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Publications 1992 2018

  • 31 h-Index
  • 110 Article
  • 22 Conference contribution
  • 5 Chapter
  • 1 Review article
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Article
2010
14 Citations

Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles

Portis, A. M., Carballo, G., Baker, G. L., Chan, C. & Walton, S. P., Sep 2010, In : Microscopy Research and Technique. 73, 9, p. 878-885 8 p.

Research output: Contribution to journalArticle

Confocal microscopy
RNA
Confocal Microscopy
Nanoparticles
Small Interfering RNA
48 Citations

Designing highly active siRNAs for therapeutic applications

Patrick Walton, S., Wu, M., Gredell, J. A. & Chan, C., Dec 2010, In : FEBS Journal. 277, 23, p. 4806-4813 8 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Therapeutics
RNA Interference
RNA
Thermodynamics
2 Citations

Erratum: Time controlled protein release from layer-by-layer assembled multilayer functionalized agarose hydrogels (Advanced Functional Materials (2010) 20 (247) 10.1002/adfm.200901172)

Mehrotra, S., Lynam, D., Maloney, R., Pawelec, K. M., Tuszynski, M. H., Lee, I., Chan, C. & Sakamoto, J., Mar 24 2010, In : Advanced Functional Materials. 20, 6, p. 878 1 p.

Research output: Contribution to journalArticle

Functional materials
Hydrogels
Multilayers
proteins
Proteins
50 Citations
Cell Separation
Stem cells
Mesenchymal Stromal Cells
Rats
Hematopoietic Stem Cells
11 Citations
Cell Separation
Stem cells
Mesenchymal Stromal Cells
Rats
Hematopoietic Stem Cells
35 Citations

Recognition of siRNA asymmetry by TAR RNA binding protein

Gredell, J. A., Dittmer, M. J., Wu, M., Chan, C. & Walton, S. P., Apr 13 2010, In : Biochemistry. 49, 14, p. 3148-3155 8 p.

Research output: Contribution to journalArticle

Small Interfering RNA
RNA-Induced Silencing Complex
RNA Interference
RNA
Reduced instruction set computing
25 Citations

Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells

Zhang, L., Seitz, L. C., Abramczyk, A. M. & Chan, C., Mar 10 2010, In : Experimental Cell Research. 316, 5, p. 716-727 12 p.

Research output: Contribution to journalArticle

Palmitates
Hep G2 Cells
Organelle Biogenesis
Cell Death
Reactive Oxygen Species
25 Citations

The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells

Yang, X., Nath, A., Opperman, M. J. & Chan, C., Oct 1 2010, In : Molecular Biology of the Cell. 21, 19, p. 3449-3458 10 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
Insulin Receptor Substrate Proteins
Double-Stranded RNA
Hep G2 Cells
Phosphorylation
70 Citations

Time controlled protein release from layer-by-layer assembled multilayer functionalized agarose hydrogels

Mehrotra, S., Lynam, D., Maloney, R., Pawelec, K. M., Tuszynski, M. H., Lee, I., Chan, C. & Sakamoto, J., Jan 22 2010, In : Advanced Functional Materials. 20, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

Hydrogels
Sepharose
Multilayers
proteins
Proteins
41 Citations

Withanolide a and asiatic acid modulate multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearance

Patil, S. P., Maki, S., Khedkar, S. A., Rigby, A. C. & Chan, C., Jul 23 2010, In : Journal of Natural Products. 73, 7, p. 1196-1202 7 p.

Research output: Contribution to journalArticle

Withanolides
Amyloid beta-Protein Precursor
Amyloid beta-Peptides
Alzheimer Disease
Processing
2009
23 Citations

A dynamic analysis of IRS-PKR signaling in liver cells: A discrete modeling approach

Wu, M., Yang, X. & Chan, C., 2009, In : PLoS One. 4, 12, e8040

Research output: Contribution to journalArticle

Liver
Dynamic analysis
hepatocytes
Insulin
insulin

Integrative analysis of cancer pathway progression and coherence

Dalkic, E., Walter Nash, D. E., Fassia, M. K. & Chan, C., 2009, In : Proteomics - Clinical Applications. 3, 4, p. 473-485 13 p.

Research output: Contribution to journalArticle

Encyclopedias
Colorectal Neoplasms
Genes
Genome
Carcinoma
41 Citations

Multilayer mediated forward and patterned siRNA transfection using linear-PEI at extended N/P ratios

Mehrotra, S., Lee, I. & Chan, C., Jun 2009, In : Acta Biomaterialia. 5, 5, p. 1474-1488 15 p.

Research output: Contribution to journalArticle

Polyetherimides
RNA
Small Interfering RNA
Transfection
Multilayers
15 Citations

Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization

Yang, X., Zhou, Y., Jin, R. & Chan, C., 2009, In : Bioinformatics. 25, 17, p. 2236-2243 8 p.

Research output: Contribution to journalArticle

Gene Networks
Matrix Factorization
Gene Regulatory Networks
Factorization
Phenotype
27 Citations

Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2

Yang, X. & Chan, C., Apr 2009, In : Cell Research. 19, 4, p. 469-486 18 p.

Research output: Contribution to journalArticle

Palmitates
Hep G2 Cells
Phosphorylation
Apoptosis
eIF-2 Kinase
33 Citations

The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes

Leekumjorn, S., Cho, H. J., Wu, Y., Wright, N. T., Sum, A. K. & Chan, C., Jul 2009, In : Biochimica et Biophysica Acta - Biomembranes. 1788, 7, p. 1508-1516 9 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Fatty Acids
Oleic Acid
Membranes
Liposomes
2008
4 Citations

A bayesian framework for knowledge driven regression model in micro-array data analysis

Jin, R., Si, L. & Chan, C., 2008, In : International Journal of Data Mining and Bioinformatics. 2, 3, p. 250-267 18 p.

Research output: Contribution to journalArticle

Linear regression
Linear Models
data analysis
regression
Gene expression
10 Citations

A novel method incorporating gene ontology information for unsupervised clustering and feature selection

Srivastava, S., Zhang, L., Jin, R. & Chan, C., Dec 4 2008, In : PLoS One. 3, 12, e3860

Research output: Contribution to journalArticle

Gene Ontology
Cluster Analysis
Ontology
Feature extraction
Genes
30 Citations

Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line

Srivastava, S. & Chan, C., Feb 1 2008, In : Biotechnology and Bioengineering. 99, 2, p. 399-410 12 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Fatty acids
Nonesterified Fatty Acids
Toxicity
Hepatocellular Carcinoma
15 Citations

Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease

Patil, S., Balu, D., Melrose, J. & Chan, C., 2008, In : BMC Research Notes. 1, 20

Research output: Contribution to journalArticle

Palmitic Acid
Brain
Alzheimer Disease
Astrocytes
Cerebellum
26 Citations

Experimental and computational studies investigating trehalose protection of HepG2 cells from palmitate-induced toxicity

Leekumjorn, S., Wu, Y., Sum, A. K. & Chan, C., Apr 2008, In : Biophysical Journal. 94, 7, p. 2869-2883 15 p.

Research output: Contribution to journalArticle

Trehalose
Palmitates
Hep G2 Cells
Hepatocytes
Cell Membrane
61 Citations

Gene module level analysis: identification to networks and dynamics

Wang, X., Dalkic, E., Wu, M. & Chan, C., Oct 2008, In : Current Opinion in Biotechnology. 19, 5, p. 482-491 10 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Biological systems
Genes
Molecular Medicine
Inborn Genetic Diseases
37 Citations
Oxidative stress
Polyelectrolytes
Styrene
neurons
Neurons
29 Citations

Short time-series microarray analysis: Methods and challenges

Wang, X., Wu, M., Li, Z. & Chan, C., Jul 7 2008, In : BMC Systems Biology. 2, 58

Research output: Contribution to journalArticle

Microarray Analysis
Time Series Analysis
Microarrays
Time Series Data
Time series
16 Citations
Polyelectrolytes
Polyethylene glycols
glycols
Multilayers
ethylene
10 Citations

Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity

Li, Z., Srivastava, S., Findlan, R. & Chan, C., Jan 2008, In : Biotechnology Progress. 24, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Nonesterified Fatty Acids
Palmitates
palmitates
free fatty acids
2007
18 Citations

A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells

Li, Z., Srivastava, S., Yang, X., Mittal, S., Norton, P., Resau, J., Haab, B. & Chan, C., May 11 2007, In : BMC Systems Biology. 1, 21

Research output: Contribution to journalArticle

Cytotoxicity
Gene Expression Profile
Tumor Necrosis Factor
Hep G2 Cells
Fatty Acids
18 Citations

A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways

Li, Z., Srivastava, S., Mittal, S., Yang, X., Sheng, L. & Chan, C., Jun 14 2007, In : BMC Bioinformatics. 8, 202

Research output: Contribution to journalArticle

Toxicity
Metabolites
Gene expression
Pathway
Genes
57 Citations

Cell adhesion on polyelectrolyte multilayer coated polydimethylsiloxane surfaces with varying topographies

Kidambi, S., Udpa, N., Schroeder, S. A., Findlan, R., Lee, I. & Chan, C., Aug 2007, In : Tissue Engineering. 13, 8, p. 2105-2117 13 p.

Research output: Contribution to journalArticle

Cell adhesion
Polydimethylsiloxane
Polyelectrolytes
Cell Adhesion
Topography
52 Citations
Palmitates
Cytotoxicity
Hydroxyl Radical
Hydrogen Peroxide
Hepatocellular Carcinoma
9 Citations

Identification of genes that regulate multiple cellular processes/ responses in the context of lipotoxicity to hepatoma cells

Srivastava, S., Li, Z., Yang, X., Yedwabnick, M., Shaw, S. & Chan, C., Oct 9 2007, In : BMC Genomics. 8, 364

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Nonesterified Fatty Acids
Triglycerides
NADH Dehydrogenase
Genes
67 Citations

Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons

Patil, S., Melrose, J. & Chan, C., Oct 2007, In : European Journal of Neuroscience. 26, 8, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

Palmitic Acid
Ceramides
Alzheimer Disease
Neurons
Nonesterified Fatty Acids
57 Citations

Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates

Kidambi, S., Sheng, L., Yarmush, M. L., Toner, M., Lee, I. & Chan, C., Mar 8 2007, In : Macromolecular Bioscience. 7, 3, p. 344-353 10 p.

Research output: Contribution to journalArticle

Polystyrenes
Fibroblasts
Coculture Techniques
Polyelectrolytes
Cell culture
2006
1 Citations

Biological network analyses: Computational genomics and systems approaches

Walton, S. P., Li, Z. & Chan, C., Jan 1 2006, In : Molecular Simulation. 32, 3-4, p. 203-209 7 p.

Research output: Contribution to journalArticle

Biological Networks
Genomics
Throughput
chemical engineering
Chemical engineering
4 Citations

Cellular to tissue informatics: Approaches to optimizing cellular function of engineered tissue

Patil, S., Li, Z. & Chan, C., Jul 15 2006, In : Advances in Biochemical Engineering/Biotechnology. 102, p. 139-159 21 p.

Research output: Contribution to journalArticle

Informatics
Tissue
Tissue Engineering
Tissue engineering
Artificial Skin
59 Citations

Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons

Patil, S., Sheng, L., Masserang, A. & Chan, C., Oct 2 2006, In : Neuroscience Letters. 406, 1-2, p. 55-59 5 p.

Research output: Contribution to journalArticle

Palmitic Acid
Amyloid beta-Protein Precursor
Astrocytes
Alzheimer Disease
Up-Regulation
34 Citations

Using a state-space model with hidden variables to infer transcription factor activities

Li, Z., Shaw, S. M., Yedwabnick, M. J. & Chan, C., Mar 15 2006, In : Bioinformatics. 22, 6, p. 747-754 8 p.

Research output: Contribution to journalArticle

Space Simulation
Hidden Variables
Transcription factors
State-space Model
Transcription Factor
2005
Metabolome
Transcriptome
65 Citations

Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons

Patil, S. & Chan, C., Aug 26 2005, In : Neuroscience Letters. 384, 3, p. 288-293 6 p.

Research output: Contribution to journalArticle

Stearic Acids
Nonesterified Fatty Acids
Alzheimer Disease
Neurons
Fatty Acids
2004
64 Citations

Controlling primary hepatocyte adhesion and spreading on protein-free polyelectrolyte multilayer films

Kidambi, S., Lee, I. & Chan, C., Dec 22 2004, In : Journal of the American Chemical Society. 126, 50, p. 16286-16287 2 p.

Research output: Contribution to journalArticle

Styrene
Multilayer films
Polyelectrolytes
Hepatocytes
Adhesion
7 Citations

Extracting novel information from gene expression data

Li, Z. & Chan, C., Aug 1 2004, In : Trends in Biotechnology. 22, 8, p. 381-383 3 p.

Research output: Contribution to journalArticle

Gene expression
Transcription factors
Gene Expression
Transcription Factors
Network components
96 Citations

Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies

Chan, C., Berthiaume, F., Nath, B. D., Tilles, A. W., Toner, M. & Yarmush, M. L., Nov 2004, In : Liver Transplantation. 10, 11, p. 1331-1342 12 p.

Research output: Contribution to journalArticle

Tissue Engineering
Technology
Liver
Equipment and Supplies
Artificial Liver
34 Citations
Tricarboxylic Acids
Metabolic Networks and Pathways
Signal transduction
Reverse engineering
Testing
7 Citations

Insulin concentration during preconditioning mediates the regulation of urea synthesis during exposure to amino acid-supplemented plasma

Li, Z., Yarmush, M. L. & Chan, C., Nov 2004, In : Tissue Engineering. 10, 11-12, p. 1737-1746 10 p.

Research output: Contribution to journalArticle

Insulin
Urea
Amino acids
Plasmas
Amino Acids
21 Citations

Integrating gene expression and metabolic profiles

Li, Z. & Chan, C., Jun 25 2004, In : Journal of Biological Chemistry. 279, 26, p. 27124-27137 14 p.

Research output: Contribution to journalArticle

Metabolome
Transcriptome
Gene expression
Metabolic Networks and Pathways
Least-Squares Analysis
17 Citations

Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function

Hwang, D., Stephanopoulos, G. & Chan, C., Mar 1 2004, In : Bioinformatics. 20, 4, p. 487-499 13 p.

Research output: Contribution to journalArticle

Inverse Modeling
Multiblock
Environmental Factors
Least-Squares Analysis
Partial Least Squares
46 Citations

Selective Depositions on Polyelectrolyte Multilayers: Self-Assembled Monolayers of m-dPEG Acid as Molecular Template

Kidambi, S., Chan, C. & Lee, I., Apr 14 2004, In : Journal of the American Chemical Society. 126, 14, p. 4697-4703 7 p.

Research output: Contribution to journalArticle

Ethylene Glycol
Self assembled monolayers
Polyelectrolytes
Polyethylene glycols
Multilayers
2003
40 Citations

Application of multivariate analysis to optimize function of cultured hepatocytes

Chan, C., Hwang, D., Stephanopoulos, G. N., Yarmush, M. L. & Stephanopoulos, G., Mar 2003, In : Biotechnology Progress. 19, 2, p. 580-598 19 p.

Research output: Contribution to journalArticle

hepatocytes
multivariate analysis
liver function
Hepatocytes
Multivariate Analysis
67 Citations

Metabolic Flux Analysis of Cultured Hepatocytes Exposed to Plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L., Jan 5 2003, In : Biotechnology and Bioengineering. 81, 1, p. 33-49 17 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Insulin
Hepatocytes
Fluxes
Plasmas
46 Citations

Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L., Jan 2003, In : Metabolic Engineering. 5, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Hormones
Amino acids
Hepatocytes
Fluxes