Publications 1992 2016

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2010
46 Citations

Designing highly active siRNAs for therapeutic applications

Patrick Walton, S., Wu, M., Gredell, J. A. & Chan, C. Dec 2010 In : FEBS Journal. 277, 23, p. 4806-4813 8 p.

Research output: Contribution to journalArticle

Small Interfering RNA
RNA Interference
Thermodynamics
Messenger RNA
Inborn Errors Amino Acid Metabolism
2 Citations

Erratum: Time controlled protein release from layer-by-layer assembled multilayer functionalized agarose hydrogels (Advanced Functional Materials (2010) 20 (247) 10.1002/adfm.200901172)

Mehrotra, S., Lynam, D., Maloney, R., Pawelec, K. M., Tuszynski, M. H., Lee, I., Chan, C. & Sakamoto, J. Mar 24 2010 In : Advanced Functional Materials. 20, 6, p. 878 1 p.

Research output: Contribution to journalArticle

29 Citations
Cell Separation
Mesenchymal Stromal Cells
Status Epilepticus
Stem cells
Hematopoietic Stem Cells
4 Citations
Cell Separation
Mesenchymal Stromal Cells
Status Epilepticus
Stem cells
Hematopoietic Stem Cells
32 Citations

Recognition of siRNA asymmetry by TAR RNA binding protein

Gredell, J. A., Dittmer, M. J., Wu, M., Chan, C. & Walton, S. P. Apr 13 2010 In : Biochemistry. 49, 14, p. 3148-3155 8 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Small Interfering RNA
RNA-Induced Silencing Complex
Proteins
Bibliography of Medicine
23 Citations

Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells

Zhang, L., Seitz, L. C., Abramczyk, A. M. & Chan, C. Mar 10 2010 In : Experimental Cell Research. 316, 5, p. 716-727 12 p.

Research output: Contribution to journalArticle

Palmitates
Hep G2 Cells
Cell Death
Mitochondrial Turnover
Reactive Oxygen Species
24 Citations

The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells

Yang, X., Nath, A., Opperman, M. J. & Chan, C. Oct 1 2010 In : Molecular Biology of the Cell. 21, 19, p. 3449-3458 10 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
Insulin Receptor Substrate Proteins
Double-Stranded RNA
Hep G2 Cells
Phosphorylation
65 Citations

Time controlled protein release from layer-by-layer assembled multilayer functionalized agarose hydrogels

Mehrotra, S., Lynam, D., Maloney, R., Pawelec, K. M., Tuszynski, M. H., Lee, I., Chan, C. & Sakamoto, J. Jan 22 2010 In : Advanced Functional Materials. 20, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

Proteins
proteins
Hydrogels
Multilayers
axons
30 Citations

Withanolide a and asiatic acid modulate multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearance

Patil, S. P., Maki, S., Khedkar, S. A., Rigby, A. C. & Chan, C. Jul 23 2010 In : Journal of Natural Products. 73, 7, p. 1196-1202 7 p.

Research output: Contribution to journalArticle

Withanolides
Amyloid beta-Protein Precursor
Amyloid beta-Peptides
Alzheimer Disease
Acids
2009
21 Citations

A dynamic analysis of IRS-PKR signaling in liver cells: A discrete modeling approach

Wu, M., Yang, X. & Chan, C. 2009 In : PLoS One. 4, 12, e8040

Research output: Contribution to journalArticle

Insulin
Liver
Spontaneous Fractures
insulin
Fibrin

Integrative analysis of cancer pathway progression and coherence

Dalkic, E., Walter Nash, D. E., Fassia, M. K. & Chan, C. 2009 In : Proteomics - Clinical Applications. 3, 4, p. 473-485 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasms
Cyclic AMP Receptor Protein
Encyclopedias
Genome
39 Citations

Multilayer mediated forward and patterned siRNA transfection using linear-PEI at extended N/P ratios

Mehrotra, S., Lee, I. & Chan, C. Jun 2009 In : Acta Biomaterialia. 5, 5, p. 1474-1488 15 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Transfection
RNA
Nanoparticles
Myosins
14 Citations

Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization

Yang, X., Zhou, Y., Jin, R. & Chan, C. 2009 In : Bioinformatics. 25, 17, p. 2236-2243 8 p.

Research output: Contribution to journalArticle

Matrix factorization
Gene Regulatory Networks
Phenotype
Cyclic AMP Receptor Protein
Genes
24 Citations

Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2

Yang, X. & Chan, C. Apr 2009 In : Cell Research. 19, 4, p. 469-486 18 p.

Research output: Contribution to journalArticle

Palmitates
Hep G2 Cells
Phosphorylation
Apoptosis
Proteins
25 Citations

The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes

Leekumjorn, S., Cho, H. J., Wu, Y., Wright, N. T., Sum, A. K. & Chan, C. Jul 2009 In : Biochimica et Biophysica Acta - Biomembranes. 1788, 7, p. 1508-1516 9 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Fatty Acids
Membranes
Bronchiolo-Alveolar Adenocarcinoma
Oleic Acid
2008
4 Citations

A bayesian framework for knowledge driven regression model in micro-array data analysis

Jin, R., Si, L. & Chan, C. 2008 In : International Journal of Data Mining and Bioinformatics. 2, 3, p. 250-267 18 p.

Research output: Contribution to journalArticle

Anthralin
Linear regression
regression
Linear Models
data
10 Citations

A novel method incorporating gene ontology information for unsupervised clustering and feature selection

Srivastava, S., Zhang, L., Jin, R. & Chan, C. Dec 4 2008 In : PLoS One. 3, 12, e3860

Research output: Contribution to journalArticle

Gene Ontology
Cluster Analysis
Genes
genes
Cyclic AMP Receptor Protein
28 Citations

Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line

Srivastava, S. & Chan, C. Feb 1 2008 In : Biotechnology and Bioengineering. 99, 2, p. 399-410 12 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Nonesterified Fatty Acids
Hepatocellular Carcinoma
Fatty Acids
Cell Line
14 Citations

Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease

Patil, S., Balu, D., Melrose, J. & Chan, C. 2008 In : BMC Research Notes. 1, 20

Research output: Contribution to journalArticle

Palmitic Acid
Alzheimer Disease
Brain
Supravalvular Aortic Stenosis
Astrocytes
24 Citations

Experimental and computational studies investigating trehalose protection of HepG2 cells from palmitate-induced toxicity

Leekumjorn, S., Wu, Y., Sum, A. K. & Chan, C. Apr 2008 In : Biophysical Journal. 94, 7, p. 2869-2883 15 p.

Research output: Contribution to journalArticle

Trehalose
Palmitates
Hep G2 Cells
Hepatocytes
Cell Membrane
58 Citations

Gene module level analysis: identification to networks and dynamics

Wang, X., Dalkic, E., Wu, M. & Chan, C. Oct 2008 In : Current Opinion in Biotechnology. 19, 5, p. 482-491 10 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Cyclic AMP Receptor Protein
Genes
Catatonia
Biological systems
35 Citations
Neurons
neurons
Nitrogenase
Styrene
polystyrene
26 Citations

Short time-series microarray analysis: Methods and challenges

Wang, X., Wu, M., Li, Z. & Chan, C. Jul 7 2008 In : BMC Systems Biology. 2, 58

Research output: Contribution to journalArticle

Time series data
Time series
Microarray Analysis
Microarrays
Time series analysis
15 Citations
Polyethylene glycols
Polyelectrolytes
Magnesium Deficiency
Edema Disease of Swine
glycols
10 Citations

Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity

Li, Z., Srivastava, S., Findlan, R. & Chan, C. Jan 2008 In : Biotechnology Progress. 24, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Nonesterified Fatty Acids
free fatty acids
Palmitates
palmitates
2007
18 Citations

A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells

Li, Z., Srivastava, S., Yang, X., Mittal, S., Norton, P., Resau, J., Haab, B. & Chan, C. May 11 2007 In : BMC Systems Biology. 1, 21

Research output: Contribution to journalArticle

Hep G2 Cells
Transcriptome
Tumor Necrosis Factor-alpha
Fatty acids
Genes
18 Citations

A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways

Li, Z., Srivastava, S., Mittal, S., Yang, X., Sheng, L. & Chan, C. Jun 14 2007 In : BMC Bioinformatics. 8, 202

Research output: Contribution to journalArticle

Cyclic AMP Receptor Protein
Genes
Genome
Technology
Proteins
54 Citations

Cell adhesion on polyelectrolyte multilayer coated polydimethylsiloxane surfaces with varying topographies

Kidambi, S., Udpa, N., Schroeder, S. A., Findlan, R., Lee, I. & Chan, C. Aug 2007 In : Tissue Engineering. 13, 8, p. 2105-2117 13 p.

Research output: Contribution to journalArticle

Polydimethylsiloxane
Cell Adhesion
Cell Proliferation
Cell adhesion
Substrates
51 Citations
Palmitates
Hydroxyl Radical
Hydrogen Peroxide
Hepatocellular Carcinoma
Permeability
9 Citations

Identification of genes that regulate multiple cellular processes/ responses in the context of lipotoxicity to hepatoma cells

Srivastava, S., Li, Z., Yang, X., Yedwabnick, M., Shaw, S. & Chan, C. Oct 9 2007 In : BMC Genomics. 8, 364

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Genes
Nonesterified Fatty Acids
Triglycerides
Tumor Necrosis Factor-alpha
60 Citations

Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons

Patil, S., Melrose, J. & Chan, C. Oct 2007 In : European Journal of Neuroscience. 26, 8, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

Palmitic Acid
Ceramides
Alzheimer Disease
Neurons
Nonesterified Fatty Acids
53 Citations

Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates

Kidambi, S., Sheng, L., Yarmush, M. L., Toner, M., Lee, I. & Chan, C. Mar 8 2007 In : Macromolecular Bioscience. 7, 3, p. 344-353 10 p.

Research output: Contribution to journalArticle

Polystyrenes
Coculture Techniques
Hepatocytes
Fibroblasts
Edema Disease of Swine
2006
Microarray Analysis
Linear Models
Gene Expression
Genes
Linear regression
1 Citations

Biological network analyses: Computational genomics and systems approaches

Walton, S. P., Li, Z. & Chan, C. Jan 1 2006 In : Molecular Simulation. 32, 3-4, p. 203-209 7 p.

Research output: Contribution to journalArticle

Throughput
Lutheran Blood-Group System
Caprylates
Metabolomics
Systems Biology
4 Citations

Cellular to tissue informatics: Approaches to optimizing cellular function of engineered tissue

Patil, S., Li, Z. & Chan, C. Jul 15 2006 In : Advances in Biochemical Engineering/Biotechnology. 102, p. 139-159 21 p.

Research output: Contribution to journalArticle

Library Catalogs
Tissue
Tissue Engineering
Myoclonic Cerebellar Dyssynergia
Tissue engineering
57 Citations

Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons

Patil, S., Sheng, L., Masserang, A. & Chan, C. Oct 2 2006 In : Neuroscience Letters. 406, 1-2, p. 55-59 5 p.

Research output: Contribution to journalArticle

Palmitic Acid
Amyloid beta-Protein Precursor
Astrocytes
Alzheimer Disease
Up-Regulation
32 Citations

Using a state-space model with hidden variables to infer transcription factor activities

Li, Z., Shaw, S. M., Yedwabnick, M. J. & Chan, C. Mar 15 2006 In : Bioinformatics. 22, 6, p. 747-754 8 p.

Research output: Contribution to journalArticle

State-space model
Space Simulation
Transcription Factors
Anthralin
Transcription factor
61 Citations

Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons

Patil, S. & Chan, C. Aug 26 2005 In : Neuroscience Letters. 384, 3, p. 288-293 6 p.

Research output: Contribution to journalArticle

Stearic Acids
Nonesterified Fatty Acids
Alzheimer Disease
Neurons
Fatty Acids
2004
60 Citations

Controlling primary hepatocyte adhesion and spreading on protein-free polyelectrolyte multilayer films

Kidambi, S., Lee, I. & Chan, C. Dec 22 2004 In : Journal of the American Chemical Society. 126, 50, p. 16286-16287 2 p.

Research output: Contribution to journalArticle

Styrene
Hepatocytes
Proteins
Edema Disease of Swine
Chlorides
7 Citations

Extracting novel information from gene expression data

Li, Z. & Chan, C. Aug 1 2004 In : Trends in Biotechnology. 22, 8, p. 381-383 3 p.

Research output: Contribution to journalArticle

Gene Expression
Gene expression
Transcription Factors
Transcription factors
Oligonucleotide Array Sequence Analysis
92 Citations

Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies

Chan, C., Berthiaume, F., Nath, B. D., Tilles, A. W., Toner, M. & Yarmush, M. L. Nov 2004 In : Liver Transplantation. 10, 11, p. 1331-1342 12 p.

Research output: Contribution to journalArticle

Tissue Engineering
Technology
Liver
Equipment and Supplies
Artificial Liver
33 Citations
Blood Stains
Anthralin
Metabolic Networks and Pathways
National Bibliographies
Lutheran Blood-Group System
7 Citations

Insulin concentration during preconditioning mediates the regulation of urea synthesis during exposure to amino acid-supplemented plasma

Li, Z., Yarmush, M. L. & Chan, C. Nov 2004 In : Tissue Engineering. 10, 11-12, p. 1737-1746 10 p.

Research output: Contribution to journalArticle

Insulin
Urea
Amino Acids
Amino acids
Plasmas
21 Citations

Integrating gene expression and metabolic profiles

Li, Z. & Chan, C. Jun 25 2004 In : Journal of Biological Chemistry. 279, 26, p. 27124-27137 14 p.

Research output: Contribution to journalArticle

Metabolome
Transcriptome
Genes
Metabolic Networks and Pathways
Least-Squares Analysis
17 Citations

Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function

Hwang, D., Stephanopoulos, G. & Chan, C. Mar 1 2004 In : Bioinformatics. 20, 4, p. 487-499 13 p.

Research output: Contribution to journalArticle

Environmental factors
Anthralin
Least-Squares Analysis
Multiblock
Library Catalogs
45 Citations
Polyelectrolytes
Magnesium Deficiency
Ethylene Glycol
Acids
Polyethylene glycols
2003
38 Citations

Application of multivariate analysis to optimize function of cultured hepatocytes

Chan, C., Hwang, D., Stephanopoulos, G. N., Yarmush, M. L. & Stephanopoulos, G. Mar 2003 In : Biotechnology Progress. 19, 2, p. 580-598 19 p.

Research output: Contribution to journalArticle

Hepatocytes
Multivariate Analysis
Liver
hepatocytes
liver function
65 Citations

Metabolic Flux Analysis of Cultured Hepatocytes Exposed to Plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L. Jan 5 2003 In : Biotechnology and Bioengineering. 81, 1, p. 33-49 17 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Hepatocytes
Plasmas
Callosities
Insulin
44 Citations

Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma

Chan, C., Berthiaume, F., Lee, K. & Yarmush, M. L. Jan 2003 In : Metabolic Engineering. 5, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Metabolic Flux Analysis
Hepatocytes
Hormones
Amino Acids
Amino acids