Sophia Lunt – Publications

2018

Impact of Ultrathin C₆₀ on Perovskite Photovoltaic Devices

Liu, D., Wang, Q., Traverse, C. J., Yang, C., Young, M., Kuttipillai, P. S., Lunt, S. Y., Hamann, T. W. & Lunt, R. R. Jan 23 2018 In : ACS Nano. 12, 1, p. 876-883 8 p.

Research output: Contribution to journal › Article

Fullerenes

Perovskite

fullerenes

solar cells

Photocurrents

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells

Hodeib, M., Ogrodzinski, M. P., Vergnes, L., Reue, K., Karlan, B. Y., Lunt, S. Y. & Aspuria, P. J. P. Jan 1 2018 In : Oncotarget. 9, 3, p. 4044-4060 17 p.

Research output: Contribution to journal › Article

Fallopian Tube Neoplasms

Metabolome

Metformin

Ovarian Neoplasms

Energy Metabolism

2017

Anions for Near-Infrared Selective Organic Salt Photovoltaics

Traverse, C. J., Young, M., Suddard-Bangsund, J., Patrick, T., Bates, M., Chen, P., Wingate, B., Lunt, S. Y., Anctil, A. & Lunt, R. R. Dec 1 2017 In : Scientific Reports. 7, 1, 16399

Research output: Contribution to journal › Article

Anions

Salts

Infrared radiation

Functional groups

Borates

2 Citations

Deciphering metabolic rewiring in breast cancer subtypes

Ogrodzinski, M. P., Bernard, J. J. & Lunt, S. Y. 2017 (Accepted/In press) In : Translational Research.

Research output: Contribution to journal › Article

Metabolism

Cells

Breast Neoplasms

Metabolic Diseases

Survival

1 Citations

Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer

Chakraborty, D., Benham, V., Bullard, B., Kearney, T., Hsia, H. C., Gibbon, D., Demireva, E. Y., Lunt, S. Y. & Bernard, J. J. Nov 30 2017 In : Oncogene. 36, 48, p. 6668-6679 12 p.

Research output: Contribution to journal › Article

Fibroblast Growth Factor Receptors

Intra-Abdominal Fat

Adiposity

Fibroblast Growth Factor 2

Neoplasms

1 Citations

Prediction of years of life after diagnosis of breast cancer using omics and omic-by-treatment interactions

González-Reymúndez, A., de los Campos, G., Gutiérrez, L., Lunt, S. Y. & Vazquez, A. I. Mar 8 2017 (Accepted/In press) In : European Journal of Human Genetics.

Research output: Contribution to journal › Article

Breast Neoplasms

Therapeutics

Neoplasms

Gene Dosage

Survival

2016

9 Citations

Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis

Nault, R., Fader, K. A., Ammendolia, D. A., Dornbos, P., Potter, D., Sharratt, B., Kumagai, K., Harkema, J. R., Lunt, S. Y., Matthews, J. & Zacharewski, T. Dec 1 2016 In : Toxicological sciences : an official journal of the Society of Toxicology. 154, 2, p. 253-266 14 p.

Research output: Contribution to journal › Article

Gene expression

Fibrosis

Metabolism

Gene Expression

Proline

8 Citations

Organic Heptamethine Salts for Photovoltaics and Detectors with Near-Infrared Photoresponse up to 1600 nm

Young, M., Suddard-Bangsund, J., Patrick, T. J., Pajares, N., Traverse, C. J., Barr, M. C., Lunt, S. Y. & Lunt, R. R. 2016 (Accepted/In press) In : Advanced Optical Materials.

Research output: Contribution to journal › Article

Salts

salts

Infrared radiation

Detectors

detectors

13 Citations

Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

Nault, R., Fader, K. A., Kirby, M. P., Ahmed, S., Matthews, J., Jones, A. D., Lunt, S. Y. & Zacharewski, T. R. Feb 1 2016 In : Toxicological Sciences. 149, 2, p. 358-371 14 p., kfv245

Research output: Contribution to journal › Article

Pyruvate Kinase

Aryl Hydrocarbon Receptors

Protein Isoforms

Impurities

NADP

2015

115 Citations

A roadmap for interpreting ¹³C metabolite labeling patterns from cells

Buescher, J. M. , Antoniewicz, M. R. , Boros, L. G. , Burgess, S. C. , Brunengraber, H. , Clish, C. B. , DeBerardinis, R. J. , Feron, O. , Frezza, C. , Ghesquiere, B. , Gottlieb, E. , Hiller, K. , Jones, R. G. , Kamphorst, J. J. , Kibbey, R. G. , Kimmelman, A. C. , Locasale, J. W. , Lunt, S. Y. , Maddocks, O. D. K. , Malloy, C. & 17 others Metallo, C. M., Meuillet, E. J., Munger, J., Nöh, K., Rabinowitz, J. D., Ralser, M., Sauer, U., Stephanopoulos, G., St-Pierre, J., Tennant, D. A., Wittmann, C., Vander Heiden, M. G., Vazquez, A., Vousden, K., Young, J. D., Zamboni, N. & Fendt, S. M. Aug 1 2015 In : Current Opinion in Biotechnology. 34, p. 189-201 13 p.

Research output: Contribution to journal › Article

Data integration

Metabolites

Metabolism

Labeling

Nutrients

4 Citations

Erratum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells (Nature (2015) 520 (192-197) DOI:10.1038/nature14362)

Schoors, S. , Bruning, U. , Missiaen, R. , Queiroz, K. C. S. , Borgers, G. , Elia, I. , Zecchin, A. , Cantelmo, A. R. , Christen, S. , Goveia, J. , Heggermont, W. , Goddë, L. , Vinckier, S. , Van Veldhoven, P. P. , Eelen, G. , Schoonjans, L. , Gerhardt, H. , Dewerchin, M. , Baes, M. , De Bock, K. & 4 others Ghesquière, B., Lunt, S. Y., Fendt, S. M. & Carmeliet, P. Oct 1 2015 In : Nature. 526, 7571, p. 144 1 p.

Research output: Contribution to journal › Article

108 Citations

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Schoors, S. , Bruning, U. , Missiaen, R. , Queiroz, K. C. S. , Borgers, G. , Elia, I. , Zecchin, A. , Cantelmo, A. R. , Christen, S. , Goveia, J. , Heggermont, W. , Goddé, L. , Vinckier, S. , Van Veldhoven, P. P. , Eelen, G. , Schoonjans, L. , Gerhardt, H. , Dewerchin, M. , Baes, M. , De Bock, K. & 4 others Ghesquière, B., Lunt, S. Y., Fendt, S. M. & Carmeliet, P. Apr 9 2015 In : Nature. 520, 7546, p. 192-197 6 p.

Research output: Contribution to journal › Article

Fatty Acids

Carbon

Endothelial Cells

Acetyl Coenzyme A

Aspartic Acid

63 Citations

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

Lunt, S. Y. , Muralidhar, V. , Hosios, A. M. , Israelsen, W. J. , Gui, D. Y. , Newhouse, L. , Ogrodzinski, M. , Hecht, V. , Xu, K. , Acevedo, P. N. M. , Hollern, D. P. , Bellinger, G. , Dayton, T. L. , Christen, S. , Elia, I. , Dinh, A. T. , Stephanopoulos, G. , Manalis, S. R. , Yaffe, M. B. , Andrechek, E. R. & 2 others Fendt, S. M. & Vander Heiden, M. G. Jan 8 2015 In : Molecular Cell. 57, 1, p. 95-107 13 p.

Research output: Contribution to journal › Article

Pyruvate Kinase

Protein Isoforms

Nucleotides

Cell Proliferation

Thymine

2014

34 Citations

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

Aspuria, P. J. P., Lunt, S. Y., Väremo, L., Vergnes, L., Gozo, M., Beach, J. A., Salumbides, B., Reue, K., Wiedemeyer, W. R., Nielsen, J., Karlan, B. Y. & Orsulic, S. Dec 15 2014 In : Cancer and Metabolism. 2, 1, 21

Research output: Contribution to journal › Article

Epithelial-Mesenchymal Transition

Succinate Dehydrogenase

Epigenomics

Ovarian Neoplasms

Carbon

2013

20 Citations

Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation

Martin, E. S. , Belmont, P. J. , Sinnamon, M. J. , Richard, L. G. , Yuan, J. , Coffee, E. M. , Roper, J. , Lee, L. , Heidari, P. , Lunt, S. Y. , Goel, G. , Ji, X. , Xie, Z. , Xie, T. , Lamb, J. , Weinrich, S. L. , VanArsdale, T. , Bronson, R. T. , Xavier, R. J. , Vander Heiden, M. G. & 3 others Kan, J. L. C., Mahmood, U. & Hung, K. E. Jun 1 2013 In : Clinical Cancer Research. 19, 11, p. 2929-2940 12 p.

Research output: Contribution to journal › Article

Drug Discovery

Colonic Neoplasms

Colorectal Neoplasms

Transplants

Cell Line

2012

3 Citations

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (Nature Chemical Biology (2012) 8 (839-847))

Anastasiou, D. , Yu, Y. , Israelsen, W. J. , Jiang, J. K. , Boxer, M. B. , Hong, B. S. , Tempel, W. , Dimov, S. , Shen, M. , Jha, A. , Yang, H. , Mattaini, K. R. , Metallo, C. M. , Fiske, B. P. , Courtney, K. D. , Malstrom, S. , Khan, T. M. , Kung, C. , Skoumbourdis, A. P. , Veith, H. & 23 others Southall, N., Walsh, M. J., Brimacombe, K. R., Leister, W., Lunt, S. Y., Johnson, Z. R., Yen, K. E., Kunii, K., Davidson, S. M., Christofk, H. R., Austin, C. P., Inglese, J., Harris, M. H., Asara, J. M., Stephanopoulos, G., Salituro, F. G., Jin, S., Dang, L., Auld, D. S., Park, H. W., Cantley, L. C., Thomas, C. J. & Vander Heiden, M. G. Dec 2012 In : Nature Chemical Biology. 8, 12, p. 1008 1 p.

Research output: Contribution to journal › Article

243 Citations

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Anastasiou, D. , Yu, Y. , Israelsen, W. J. , Jiang, J. K. , Boxer, M. B. , Hong, B. S. , Tempel, W. , Dimov, S. , Shen, M. , Jha, A. , Yang, H. , Mattaini, K. R. , Metallo, C. M. , Fiske, B. P. , Courtney, K. D. , Malstrom, S. , Khan, T. M. , Kung, C. , Skoumbourdis, A. P. , Veith, H. & 23 others Southall, N., Walsh, M. J., Brimacombe, K. R., Leister, W., Lunt, S. Y., Johnson, Z. R., Yen, K. E., Kunii, K., Davidson, S. M., Christofk, H. R., Austin, C. P., Inglese, J., Harris, M. H., Asara, J. M., Stephanopoulos, G., Salituro, F. G., Jin, S., Dang, L., Auld, D. S., Park, H. W., Cantley, L. C., Thomas, C. J. & Vander Heiden, M. G. 2012 In : Nature Chemical Biology. 8, 10, p. 839-847 9 p.

Research output: Contribution to journal › Article

Pyruvate Kinase

Carcinogenesis

Neoplasms

Cell Proliferation

Phosphotyrosine

2011

722 Citations

Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation

Lunt, S. Y. & Vander Heiden, M. G. 2011 In : Annual Review of Cell and Developmental Biology. 27, p. 441-464 24 p.

Research output: Contribution to journal › Article

Glycolysis

Cell Proliferation

Neoplasms

Biomass

Respiration

124 Citations

Metabolic pathway alterations that support: Cell Proliferation

Heiden Vander, M. G., Lunt, S. Y., Dayton, T. L., Fiske, B. P., Israelsen, W. J., Mattaini, K. R., Vokes, N. I., Stephanopoulos, G., Cantley, L. C., Metallo, C. M. & Locasale, J. W. 2011 In : Cold Spring Harbor Symposia on Quantitative Biology. 76, p. 325-334 10 p.

Research output: Contribution to journal › Article

Cell proliferation

Metabolic Networks and Pathways

Metabolism

Cell Proliferation

Phosphoenolpyruvate