Profile The profile is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Androgen Receptor Antagonists Medicine & Life Sciences
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Grants 2013 2017

Publications 2001 2017

  • 4 h-Index
  • 7 Article
1 Citations

5-HT causes splanchnic venodilation

Seitz, B. M., Orer, H. S., Krieger-Burke, T., Darios, E. S., Thompson, J. M., Fink, G. D. & Watts, S. W. Sep 12 2017 In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 3, p. H676-H686

Research output: Contribution to journalArticle

Blood Pressure
Inferior Vena Cava
Portal Vein
3 Citations
Mesenteric Veins
Abdominal Aorta
Inferior Vena Cava
408 Citations

Physiochemical drug properties associated with in vivo toxicological outcomes

Hughes, J. D., Blagg, J., Price, D. A., Bailey, S., DeCrescenzo, G. A., Devraj, R. V., Ellsworth, E., Fobian, Y. M., Gibbs, M. E., Gilles, R. W., Greene, N., Huang, E., Krieger-Burke, T., Loesel, J., Wager, T., Whiteley, L. & Zhang, Y. Sep 1 2008 In : Bioorganic and Medicinal Chemistry Letters. 18, 17, p. 4872-4875 4 p.

Research output: Contribution to journalArticle

Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
3 Citations

Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)- 2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications

Jie, J. L. , Iula, D. M. , Nguyen, M. N. , Hu, L. Y. , Dettling, D. , Johnson, T. R. , Du, D. Y. , Shanmugasundaram, V. , Van Camp, J. A. , Wang, Z. , Harter, W. G. , Yue, W. S. , Boys, M. L. , Wade, K. J. , Drummond, E. M. , Samas, B. M. , Lefker, B. A. , Hoge, G. S. , Lovdahl, M. J. , Asbill, J. & 4 others Carroll, M., Meade, M. A., Ciotti, S. M. & Krieger-Burke, T. Nov 13 2008 In : Journal of Medicinal Chemistry. 51, 21, p. 7010-7014 5 p.

Research output: Contribution to journalArticle

Androgen Receptor Antagonists
Phototoxic Dermatitis
9 Citations

(1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production

Hu, L. Y. , Du, D. , Hoffman, J. , Smith, Y. , Fedij, V. , Kostlan, C. , Johnson, T. R. , Huang, Y. , Kesten, S. , Harter, W. , Yue, W. S. , Li, J. J. , Barvian, N. , Mitchell, L. , Lei, H. J. , Lefker, B. , Carroll, M. , Dettling, D. , Krieger-Burke, T. , Samas, B. & 11 others Yalamanchili, R., Lapham, K., Pocalyko, D., Sliskovic, D., Ciotti, S., Stoller, B., Hena, M. A., Ding, Q., Maiti, S. N., Stier, M. & Welgus, H. Nov 1 2007 In : Bioorganic and Medicinal Chemistry Letters. 17, 21, p. 5983-5988 6 p.

Research output: Contribution to journalArticle

Androgen Receptor Antagonists
Inbred C3H Mouse