Publications 2005 2015

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2015
8 Citations

Adaptive posttranslational control in cellular stress response pathways and its relationship to toxicity testing and safety assessment

Zhang, Q., Bhattacharya, S., Pi, J., Clewell, R. A., Carmichael, P. L. & Andersen, M. E. Oct 1 2015 In : Toxicological Sciences. 147, 2, p. 302-316 15 p., kfv130

Research output: Contribution to journalArticle

Safety
Genes
Addison Disease
Blood Flow Velocity
Heat-Shock Proteins
29 Citations

Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses

Zhang, Q., Bhattacharya, S., Conolly, R. B., Clewell, H. J., Kaminski, N. E. & Andersen, M. E. 2015 In : Environmental Health Perspectives. 122, 12, p. 1261-1270 10 p.

Research output: Contribution to journalArticle

In Vitro Techniques
Biological Models
Homeostasis
Apoptosis
Health
2014
35 Citations

A map of the PPARα transcription regulatory network for primary human hepatocytes

McMullen, P. D., Bhattacharya, S., Woods, C. G., Sun, B., Yarborough, K., Ross, S. M., Miller, M. E., McBride, M. T., Lecluyse, E. L., Clewell, R. A. & Andersen, M. E. Feb 25 2014 In : Chemico-Biological Interactions. 209, 1, p. 14-24 11 p.

Research output: Contribution to journalArticle

Hepatocytes
Transcription Factors
Gene Expression
Genes
Cyclic AMP Receptor Protein
2013
8 Citations

All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

Zhang, Q., Kline, D. E., Bhattacharya, S., Crawford, R. B., Conolly, R. B., Thomas, R. S., Andersen, M. E. & Kaminski, N. E. Apr 1 2013 In : Toxicology and Applied Pharmacology. 268, 1, p. 17-26 10 p.

Research output: Contribution to journalArticle

Tetrachlorodibenzodioxin
Cell Differentiation
B-Lymphocytes
Castration
Aryl Hydrocarbon Receptors
341 Citations

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P. , Hewitt, N. J. , Albrecht, U. , Andersen, M. E. , Ansari, N. , Bhattacharya, S. , Bode, J. G. , Bolleyn, J. , Borner, C. , Böttger, J. , Braeuning, A. , Budinsky, R. A. , Burkhardt, B. , Cameron, N. R. , Camussi, G. , Cho, C. S. , Choi, Y. J. , Craig Rowlands, J. , Dahmen, U. , Damm, G. & 73 others Dirsch, O., Donato, M. T., Dong, J., Dooley, S., Drasdo, D., Eakins, R., Ferreira, K. S., Fonsato, V., Fraczek, J., Gebhardt, R., Gibson, A., Glanemann, M., Goldring, C. E. P., Gómez-Lechón, M. J., Groothuis, G. M. M., Gustavsson, L., Guyot, C., Hallifax, D., Hammad, S., Hayward, A., Häussinger, D., Hellerbrand, C., Hewitt, P., Hoehme, S., Holzhütter, H. G., Houston, J. B., Hrach, J., Ito, K., Jaeschke, H., Keitel, V., Kelm, J. M., Kevin Park, B., Kordes, C., Kullak-Ublick, G. A., Lecluyse, E. L., Lu, P., Luebke-Wheeler, J., Lutz, A., Maltman, D. J., Matz-Soja, M., McMullen, P., Merfort, I., Messner, S., Meyer, C., Mwinyi, J., Naisbitt, D. J., Nussler, A. K., Olinga, P., Pampaloni, F., Pi, J., Pluta, L., Przyborski, S. A., Ramachandran, A., Rogiers, V., Rowe, C., Schelcher, C., Schmich, K., Schwarz, M., Singh, B., Stelzer, E. H. K., Stieger, B., Stöber, R., Sugiyama, Y., Tetta, C., Thasler, W. E., Vanhaecke, T., Vinken, M., Weiss, T. S., Widera, A., Woods, C. G., Xu, J. J., Yarborough, K. M. & Hengstler, J. G. Aug 2013 In : Archives of Toxicology. 87, 8, p. 1315-1530 216 p.

Research output: Contribution to journalArticle

Hepatocytes
Liver
In Vitro Techniques
Fibrin
Metabolism
7 Citations

Toxicogenomics for transcription factor-governed molecular pathways: Moving on to roles beyond classification and prediction

Andersen, M. E., McMullen, P. D. & Bhattacharya, S. Jan 2013 In : Archives of Toxicology. 87, 1, p. 7-11 5 p.

Research output: Contribution to journalArticle

Toxicogenetics
Transcription Factors
63 Citations

Ultrasensitive response motifs: Basic amplifiers in molecular signalling networks

Zhang, Q., Bhattacharya, S. & Andersen, M. E. 2013 In : Open Biology. 3, APR, 130031

Research output: Contribution to journalArticle

Nonlinear Dynamics
Gene Regulatory Networks
Sigmoid Colon
Signal Transduction
Homeostasis
2012
26 Citations

Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches

Bhattacharya, S., Shoda, L. K. M., Zhang, Q., Woods, C. G., Howell, B. A., Siler, S. Q., Woodhead, J. L., Yang, Y., McMullen, P., Watkins, P. B. & Melvin, E. A. 2012 In : Frontiers in Physiology. 3 DEC, Article 462

Research output: Contribution to journalArticle

Systems Biology
Drug Design
Liver
Drug-Induced Liver Injury
Chemical Safety
2011
48 Citations

A deterministic map of Waddington's epigenetic landscape for cell fate specification

Bhattacharya, S., Zhang, Q. & Andersen, M. E. May 27 2011 In : BMC Systems Biology. 5, 85

Research output: Contribution to journalArticle

Epigenomics
Cell
Genes
Gene Regulatory Networks
Cell Lineage
101 Citations

Toxicity testing in the 21st century: Defining new risk assessment approaches based on perturbation of intracellular toxicity pathways

Bhattacharya, S., Zhang, Q., Carmichael, P. L., Boekelheide, K. & Andersen, M. E. 2011 In : PLoS One. 6, 6, e20887

Research output: Contribution to journalArticle

Acrodermatitis
Research Report
toxicity
Blood Stains
European Union
2010
22 Citations

A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Bhattacharya, S., Conolly, R. B., Kaminski, N. E., Thomas, R. S., Andersen, M. E. & Zhang, Q. May 2010 In : Toxicological Sciences. 115, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

Tetrachlorodibenzodioxin
Cell Differentiation
B-Lymphocytes
Castration
Callosities
34 Citations

Computational systems biology and dose-response modeling in relation to new directions in toxicity testing

Zhang, Q., Bhattacharya, S., Andersen, M. E. & Conolly, R. B. Feb 2010 In : Journal of Toxicology and Environmental Health - Part B: Critical Reviews. 13, 2-4, p. 253-276 24 p.

Research output: Contribution to journalArticle

Systems Biology
Biological Science Disciplines
Computational Biology
Computer Simulation
Acrodermatitis
15 Citations

Stochastic modeling of b lymphocyte terminal differentiation and its suppression by dioxin

Zhang, Q., Bhattacharya, S., Kline, D. E., Crawford, R. B., Conolly, R. B., Thomas, R. S., Kaminski, N. E. & Andersen, M. E. Apr 1 2010 In : BMC Systems Biology. 4, 40

Research output: Contribution to journalArticle

B cells
Dioxins
B-Lymphocytes
Lymphocytes
Cells
2008
21 Citations
Erythrasma
Silica
gels
silicon dioxide
Nerve Crush
2005
22 Citations

Fractal dimensions of silica gels generated using reactive molecular dynamics simulations

Bhattacharya, S. & Kieffer, J. 2005 In : Journal of Chemical Physics. 122, 9, 094715

Research output: Contribution to journalArticle

fractals
Iduronate Sulfatase
gels
silicon dioxide
Alveoloplasty