Publications 2011 2017

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  • 13 Article
  • 1 Comment/debate
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Article
2017

Deciphering metabolic rewiring in breast cancer subtypes

Ogrodzinski, M. P., Bernard, J. J. & Lunt, S. Y. 2017 In : Translational Research.

Research output: Contribution to journalArticle

Supravalvular Aortic Stenosis
Castration
Metabolism
Breast Neoplasms
Metabolic Diseases
1 Citations
Breast Neoplasms
Neoplasms
Gene Dosage
Medical Genetics
Cause of Death
2016
2 Citations

Organic Heptamethine Salts for Photovoltaics and Detectors with Near-Infrared Photoresponse up to 1600 nm

Young, M., Suddard-Bangsund, J., Patrick, T. J., Pajares, N., Traverse, C. J., Barr, M. C., Lunt, S. Y. & Lunt, R. R. 2016 In : Advanced Optical Materials.

Research output: Contribution to journalArticle

Salts
Infrared radiation
Detectors
9 Citations

Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

Nault, R., Fader, K. A., Kirby, M. P., Ahmed, S., Matthews, J., Jones, A. D., Lunt, S. Y. & Zacharewski, T. R. Feb 1 2016 In : Toxicological Sciences. 149, 2, p. 358-371 14 p., kfv245

Research output: Contribution to journalArticle

Tetrachlorodibenzodioxin
Pyruvate Kinase
Dioxins
Protein Isoforms
Liver
2015
93 Citations

A roadmap for interpreting 13C metabolite labeling patterns from cells

Buescher, J. M. , Antoniewicz, M. R. , Boros, L. G. , Burgess, S. C. , Brunengraber, H. , Clish, C. B. , DeBerardinis, R. J. , Feron, O. , Frezza, C. , Ghesquiere, B. , Gottlieb, E. , Hiller, K. , Jones, R. G. , Kamphorst, J. J. , Kibbey, R. G. , Kimmelman, A. C. , Locasale, J. W. , Lunt, S. Y. , Maddocks, O. D. K. , Malloy, C. & 17 others Metallo, C. M., Meuillet, E. J., Munger, J., Nöh, K., Rabinowitz, J. D., Ralser, M., Sauer, U., Stephanopoulos, G., St-Pierre, J., Tennant, D. A., Wittmann, C., Vander Heiden, M. G., Vazquez, A., Vousden, K., Young, J. D., Zamboni, N. & Fendt, S. M. Aug 1 2015 In : Current Opinion in Biotechnology. 34, p. 189-201 13 p.

Research output: Contribution to journalArticle

MSH Release-Inhibiting Hormone
Mastication
Metabolites
Labeling
Biomedical Research
2 Citations

Erratum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells (Nature (2015) 520 (192-197) DOI:10.1038/nature14362)

Schoors, S. , Bruning, U. , Missiaen, R. , Queiroz, K. C. S. , Borgers, G. , Elia, I. , Zecchin, A. , Cantelmo, A. R. , Christen, S. , Goveia, J. , Heggermont, W. , Goddë, L. , Vinckier, S. , Van Veldhoven, P. P. , Eelen, G. , Schoonjans, L. , Gerhardt, H. , Dewerchin, M. , Baes, M. , De Bock, K. & 4 others Ghesquière, B., Lunt, S. Y., Fendt, S. M. & Carmeliet, P. Oct 1 2015 In : Nature. 526, 7571, p. 144 1 p.

Research output: Contribution to journalArticle

87 Citations

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Schoors, S. , Bruning, U. , Missiaen, R. , Queiroz, K. C. S. , Borgers, G. , Elia, I. , Zecchin, A. , Cantelmo, A. R. , Christen, S. , Goveia, J. , Heggermont, W. , Goddé, L. , Vinckier, S. , Van Veldhoven, P. P. , Eelen, G. , Schoonjans, L. , Gerhardt, H. , Dewerchin, M. , Baes, M. , De Bock, K. & 4 others Ghesquière, B., Lunt, S. Y., Fendt, S. M. & Carmeliet, P. Apr 9 2015 In : Nature. 520, 7546, p. 192-197 6 p.

Research output: Contribution to journalArticle

Fatty Acids
Carbon
Endothelial Cells
Acetyl Coenzyme A
Aspartic Acid
52 Citations

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

Lunt, S. Y. , Muralidhar, V. , Hosios, A. M. , Israelsen, W. J. , Gui, D. Y. , Newhouse, L. , Ogrodzinski, M. , Hecht, V. , Xu, K. , Acevedo, P. N. M. , Hollern, D. P. , Bellinger, G. , Dayton, T. L. , Christen, S. , Elia, I. , Dinh, A. T. , Stephanopoulos, G. , Manalis, S. R. , Yaffe, M. B. , Andrechek, E. R. & 2 others Fendt, S. M. & Vander Heiden, M. G. Jan 8 2015 In : Molecular Cell. 57, 1, p. 95-107 13 p.

Research output: Contribution to journalArticle

Pyruvate Kinase
Protein Isoforms
Nucleotides
Cell Proliferation
DNA
2013
18 Citations

Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation

Martin, E. S. , Belmont, P. J. , Sinnamon, M. J. , Richard, L. G. , Yuan, J. , Coffee, E. M. , Roper, J. , Lee, L. , Heidari, P. , Lunt, S. Y. , Goel, G. , Ji, X. , Xie, Z. , Xie, T. , Lamb, J. , Weinrich, S. L. , VanArsdale, T. , Bronson, R. T. , Xavier, R. J. , Vander Heiden, M. G. & 3 others Kan, J. L. C., Mahmood, U. & Hung, K. E. Jun 1 2013 In : Clinical Cancer Research. 19, 11, p. 2929-2940 12 p.

Research output: Contribution to journalArticle

Drug Discovery
Colonic Neoplasms
Colorectal Neoplasms
Transplants
Cell Line
2012
3 Citations

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (Nature Chemical Biology (2012) 8 (839-847))

Anastasiou, D. , Yu, Y. , Israelsen, W. J. , Jiang, J. K. , Boxer, M. B. , Hong, B. S. , Tempel, W. , Dimov, S. , Shen, M. , Jha, A. , Yang, H. , Mattaini, K. R. , Metallo, C. M. , Fiske, B. P. , Courtney, K. D. , Malstrom, S. , Khan, T. M. , Kung, C. , Skoumbourdis, A. P. , Veith, H. & 23 others Southall, N., Walsh, M. J., Brimacombe, K. R., Leister, W., Lunt, S. Y., Johnson, Z. R., Yen, K. E., Kunii, K., Davidson, S. M., Christofk, H. R., Austin, C. P., Inglese, J., Harris, M. H., Asara, J. M., Stephanopoulos, G., Salituro, F. G., Jin, S., Dang, L., Auld, D. S., Park, H. W., Cantley, L. C., Thomas, C. J. & Vander Heiden, M. G. Dec 2012 In : Nature Chemical Biology. 8, 12, p. 1008 1 p.

Research output: Contribution to journalArticle

220 Citations

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Anastasiou, D. , Yu, Y. , Israelsen, W. J. , Jiang, J. K. , Boxer, M. B. , Hong, B. S. , Tempel, W. , Dimov, S. , Shen, M. , Jha, A. , Yang, H. , Mattaini, K. R. , Metallo, C. M. , Fiske, B. P. , Courtney, K. D. , Malstrom, S. , Khan, T. M. , Kung, C. , Skoumbourdis, A. P. , Veith, H. & 23 others Southall, N., Walsh, M. J., Brimacombe, K. R., Leister, W., Lunt, S. Y., Johnson, Z. R., Yen, K. E., Kunii, K., Davidson, S. M., Christofk, H. R., Austin, C. P., Inglese, J., Harris, M. H., Asara, J. M., Stephanopoulos, G., Salituro, F. G., Jin, S., Dang, L., Auld, D. S., Park, H. W., Cantley, L. C., Thomas, C. J. & Vander Heiden, M. G. 2012 In : Nature Chemical Biology. 8, 10, p. 839-847 9 p.

Research output: Contribution to journalArticle

Pyruvate Kinase
Carcinogenesis
Neoplasms
Fructose
Cell Proliferation
2011
628 Citations

Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation

Lunt, S. Y. & Vander Heiden, M. G. 2011 In : Annual Review of Cell and Developmental Biology. 27, p. 441-464 24 p.

Research output: Contribution to journalArticle

Glycolysis
Cell Proliferation
Neoplasms
Biomass
Respiration
110 Citations

Metabolic pathway alterations that support: Cell Proliferation

Heiden Vander, M. G., Lunt, S. Y., Dayton, T. L., Fiske, B. P., Israelsen, W. J., Mattaini, K. R., Vokes, N. I., Stephanopoulos, G., Cantley, L. C., Metallo, C. M. & Locasale, J. W. 2011 In : Cold Spring Harbor Symposia on Quantitative Biology. 76, p. 325-334 10 p.

Research output: Contribution to journalArticle

Metabolic Networks and Pathways
Cell Proliferation
Metabolism
Panthera
Cerebellar Ataxia