Publications 2005 2015

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2015
8 Citations

Adaptive posttranslational control in cellular stress response pathways and its relationship to toxicity testing and safety assessment

Zhang, Q., Bhattacharya, S., Pi, J., Clewell, R. A., Carmichael, P. L. & Andersen, M. E. Oct 1 2015 In : Toxicological Sciences. 147, 2, p. 302-316 15 p., kfv130

Research output: Research - peer-reviewArticle

Safety
Genes
Toxicity
Testing
Heat-Shock Proteins
29 Citations

Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses

Zhang, Q., Bhattacharya, S., Conolly, R. B., Clewell, H. J., Kaminski, N. E. & Andersen, M. E. 2015 In : Environmental Health Perspectives. 122, 12, p. 1261-1270 10 p.

Research output: Research - peer-reviewArticle

In Vitro Techniques
Biological Models
Homeostasis
Apoptosis
Health
2014
36 Citations

A map of the PPARα transcription regulatory network for primary human hepatocytes

McMullen, P. D., Bhattacharya, S., Woods, C. G., Sun, B., Yarborough, K., Ross, S. M., Miller, M. E., McBride, M. T., Lecluyse, E. L., Clewell, R. A. & Andersen, M. E. Feb 25 2014 In : Chemico-Biological Interactions. 209, 1, p. 14-24 11 p.

Research output: Research - peer-reviewArticle

Hepatocytes
Transcription Factors
Gene Expression
Genes
GW 7647
2013
10 Citations

All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

Zhang, Q., Kline, D. E., Bhattacharya, S., Crawford, R. B., Conolly, R. B., Thomas, R. S., Andersen, M. E. & Kaminski, N. E. Apr 1 2013 In : Toxicology and Applied Pharmacology. 268, 1, p. 17-26 10 p.

Research output: Research - peer-reviewArticle

Cells
Impurities
1,4-dioxin
Cell Differentiation
B-Lymphocytes
349 Citations

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P. , Hewitt, N. J. , Albrecht, U. , Andersen, M. E. , Ansari, N. , Bhattacharya, S. , Bode, J. G. , Bolleyn, J. , Borner, C. , Böttger, J. , Braeuning, A. , Budinsky, R. A. , Burkhardt, B. , Cameron, N. R. , Camussi, G. , Cho, C. S. , Choi, Y. J. , Craig Rowlands, J. , Dahmen, U. , Damm, G. & 73 others Dirsch, O., Donato, M. T., Dong, J., Dooley, S., Drasdo, D., Eakins, R., Ferreira, K. S., Fonsato, V., Fraczek, J., Gebhardt, R., Gibson, A., Glanemann, M., Goldring, C. E. P., Gómez-Lechón, M. J., Groothuis, G. M. M., Gustavsson, L., Guyot, C., Hallifax, D., Hammad, S., Hayward, A., Häussinger, D., Hellerbrand, C., Hewitt, P., Hoehme, S., Holzhütter, H. G., Houston, J. B., Hrach, J., Ito, K., Jaeschke, H., Keitel, V., Kelm, J. M., Kevin Park, B., Kordes, C., Kullak-Ublick, G. A., Lecluyse, E. L., Lu, P., Luebke-Wheeler, J., Lutz, A., Maltman, D. J., Matz-Soja, M., McMullen, P., Merfort, I., Messner, S., Meyer, C., Mwinyi, J., Naisbitt, D. J., Nussler, A. K., Olinga, P., Pampaloni, F., Pi, J., Pluta, L., Przyborski, S. A., Ramachandran, A., Rogiers, V., Rowe, C., Schelcher, C., Schmich, K., Schwarz, M., Singh, B., Stelzer, E. H. K., Stieger, B., Stöber, R., Sugiyama, Y., Tetta, C., Thasler, W. E., Vanhaecke, T., Vinken, M., Weiss, T. S., Widera, A., Woods, C. G., Xu, J. J., Yarborough, K. M. & Hengstler, J. G. Aug 2013 In : Archives of Toxicology. 87, 8, p. 1315-1530 216 p.

Research output: Research - peer-reviewArticle

Hepatocytes
Liver
In Vitro Techniques
Cell signaling
Metabolism
7 Citations

Toxicogenomics for transcription factor-governed molecular pathways: Moving on to roles beyond classification and prediction

Andersen, M. E., McMullen, P. D. & Bhattacharya, S. Jan 2013 In : Archives of Toxicology. 87, 1, p. 7-11 5 p.

Research output: Research - peer-reviewArticle

63 Citations

Ultrasensitive response motifs: Basic amplifiers in molecular signalling networks

Zhang, Q., Bhattacharya, S. & Andersen, M. E. 2013 In : Open Biology. 3, APR, 130031

Research output: Research - peer-reviewArticle

Nonlinear Dynamics
Gene Regulatory Networks
Sigmoid Colon
Periodicity
Signal Transduction
2012
26 Citations

Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches

Bhattacharya, S., Shoda, L. K. M., Zhang, Q., Woods, C. G., Howell, B. A., Siler, S. Q., Woodhead, J. L., Yang, Y., McMullen, P., Watkins, P. B. & Melvin, E. A. 2012 In : Frontiers in Physiology. 3 DEC, Article 462

Research output: Research - peer-reviewArticle

Systems Biology
Drug Design
Liver
Pharmaceutical Preparations
Chemical and Drug Induced Liver Injury
2011
48 Citations

A deterministic map of Waddington's epigenetic landscape for cell fate specification

Bhattacharya, S., Zhang, Q. & Andersen, M. E. May 27 2011 In : BMC Systems Biology. 5, 85

Research output: Research - peer-reviewArticle

Specification
Cell
Epigenomics
Genes
Specifications
102 Citations

Toxicity testing in the 21st century: Defining new risk assessment approaches based on perturbation of intracellular toxicity pathways

Bhattacharya, S., Zhang, Q., Carmichael, P. L., Boekelheide, K. & Andersen, M. E. 2011 In : PLoS One. 6, 6, e20887

Research output: Research - peer-reviewArticle

risk assessment process
toxicity testing
toxicity
Risk assessment
Toxicity
2010
23 Citations

A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Bhattacharya, S., Conolly, R. B., Kaminski, N. E., Thomas, R. S., Andersen, M. E. & Zhang, Q. May 2010 In : Toxicological Sciences. 115, 1, p. 51-65 15 p.

Research output: Research - peer-reviewArticle

Cells
Switches
Impurities
1,4-dioxin
Cell Differentiation
34 Citations

Computational systems biology and dose-response modeling in relation to new directions in toxicity testing

Zhang, Q., Bhattacharya, S., Andersen, M. E. & Conolly, R. B. Feb 2010 In : Journal of Toxicology and Environmental Health - Part B: Critical Reviews. 13, 2-4, p. 253-276 24 p.

Research output: Research - peer-reviewArticle

Systems Biology
Biological Science Disciplines
Computational Biology
Computer Simulation
Direction compound
15 Citations

Stochastic modeling of b lymphocyte terminal differentiation and its suppression by dioxin

Zhang, Q., Bhattacharya, S., Kline, D. E., Crawford, R. B., Conolly, R. B., Thomas, R. S., Kaminski, N. E. & Andersen, M. E. Apr 1 2010 In : BMC Systems Biology. 4, 40

Research output: Research - peer-reviewArticle

Stochastic Modeling
B Cells
Lymphocytes
Dioxins
B-Lymphocytes
2008
21 Citations
Silicic Acid
Polycondensation
Silicon Dioxide
Molecular dynamics
Gels
2005
23 Citations

Fractal dimensions of silica gels generated using reactive molecular dynamics simulations

Bhattacharya, S. & Kieffer, J. 2005 In : Journal of Chemical Physics. 122, 9, 094715

Research output: Research - peer-reviewArticle

Silica Gel
Fractal dimension
Silicon Dioxide
Molecular dynamics
Computer simulation