Profile The profile is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Adenoviridae Medicine & Life Sciences
Vaccines Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Innate Immunity Medicine & Life Sciences
Antigens Medicine & Life Sciences
Natural Killer Cells Medicine & Life Sciences
Adaptive Immunity Medicine & Life Sciences
Genes Medicine & Life Sciences

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Grants 2015 2017

Publications 2009 2017

Decreased vector gene expression from e2b gene-deleted adenovirus serotype 5 vaccines intensifies proinflammatory immune responses

Quiroga, D., Aldhamen, Y. A., Godbehere, S., Harding, L. & Amalfitano, A. Jun 1 2017 In : Clinical and Vaccine Immunology. 24, 6, e00061-17

Research output: Research - peer-reviewArticle

Adenoviridae
Vaccines
Gene Expression
Genes
Serogroup

Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality

Rastall, D. P. W., Alyaquob, F. S., O'Connell, P., Pepelyayeva, Y., Peters, D., Godbehere-Roosa, S., Pereira-Hicks, C., Aldhamen, Y. A. & Amalfitano, A. Jun 1 2017 In : International Immunology. 29, 6, p. 277-289 13 p.

Research output: Research - peer-reviewArticle

Aminopeptidases
Perinatal Mortality
Ankylosing Spondylitis
Natural Killer Cells
Endoplasmic Reticulum
2 Citations

In vivo synthesis of cyclic-di-GMP using a recombinant adenovirus preferentially improves adaptive immune responses against extracellular antigens

Alyaqoub, F. S., Aldhamen, Y. A., Koestler, B. J., Bruger, E. L., Seregin, S. S., Pereira-Hicks, C., Godbehere, S., Waters, C. M. & Amalfitano, A. Feb 15 2016 In : Journal of Immunology. 196, 4, p. 1741-1752 12 p.

Research output: Research - peer-reviewArticle

Cyclic GMP
Adaptive Immunity
Adenoviridae
Antigens
bis(3',5')-cyclic diguanylic acid
5 Citations

Long-term, high-level hepatic secretion of acid α-glucosidase for Pompe disease achieved in non-human primates using helper-dependent adenovirus

Rastall, D. P. W., Seregin, S. S., Aldhamen, Y. A., Kaiser, L. M., Mullins, C., Liou, A., Ing, F., Pereria-Hicks, C., Godbehere-Roosa, S., Palmer, D., Ng, P. & Amalfitano, A. Jul 21 2016 (Accepted/In press) In : Gene Therapy.

Research output: Research - peer-reviewArticle

Glycogen Storage Disease Type II
alpha-Glucosidases
Adenoviridae
Primates
Acids

Methods to Mitigate Immune Responses to Adenoviral Vectors

Aldhamen, Y. A. & Amalfitano, A. Apr 6 2016 Adenoviral Vectors for Gene Therapy: Second Edition. Elsevier Inc., p. 391-422 32 p.

Research output: ResearchChapter

Adenoviridae
Gene transfer
Genetic Therapy
Genes
Gene therapy