticle

Schwann Cells
Microchannels
Axons
Cells
Spinal Ganglia
2016
2 Citations

An approach to enhance alignment and myelination of dorsal root ganglion neurons

Liu, C. & Chan, C. Aug 24 2016 In : Journal of Visualized Experiments. 2016, 114, e54085

Research output: Contribution to journalArticle

Spinal Ganglia
Neurons
Axons
Schwann Cells
Demyelinating Diseases
1 Citations

Characterization of transcription factor response kinetics in parallel

Bilgin, B., Nath, A., Chan, C. & Walton, S. P. 2016 In : BMC Biotechnology. 16, 1, 62

Research output: Contribution to journalArticle

Transcription Factors
Palmitic Acid
Glucocorticoid Receptors
Tumor Necrosis Factor-alpha
TATA-Box Binding Protein
24 Citations
Fatty Acids
Genes
Neoplasms
Lipogenesis
Transcriptome
5 Citations

Haplotype-phased synthetic long reads from short-read sequencing

Stapleton, J. A., Kim, J., Hamilton, J. P., Wu, M., Irber, L. C., Maddamsetti, R., Briney, B., Newton, L., Burton, D. R., Brown, C. T., Chan, C., Buell, C. R. & Whitehead, T. A. Jan 1 2016 In : PLoS One. 11, 1, e0147229

Research output: Contribution to journalArticle

Haplotypes
haplotypes
Genes
env Genes
DNA
2 Citations

Schwann Cells Migration on Patterned Polydimethylsiloxane Microgrooved Surface

Liu, C., Kray, J., Toomajian, V. & Chan, C. Jul 1 2016 In : Tissue Engineering - Part C: Methods. 22, 7, p. 644-651 8 p.

Research output: Contribution to journalArticle

Schwann Cells
Polydimethylsiloxane
Cell Movement
Cells
Nerve Regeneration
2015
7 Citations

Brain derived neurotrophic factor release from layer-by-layer coated agarose nerve guidance scaffolds

Lynam, D. A., Shahriari, D., Wolf, K. J., Angart, P. A., Koffler, J., Tuszynski, M. H., Chan, C., Walton, P. & Sakamoto, J. May 1 2015 In : Acta Biomaterialia. 18, p. 128-131 4 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Scaffolds
Sepharose
Brain
Hydrogen
34 Citations

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Nath, A., Li, I., Roberts, L. R. & Chan, C. Oct 1 2015 In : Scientific Reports. 5, 14752

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Nonesterified Fatty Acids
Hepatocellular Carcinoma
Liver Neoplasms
Transforming Growth Factor beta
1 Citations

How can novel microscopic approaches shed light on the function of nucleic acid-based drugs?

Vocelle, D., Chan, C. & Walton, S. P. Sep 1 2015 In : Future Medicinal Chemistry. 7, 13, p. 1623-1625 3 p.

Research output: Contribution to journalArticle

Fluorescence Resonance Energy Transfer
Drug Discovery
RNA Interference
Transmission Electron Microscopy
Fluorescence Microscopy
3 Citations

Improving drug sensitivity prediction using different types of data

Hejase, H. A. & Chan, C. Feb 1 2015 In : CPT: Pharmacometrics and Systems Pharmacology. 4, 2, p. 98-105 8 p.

Research output: Contribution to journalArticle

Drugs
Cells
Cell Line
Lymphoma, Large B-Cell, Diffuse
Prediction
17 Citations

Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing

Kowalsky, C. A., Faber, M. S., Nath, A., Dann, H. E., Kelly, V. W., Liu, L., Shanker, P., Wagner, E. K., Maynard, J. A., Chan, C. & Whitehead, T. A. Oct 30 2015 In : Journal of Biological Chemistry. 290, 44, p. 26457-26470 14 p.

Research output: Contribution to journalArticle

Epitope Mapping
High-Throughput Nucleotide Sequencing
Mutagenesis
Epitopes
Antibodies
2014
64 Citations

A community computational challenge to predict the activity of pairs of compounds

Bansal, M. , Yang, J. , Karan, C. , Menden, M. P. , Costello, J. C. , Tang, H. , Xiao, G. , Li, Y. , Allen, J. , Zhong, R. , Chen, B. , Kim, M. , Wang, T. , Heiser, L. M. , Realubit, R. , Mattioli, M. , Alvarez, M. J. , Shen, Y. , Gallahan, D. , Singer, D. & 80 others Saez-Rodriguez, J., Xie, Y., Stolovitzky, G., Califano, A., Abbuehl, J. P., Altman, R. B., Balcome, S., Bell, A., Bender, A., Berger, B., Bernard, J., Bieberich, A. A., Borboudakis, G., Chan, C., Chen, T. H., Choi, J., Coelho, L. P., Creighton, C. J., Dampier, W., Davisson, V. J., Deshpande, R., Diao, L., Di Camillo, B., Dundar, M., Ertel, A., Goswami, C. P., Gottlieb, A., Gould, M. N., Goya, J., Grau, M., Gray, J. W., Hejase, H. A., Hoffmann, M. F., Homicsko, K., Homilius, M., Hwang, W., Ijzerman, A. P., Kallioniemi, O., Karacali, B., Kaski, S., Kim, J., Krishnan, A., Lee, J., Lee, Y. S., Lenselink, E. B., Lenz, P., Li, L., Li, J., Liang, H., Mpindi, J. P., Myers, C. L., Newton, M. A., Overington, J. P., Parkkinen, J., Prill, R. J., Peng, J., Pestell, R., Qiu, P., Rajwa, B., Sadanandam, A., Sambo, F., Sridhar, A., Sun, W., Toffolo, G. M., Tozeren, A., Troyanskaya, O. G., Tsamardinos, I., Van Vlijmen, H. W. T., Wang, W., Wegner, J. K., Wennerberg, K., Van Westen, G. J. P., Xia, T., Yang, Y., Yao, V., Yuan, Y., Zeng, H., Zhang, S., Zhao, J. & Zhou, J. Dec 1 2014 In : Nature Biotechnology. 32, 12, p. 1213-1222 10 p.

Research output: Contribution to journalArticle

Computer Simulation
Drug Combinations
Transcriptome
Gene expression
Screening
143 Citations

A community effort to assess and improve drug sensitivity prediction algorithms

Costello, J. C. , Heiser, L. M. , Georgii, E. , Gönen, M. , Menden, M. P. , Wang, N. J. , Bansal, M. , Ammad-Ud-Din, M. , Hintsanen, P. , Khan, S. A. , Mpindi, J. P. , Kallioniemi, O. , Honkela, A. , Aittokallio, T. , Wennerberg, K. , Collins, J. J. , Gallahan, D. , Singer, D. , Saez-Rodriguez, J. , Kaski, S. & 113 others Gray, J. W., Stolovitzky, G., Abbuehl, J. P., Allen, J., Altman, R. B., Balcome, S., Battle, A., Bender, A., Berger, B., Bernard, J., Bhattacharjee, M., Bhuvaneshwar, K., Bieberich, A. A., Boehm, F., Califano, A., Chan, C., Chen, B., Chen, T. H., Choi, J., Coelho, L. P., Cokelaer, T., Collins, J. C., Creighton, C. J., Cui, J., Dampier, W., Davisson, V. J., De Baets, B., Deshpande, R., DiCamillo, B., Dundar, M., Duren, Z., Ertel, A., Fan, H., Fang, H., Gauba, R., Gottlieb, A., Grau, M., Gusev, Y., Ha, M. J., Han, L., Harris, M., Henderson, N., Hejase, H. A., Homicsko, K., Hou, J. P., Hwang, W., IJzerman, A. P., Karacali, B., Keles, S., Kendziorski, C., Kim, J., Kim, M., Kim, Y., Knowles, D. A., Koller, D., Lee, J., Lee, J. K., Lenselink, E. B., Li, B., Li, B., Li, J., Liang, H., Ma, J., Madhavan, S., Mooney, S., Myers, C. L., Newton, M. A., Overington, J. P., Pal, R., Peng, J., Pestell, R., Prill, R. J., Qiu, P., Rajwa, B., Sadanandam, A., Sambo, F., Shin, H., Song, J., Song, L., Sridhar, A., Stock, M., Sun, W., Ta, T., Tadesse, M., Tan, M., Tang, H., Theodorescu, D., Toffolo, G. M., Tozeren, A., Trepicchio, W., Varoquaux, N., Vert, J. P., Waegeman, W., Walter, T., Wan, Q., Wang, D., Wang, W., Wang, Y., Wang, Z., Wegner, J. K., Wu, T., Xia, T., Xiao, G., Xie, Y., Xu, Y., Yang, J., Yuan, Y., Zhang, S., Zhang, X. S., Zhao, J., Zuo, C., Van Vlijmen, H. W. T. & Van Westen, G. J. P. Dec 1 2014 In : Nature Biotechnology. 32, 12, p. 1202-1212 11 p.

Research output: Contribution to journalArticle

Reverse engineering
Microarrays
Gene expression
Pharmaceutical Preparations
Medicine
9 Citations

Augmenting protein release from layer-by-layer functionalized agarose hydrogels

Lynam, D., Peterson, C., Maloney, R., Shahriari, D., Garrison, A., Saleh, S., Mehrotra, S., Chan, C. & Sakamoto, J. Mar 15 2014 In : Carbohydrate Polymers. 103, 1, p. 377-384 8 p.

Research output: Contribution to journalArticle

Hydrogels
Sepharose
Proteins
Gels
Hydrogel
1 Citations
Palmitates
Phosphotransferases
Fatty Acids
Binding Sites
Ligands
2 Citations

CREB modulates calcium signaling in cAMP-induced bone marrow stromal cells (BMSCs)

Zhang, L., Liu, L., Thompson, R. & Chan, C. Oct 1 2014 In : Cell Calcium. 56, 4, p. 257-268 12 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Calcium Signaling
Mesenchymal Stromal Cells
Cyclic AMP
Calcium
9 Citations

Distinguishing patients with Parkinson's disease subtypes from normal controls based on functional network regional efficiencies

Zhang, D., Liu, X., Chen, J., Liu, B. & Chan, C. Dec 22 2014 In : PLoS One. 9, 12, e115131

Research output: Contribution to journalArticle

Parkinson disease
Parkinson Disease
cerebellum
Cerebellum
Tremor
9 Citations

Effect of static pre-stretch induced surface anisotropy on orientation of mesenchymal stem cells

Liu, C., Baek, S., Kim, J., Vasko, E., Pyne, R. & Chan, C. 2014 In : Cellular and Molecular Bioengineering. 7, 1, p. 106-121 16 p.

Research output: Contribution to journalArticle

Stem Cells
Anisotropy
Stretch
Stem cells
Mesenchymal Stromal Cells
Inflammasomes
Neurobiology
Palmitates
Interleukin-1beta
Astrocytes
6 Citations

Improved asymmetry prediction for short interfering RNAs

Malefyt, A. P., Wu, M., Vocelle, D. B., Kappes, S. J., Lindeman, S. D., Chan, C. & Walton, S. P. Jan 2014 In : FEBS Journal. 281, 1, p. 320-330 11 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Thermodynamics
Thermodynamic stability
Nucleotides
RNA Interference

Improving drug sensitivity prediction using different types of data

Hejase, H. A. & Chan, C. 2014 In : CPT: Pharmacometrics and Systems Pharmacology. 3, 5, 666

Research output: Contribution to journalArticle

Drugs
Cells
Cell Line
Lymphoma, Large B-Cell, Diffuse
Prediction
26 Citations
Inflammasomes
Palmitates
Ice
Interleukin-1beta
Astrocytes
8 Citations

Prediction of therapeutic microRNA based on the human metabolic network

Wu, M. & Chan, C. 2014 In : Bioinformatics. 30, 8, p. 1163-1171 9 p.

Research output: Contribution to journalArticle

MicroRNA
Metabolic Network
Cell growth
Metabolic Networks and Pathways
MicroRNAs
4 Citations

Systematic modeling for the insulin signaling network mediated by IRS1 and IRS2

Huang, C., Wu, M., Du, J., Liu, D. & Chan, C. Aug 21 2014 In : Journal of Theoretical Biology. 355, p. 40-52 13 p.

Research output: Contribution to journalArticle

Insulin
insulin
Modeling
kinetics
Insulin Receptor
80 Citations

The role of inflammasome in Alzheimer's disease

Liu, L. & Chan, C. 2014 In : Ageing Research Reviews. 15, 1, p. 6-15 10 p.

Research output: Contribution to journalArticle

Inflammasomes
Neurology
Alzheimer Disease
Central Nervous System
Inflammation
2013
14 Citations

A classification framework applied to cancer gene expression profiles

Hijazi, H. & Chan, C. Jun 2013 In : Journal of Healthcare Engineering. 4, 2, p. 255-283 29 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Transcriptome
Gene expression
Support vector machines
Neoplasms
5 Citations

A multi-layer inference approach to reconstruct condition-specific genes and their regulation

Wu, M., Liu, L., Hijazi, H. & Chan, C. Jun 15 2013 In : Bioinformatics. 29, 12, p. 1541-1552 12 p.

Research output: Contribution to journalArticle

Multilayer
Genes
Gene
Breast Cancer
Breast Neoplasms
22 Citations

Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons

Patil, S. P., Tran, N., Geekiyanage, H., Liu, L. & Chan, C. Oct 25 2013 In : Neuroscience Letters. 554, p. 121-125 5 p.

Research output: Contribution to journalArticle

Curcumin
Up-Regulation
Polyphenols
Neurons
Alzheimer Disease
15 Citations

Design of siRNA therapeutics from the molecular scale

Angart, P., Vocelle, D., Chan, C. & Patrick Walton, S. Mar 25 2013 In : Pharmaceuticals. 6, 4, p. 440-468 29 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Therapeutics
Biological Phenomena
Drug Industry
RNA Interference
16 Citations

Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress

Pan, X., Whitten, D. A., Wu, M., Chan, C., Wilkerson, C. G. & Pestka, J. J. Sep 2013 In : Toxicological Sciences. 135, 1, p. 129-143 15 p.

Research output: Contribution to journalArticle

Spleen
Phosphorylation
Mitogen-Activated Protein Kinases
deoxynivalenol
Phosphatidylinositol 3-Kinase
21 Citations

Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage

Pan, X., Whitten, D. A., Wu, M., Chan, C., Wilkerson, C. G. & Pestka, J. J. Apr 5 2013 In : Toxicology and Applied Pharmacology. 268, 2, p. 201-211 11 p.

Research output: Contribution to journalArticle

Phosphorylation
Macrophages
Proteins
Trichothecenes
Isotope Labeling
24 Citations

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease

Geekiyanage, H., Upadhye, A. & Chan, C. Aug 2013 In : Neurobiology of Aging. 34, 8, p. 2037-2051 15 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
Amyloid
Alzheimer Disease
Ceramides
MicroRNAs
27 Citations

Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases

Liu, L., Martin, R. & Chan, C. Feb 2013 In : Neurobiology of Aging. 34, 2, p. 540-550 11 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
Sphingomyelin Phosphodiesterase
Palmitates
Astrocytes
Palmitic Acid
16 Citations

Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes

Liu, L., Martin, R., Kohler, G. & Chan, C. Oct 2013 In : Experimental Neurology. 248, p. 482-490 9 p.

Research output: Contribution to journalArticle

Presenilins
Palmitates
Astrocytes
Alzheimer Disease
Presenilin-1
7 Citations

Quantitative, solution-phase profiling of multiple transcription factors in parallel

Bilgin, B., Liu, L., Chan, C. & Patrick Walton, S. Mar 2013 In : Analytical and Bioanalytical Chemistry. 405, 8, p. 2461-2468 8 p.

Research output: Contribution to journalArticle

Transcription Factors
Assays
Genes
Amplification
Breast Neoplasms
16 Citations

Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells

Cho, H., Wu, M., Zhang, L., Thompson, R., Nath, A. & Chan, C. Jan 22 2013 In : BMC Systems Biology. 7, 9

Research output: Contribution to journalArticle

Activating Transcription Factor 4
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Transcription factors
Palmitates
2012
140 Citations

Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

Geekiyanage, H., Jicha, G. A., Nelson, P. T. & Chan, C. Jun 2012 In : Experimental Neurology. 235, 2, p. 491-496 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Alzheimer Disease
Biomarkers
Serum
Aptitude
3 Citations

Ensemble classification of cancer types and biomarker identification

Hijazi, H., Wu, M., Nath, A. & Chan, C. Nov 2012 In : Drug Development Research. 73, 7, p. 414-419 6 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Biomarkers
Neoplasms
Drug Design
Research
10 Citations

Latest developments in experimental and computational approaches to characterize protein-lipid interactions

Cho, H., Wu, M., Bilgin, B., Walton, S. P. & Chan, C. Nov 2012 In : Proteomics. 12, 22, p. 3273-3285 13 p.

Research output: Contribution to journalArticle

Lipids
Proteins
Technology
Molecules
DNA
10 Citations

Learning transcriptional regulation on a genome scale: A theoretical analysis based on gene expression data

Wu, M. & Chan, C. Mar 2012 In : Briefings in Bioinformatics. 13, 2, p. 150-161 12 p., bbr029

Research output: Contribution to journalArticle

Data Mining
Gene Regulatory Networks
Gene Expression Profiling
Microarrays
MicroRNAs
3 Citations

Oligomerization of the transmembrane domain of IRE1α in SDS micelles

Cho, H., LaMarca, R. & Chan, C. Nov 2 2012 In : Biochemical and Biophysical Research Communications. 427, 4, p. 764-767 4 p.

Research output: Contribution to journalArticle

Oligomerization
Micelles
Unfolded Protein Response
Proteins
Inositol
16 Citations

Time controlled release of arabinofuranosylcytosine (Ara-C) from agarose hydrogels using layer-by-layer assembly: An in vitro study

Mehrotra, S., Lynam, D., Liu, C., Shahriari, D., Lee, I., Tuszynski, M., Sakamoto, J. & Chan, C. 2012 In : Journal of Biomaterials Science, Polymer Edition. 23, 1-4, p. 439-463 25 p.

Research output: Contribution to journalArticle

Hydrogels
Cytarabine
Sepharose
Cells
Fibroblasts
2011
24 Citations

CAMP initiates early phase neuron-like morphology changes and late phase neural differentiation in mesenchymal stem cells

Zhang, L., Seitz, L. C., Abramczyk, A. M., Liu, L. & Chan, C. Mar 2011 In : Cellular and Molecular Life Sciences. 68, 5, p. 863-876 14 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Neurons
Potassium Chloride
Second Messenger Systems
Cyclic AMP-Dependent Protein Kinases
15 Citations

Identification of novel targets for breast cancer by exploring gene switches on a genome scale

Wu, M., Liu, L. & Chan, C. Nov 3 2011 In : BMC Genomics. 12, 547

Research output: Contribution to journalArticle

Neoplasm Genes
Switch Genes
Genome
Breast Neoplasms
Transducers
128 Citations

Micro RNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β novel targets in sporadic Alzheimer's disease

Geekiyanage, H. & Chan, C. Oct 12 2011 In : Journal of Neuroscience. 31, 41, p. 14820-14830 11 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
MicroRNAs
Amyloid
Alzheimer Disease
Ceramides
3 Citations

Molecular mechanism by which palmitate inhibits PKR autophosphorylation

Cho, H., Mukherjee, S., Palasuberniam, P., Pillow, L., Bilgin, B., Nezich, C., Walton, S. P., Feig, M. & Chan, C. Feb 15 2011 In : Biochemistry. 50, 6, p. 1110-1119 10 p.

Research output: Contribution to journalArticle

Palmitates
Phosphotransferases
Adenosine Triphosphate
Binding Sites
eIF-2 Kinase
6 Citations

Polyelectrolyte multilayer stamping in aqueous phase and non-contact mode

Mehrotra, S., Lee, I., Liu, C. & Chan, C. Aug 3 2011 In : Industrial and Engineering Chemistry Research. 50, 15, p. 8851-8858 8 p.

Research output: Contribution to journalArticle

Stamping
Polyelectrolytes
Multilayers
Scaffolds
Substrates
4 Citations

Synergy analysis reveals association between insulin signaling and desmoplakin expression in palmitate treated HepG2 cells

Wang, X., Nath, A., Yang, X., Portis, A., Walton, S. P. & Chan, C. Nov 23 2011 In : PLoS One. 6, 11, e28138

Research output: Contribution to journalArticle

Desmoplakins
Palmitates
palmitates
Hep G2 Cells
insulin
2010
8 Citations

Cancer-drug associations: A complex system

Dalkic, E., Wang, X., Wright, N. & Chan, C. 2010 In : PLoS One. 5, 4, e10031

Research output: Contribution to journalArticle

Large scale systems
drugs
neoplasms
Pharmaceutical Preparations
Neoplasms
37 Citations

Cell adhesive behavior on thin polyelectrolyte multilayers: Cells attempt to achieve homeostasis of its adhesion energy

Mehrotra, S., Hunley, S. C., Pawelec, K. M., Zhang, L., Lee, I., Baek, S. & Chan, C. Aug 3 2010 In : Langmuir. 26, 15, p. 12794-12802 9 p.

Research output: Contribution to journalArticle

homeostasis
Polyelectrolytes
Adhesives
adhesives
Multilayers