Publications 1980 2017

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2017
2 Citations

Calcium-sensing receptor and transient receptor ankyrin-1 mediate emesis induction by deoxynivalenol (vomitoxin)

Wu, W., Zhou, H. R., Bursian, S. J., Link, J. E. & Pestka, J. J. 2017 In : Toxicological Sciences. 155, 1, p. 32-42 11 p.

Research output: Contribution to journalArticle

Ankyrins
Calcium-Sensing Receptors
Vomiting
Mink
Emetics
1 Citations

Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows

Schwartz-Zimmermann, H. E., Hametner, C., Nagl, V., Fiby, I., Macheiner, L., Winkler, J., Dänicke, S., Clark, E., Pestka, J. J. & Berthiller, F. Jun 21 2017 (Accepted/In press) In : Archives of Toxicology. p. 1-16 16 p.

Research output: Contribution to journalArticle

Glucuronides
Metabolites
Rats
Animals
Swine
2 Citations

Sex is a determinant for deoxynivalenol metabolism and elimination in the mouse

Pestka, J. J., Clark, E. S., Schwartz-Zimmermann, H. E. & Berthiller, F. 2017 In : Toxins. 9, 8, 240

Research output: Contribution to journalArticle

Metabolism
Metabolites
Urine
Liver
Kidney
2016
2 Citations

Effects of T-2 toxin on Turkey herpesvirus-induced vaccinal immunity against marek's disease

Kufuor-Mensah, E., Reed, W. M., Sleight, S., Pestka, J., Fadly, A. M. & Dunn, J. R. Mar 1 2016 In : Avian Diseases. 60, 1, p. 56-62 7 p.

Research output: Contribution to journalArticle

Meleagrid Herpesvirus 1
T-2 Toxin
Meleagrid herpesvirus 1
Marek Disease
T-2 toxin
5 Citations

Modeling the emetic potencies of food-borne trichothecenes by benchmark dose methodology

Male, D., Wu, W., Mitchell, N. J., Bursian, S., Pestka, J. J. & Wu, F. Aug 1 2016 In : Food and Chemical Toxicology. 94, p. 178-185 8 p.

Research output: Contribution to journalArticle

Trichothecenes
emetics
Emetics
Benchmarking
trichothecenes
2 Citations

Modelling the anorectic potencies of food-borne trichothecenes by benchmark dose and incremental area under the curve methodology

Male, D., Mitchell, N. J., Wu, W., Bursian, S., Pestka, J. & Wu, F. 2016 In : World Mycotoxin Journal. 9, 2, p. 279-288 10 p.

Research output: Contribution to journalArticle

Trichothecenes
Benchmarking
Appetite Depressants
trichothecenes
deoxynivalenol
2 Citations
Ankyrins
Calcium-Sensing Receptors
Appetite Depressants
Enteroendocrine Cells
Hormones
3 Citations

Production of four macrocyclic trichothecenes by Stachybotrys chartarum during its development on different building materials as measured by UPLC-MS/MS

Aleksic, B., Bailly, S., Draghi, M., Pestka, J. J., Oswald, I. P., Robine, E., Bailly, J. D. & Lacroix, M. Z. Sep 1 2016 In : Building and Environment. 106, p. 265-273 9 p.

Research output: Contribution to journalArticle

toxin
Impurities
Pathology
colonization
pathology

Silica-triggered autoimmunity in lupus-prone mice blocked by docosahexaenoic acid consumption

Bates, M. A., Brandenberger, C., Langohr, I. I., Kumagai, K., Lock, A. L., Harkema, J. R., Holian, A. & Pestka, J. J. Aug 1 2016 In : PLoS One. 11, 8, e0160622

Research output: Contribution to journalArticle

autoimmunity
Docosahexaenoic Acids
docosahexaenoic acid
Autoimmunity
Silicon Dioxide
2015
7 Citations

Comparison of anorectic potencies of the trichothecenes T-2 toxin, HT-2 toxin and satratoxin G to the ipecac alkaloid emetine

Wu, W., Zhou, H. R., Pan, X. & Pestka, J. J. May 1 2015 In : Toxicology Reports. 2, p. 238-251 14 p.

Research output: Contribution to journalArticle

Ipecac
Emetine
T-2 Toxin
Trichothecenes
Appetite Depressants
9 Citations
Enteroendocrine Cells
Ankyrins
Calcium-Sensing Receptors
Glucagon-Like Peptide 1
Cholecystokinin
18 Citations

DON occurrence in grains: A North American perspective

Bianchini, A., Horsley, R., Jack, M. M., Kobielush, B., Ryu, D., Tittlemier, S., Wilson, W. W., Abbas, H. K., Abel, S., Harrison, G., Miller, J. D., Shier, W. T., Weaver, G., Katzke, D., Maier, D. E., Pestka, J., Boroughs, B. & Bridges, A. R. Jan 1 2015 In : Cereal Foods World. 60, 1, p. 32-56 25 p.

Research output: Contribution to journalArticle

deoxynivalenol
North America
Hordeum
supply chain
Triticum
5 Citations

Emetic responses to T-2 toxin, HT-2 toxin and emetine correspond to plasma elevations of peptide YY3–36 and 5-hydroxytryptamine

Wu, W., Zhou, H. R., Bursian, S. J., Link, J. E. & Pestka, J. J. Apr 9 2015 (Accepted/In press) In : Archives of Toxicology.

Research output: Contribution to journalArticle

Emetine
T-2 Toxin
Trichothecenes
Emetics
Vomiting
6 Citations

High sensitivity of aged mice to deoxynivalenol (Vomitoxin)-Induced anorexia corresponds to elevated proinflammatory cytokine and satiety hormone responses

Clark, E. S., Flannery, B. M., Gardner, E. M. & Pestka, J. J. Oct 19 2015 In : Toxins. 7, 10, p. 4199-4215 17 p., A24

Research output: Contribution to journalArticle

Satiety Response
Anorexia
Hormones
Cytokines
Trichothecenes
6 Citations

Murine anorectic response to deoxynivalenol (vomitoxin) is sex-dependent

Clark, E. S., Flannery, B. M. & Pestka, J. J. Jul 29 2015 In : Toxins. 7, 8, p. 2845-2859 15 p.

Research output: Contribution to journalArticle

Appetite Depressants
Trichothecenes
Plasmas
Bioassay
Mycotoxins
9 Citations

Silica triggers inflammation and ectopic lymphoid neogenesis in the lungs in parallel with accelerated onset of systemic autoimmunity and glomerulonephritis in the lupus-prone NZBWF1 mouse

Bates, M. A., Brandenberger, C., Langohr, I., Kumagai, K., Harkema, J. R., Holian, A. & Pestka, J. J. May 15 2015 In : PLoS One. 10, 5, 0125481

Research output: Contribution to journalArticle

glomerulonephritis
Lupus Nephritis
autoimmunity
Autoimmunity
Silicon Dioxide
2014
15 Citations
nephritis
Lupus Nephritis
autoimmunity
T-cells
Omega-3 Fatty Acids
13 Citations

Comparison of anorectic and emetic potencies of deoxynivalenol (vomitoxin) to the plant metabolite deoxynivalenol-3-glucoside and synthetic deoxynivalenol derivatives EN139528 and EN139544

Wu, W., Zhou, H. R., Bursian, S. J., Pan, X., Link, J. E., Berthiller, F., Adam, G., Krantis, A., Durst, T. & Pestka, J. J. Nov 1 2014 In : Toxicological Sciences. 142, 1, p. 167-181 15 p.

Research output: Contribution to journalArticle

Emetics
Appetite Depressants
Metabolites
Derivatives
Vomiting
14 Citations

Direct activation of ribosome-associated double-stranded rna-dependent protein kinase (PKR) by deoxynivalenol, anisomycin and ricin: A new model for ribotoxic stress response induction

Zhou, H. R., He, K., Landgraf, J., Pan, X. & Pestka, J. J. 2014 In : Toxins. 6, 12, p. 3406-3425 20 p., A07

Research output: Contribution to journalArticle

Anisomycin
eIF-2 Kinase
Ricin
Double-Stranded RNA
Ribosomes
13 Citations
Proteome
Ribosomes
Phosphorylation
Proteins
Protein Biosynthesis
22 Citations

Effects of oral exposure to naturally-occurring and synthetic deoxynivalenol congeners on proinflammatory cytokine and chemokine mRNA expression in the mouse.

Wu, W., He, K., Zhou, H. R., Berthiller, F., Adam, G., Sugita-Konishi, Y., Watanabe, M., Krantis, A., Durst, T., Zhang, H. & Pestka, J. J. 2014 In : Toxicology and Applied Pharmacology. 278, 2, p. 107-115 9 p.

Research output: Contribution to journalArticle

Chemokines
Cytokines
Messenger RNA
Up-Regulation
Tumor Necrosis Factor-alpha
17 Citations

Mycotoxins that affect the North American agri-food sector: State of the art and directions for the future

Miller, J. D., Schaafsma, A. W., Bhatnagar, D., Bondy, G., Carbone, I., Harris, L. J., Harrison, G., Munkvold, G. P., Oswald, I. P., Pestka, J. J., Sharpe, L., Sumarah, M. W., Tittlemier, S. A. & Zhou, T. Feb 1 2014 In : World Mycotoxin Journal. 7, 1, p. 63-82 20 p.

Research output: Contribution to journalArticle

Mycotoxins
supply chain
mycotoxins
nutritive value
Food
124 Citations

Public health impacts of foodborne mycotoxins

Wu, F., Groopman, J. D. & Pestka, J. J. 2014 In : Annual review of food science and technology. 5, 1, p. 351-372 22 p.

Research output: Contribution to journalArticle

Mycotoxins
mycotoxins
public health
Public Health
food crops
14 Citations

Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, Fusarenon X, and nivalenol

Wu, W., Zhou, H. R., He, K., Pan, X., Sugita-Konishi, Y., Watanabe, M., Zhang, H. & Pestka, J. J. 2014 In : Toxicological Sciences. 138, 2, p. 278-289 12 p.

Research output: Contribution to journalArticle

Cholecystokinin
Anorexia
Plasmas
Hormones
Trichothecenes
2013
18 Citations

Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages

Solhaug, A., Holme, J. A., Haglund, K., Dendele, B., Sergent, O., Pestka, J., Lagadic-Gossmann, D. & Eriksen, G. S. May 2013 In : Toxicology Letters. 219, 1, p. 8-17 10 p.

Research output: Contribution to journalArticle

Macrophages
Cell Cycle Checkpoints
Cyclin B1
Cells
Cereal products
22 Citations

Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon x, and nivalenol

Wu, W., Bates, M. A., Bursian, S. J., Link, J. E., Flannery, B. M., Sugita-konishi, Y., Watanabe, M., Zhang, H. & Pestka, J. J. Jan 2013 In : Toxicological Sciences. 131, 1, p. 279-291 13 p.

Research output: Contribution to journalArticle

Emetics
Trichothecenes
Vomiting
Animals
Mink
4 Citations

Deoxynivalenol-induced weight loss in the diet-induced obese mouse is reversible and PKR-independent

Flannery, B. M., He, K. & Pestka, J. J. Jul 1 2013 In : Toxicology Letters. 221, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

Reducing Diet
Obese Mice
Nutrition
Diet
Body Weight
15 Citations

Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress

Pan, X., Whitten, D. A., Wu, M., Chan, C., Wilkerson, C. G. & Pestka, J. J. Sep 2013 In : Toxicological Sciences. 135, 1, p. 129-143 15 p.

Research output: Contribution to journalArticle

Spleen
Phosphorylation
Mitogen-Activated Protein Kinases
deoxynivalenol
Phosphatidylinositol 3-Kinase
6 Citations

Evaluation of insulin-like growth factor acid-labile subunit as a potential biomarker of effect for deoxynivalenol-induced proinflammatory cytokine expression

Flannery, B. M., Amuzie, C. J. & Pestka, J. J. Feb 8 2013 In : Toxicology. 304, p. 192-198 7 p.

Research output: Contribution to journalArticle

Biomarkers
Somatomedins
Cytokines
Acids
Plasmas
19 Citations

Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage

Pan, X., Whitten, D. A., Wu, M., Chan, C., Wilkerson, C. G. & Pestka, J. J. Apr 5 2013 In : Toxicology and Applied Pharmacology. 268, 2, p. 201-211 11 p.

Research output: Contribution to journalArticle

Phosphorylation
Macrophages
Proteins
Trichothecenes
Isotope Labeling
7 Citations

Modulation of inflammatory gene expression by the ribotoxin deoxynivalenol involves coordinate regulation of the transcriptome and translatome

He, K., Pan, X., Zhou, H. R. & Pestka, J. J. Jan 2013 In : Toxicological Sciences. 131, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

Transcriptome
Gene expression
Modulation
Gene Expression
Messenger RNA
16 Citations

Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin)

Wu, W., Bates, M. A., Bursian, S. J., Flannery, B., Zhou, H. R., Link, J. E., Zhang, H. & Pestka, J. J. May 2013 In : Toxicological Sciences. 133, 1, p. 186-195 10 p.

Research output: Contribution to journalArticle

Trichothecenes
Vomiting
Serotonin
Granisetron
Cholecystokinin
2012
34 Citations

Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY

Flannery, B. M., Clark, E. S. & Pestka, J. J. Dec 2012 In : Toxicological Sciences. 130, 2, p. 289-297 9 p.

Research output: Contribution to journalArticle

Trichothecenes
Peptide YY
Hormones
Anorexia
Cholecystokinin
22 Citations

Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol

Wu, W., Flannery, B. M., Sugita-Konishi, Y., Watanabe, M., Zhang, H. & Pestka, J. J. Jun 2012 In : Food and Chemical Toxicology. 50, 6, p. 2056-2061 6 p.

Research output: Contribution to journalArticle

fusarenon-X
15-acetyldeoxynivalenol
3-acetyldeoxynivalenol
nivalenol
Appetite Depressants
4 Citations

Impact of environmental factors on growth and satratoxin G production by strains of Stachybotrys chartarum

Frazer, S., Pestka, J., Kim, J., Medina, A., Aldred, D. & Magan, N. Feb 1 2012 In : World Mycotoxin Journal. 5, 1, p. 37-43 7 p.

Research output: Contribution to journalArticle

Stachybotrys chartarum
Stachybotrys
Intercellular Signaling Peptides and Proteins
environmental factors
Growth
12 Citations

Mechanisms for ribotoxin-induced ribosomal RNA cleavage

He, K., Zhou, H. R. & Pestka, J. J. Nov 15 2012 In : Toxicology and Applied Pharmacology. 265, 1, p. 10-18 9 p.

Research output: Contribution to journalArticle

RNA Cleavage
Ribosomal RNA
Anisomycin
Ricin
Chemical activation
28 Citations

Mechanisms involved in alternariol-induced cell cycle arrest

Solhaug, A., Vines, L. L., Ivanova, L., Spilsberg, B., Holme, J. A., Pestkab, J., Collins, A. & Eriksen, G. S. 2012 In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 738-739, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
DNA Damage
Cyclin B
Reactive Oxygen Species
Cell Proliferation
19 Citations
Stachybotrys
Olfactory Receptor Neurons
Rhinitis
Macaca mulatta
Nose
26 Citations

Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage

He, K., Zhou, H. R. & Pestka, J. J. 2012 In : Toxicological Sciences. 127, 2, p. 382-390 9 p.

Research output: Contribution to journalArticle

RNA Cleavage
Ribosomal RNA
Proto-Oncogene Proteins c-hck
Caspase 9
Caspase 8
68 Citations

The role of biomarkers in evaluating human health concerns from fungal contaminants in food

Turner, P. C., Flannery, B., Isitt, C., Ali, M. & Pestka, J. Jun 2012 In : Nutrition Research Reviews. 25, 1, p. 162-179 18 p.

Research output: Contribution to journalArticle

Aflatoxins
Biomarkers
Food
Health
Mycotoxins
2011
15 Citations

ATP mediates neuroprotective and neuroproliferative effects in mouse olfactory epithelium following exposure to satratoxin G in vitro and in vivo

Jia, C., Sangsiri, S., Belock, B., Iqbal, T. R., Pestka, J. J. & Hegg, C. C. Nov 2011 In : Toxicological Sciences. 124, 1, p. 169-178 10 p., kfr213

Research output: Contribution to journalArticle

Olfactory Mucosa
Neuroprotective Agents
Adenosine Triphosphate
Olfactory Receptor Neurons
Apoptosis
13 Citations

Body composition and hormonal effects following exposure to mycotoxin deoxynivalenol in the high-fat diet-induced obese mouse

Kobayashi-Hattori, K., Amuzie, C. J., Flannery, B. M. & Pestka, J. J. Jul 2011 In : Molecular Nutrition and Food Research. 55, 7, p. 1070-1078 9 p.

Research output: Contribution to journalArticle

Obese Mice
Mycotoxins
deoxynivalenol
High Fat Diet
high fat diet
29 Citations

Characterization of deoxynivalenol-induced anorexia using mouse bioassay

Flannery, B. M., Wu, W. & Pestka, J. J. Aug 2011 In : Food and Chemical Toxicology. 49, 8, p. 1863-1869 7 p.

Research output: Contribution to journalArticle

Bioassay
Anorexia
deoxynivalenol
anorexia
Biological Assay
10 Citations

Effects of deoxynivalenol consumption on body weight and adiposity in the diet-induced obese mouse

Amuzie, C. J., Flannery, B. M., Ulrich, A. M. & Pestka, J. J. Jan 2011 In : Journal of Toxicology and Environmental Health - Part A: Current Issues. 74, 10, p. 658-667 10 p.

Research output: Contribution to journalArticle

Obese Mice
Adiposity
Nutrition
Body Weight
Diet
11 Citations

The current state of mycotoxin biomarker development in humans and animals and the potential for application to plant systems

Baldwin, T. T., Riley, R. T., Zitomer, N. C., Voss, K. A., Coulombe, R. A., Pestka, J. J., Williams, D. E. & Glenn, A. E. Aug 1 2011 In : World Mycotoxin Journal. 4, 3, p. 257-270 14 p.

Research output: Contribution to journalArticle

animal development
human development
Mycotoxins
Human Development
Biomarkers
2010
32 Citations

Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity

Maddox, J. F., Amuzie, C. J., Li, M., Newport, S. W., Sparkenbaugh, E., Cuff, C. F., Pestka, J. J., Cantor, G. H., Roth, R. A. & Ganey, P. E. Jan 2010 In : Journal of Toxicology and Environmental Health - Part A: Current Issues. 73, 1, p. 58-73 16 p.

Research output: Contribution to journalArticle

Acetaminophen
Inflammation
Lipopolysaccharides
Liver
Alanine Transaminase
348 Citations

Deoxynivalenol: Mechanisms of action, human exposure, and toxicological relevance

Pestka, J. J. Sep 2010 In : Archives of Toxicology. 84, 9, p. 663-679 17 p.

Research output: Contribution to journalArticle

Toxicology
Trichothecenes
Mycotoxins
Gastroenteritis
Poisoning
66 Citations

Deoxynivalenol-induced proinflammatory gene expression: Mechanisms and pathological sequelae

Pestka, J. J. Jun 2010 In : Toxins. 2, 6, p. 1300-1317 18 p.

Research output: Contribution to journalArticle

Gene expression
Gene Expression
Mycotoxins
Poisons
Chemical activation
19 Citations

DNA damage and DNA damage responses in THP-1 Monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin

Rakkestad, K. E., Skaar, I., Ansteinsson, V. E., Solhaug, A., Holme, J. A., Pestka, J. J., Samuelsen, J. T., Dahlman, H. J., Hongslo, J. K. & Becher, R. May 2010 In : Toxicological Sciences. 115, 1, p. 140-155 16 p.

Research output: Contribution to journalArticle

Stachybotrys
T-2 Toxin
Aspergillus
Spores
DNA Damage
32 Citations

Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes

Bae, H., Gray, J. S., Li, M., Vines, L., Kim, J. & Pestka, J. J. Feb 24 2010 In : Toxicological Sciences. 115, 2, p. 444-452 9 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-hck
Eukaryotic Small Ribosome Subunits
Phagocytes
Phosphorylation
Ribosomes