A molecular lock-and-key approach to detecting solution phase self-assembly. A fluorescence and absorption study of carminic acid in aqueous glucose solutions

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    Abstract

    We introduce a novel approach to the study of complex ternary systems where a fluorescent chromophore contains a functionality that incorporates into precrystalline aggregates in concentrated solutions. We demonstrate the feasibility of this approach by using carminic acid, a fluorescent molecule possessing a pendant glycosyl moiety, in aqueous glucose solutions. We report the steady state absorption and emission response of carminic acid as well as its picosecond dynamical response. These data, taken collectively, show that saturated glucose solutions exhibit anomalous molecular scale organization and that the persistence time of this organization is significantly less than a nanosecond. Our results indicate that kinetic contributions to crystallization are expected to play an important, sometimes dominant, role in this technologically important process.

    Original languageEnglish (US)
    Pages (from-to)7220-7229
    Number of pages10
    JournalJournal of Physical Chemistry
    Volume100
    Issue number17
    StatePublished - Apr 25 1996

    Profile

    glucose
    acids
    Glucose
    Acids
    ternary systems
    chromophores
    self assembly
    crystallization
    fluorescence
    kinetics
    molecules
    Ternary systems
    Chromophores
    Self assembly
    Crystallization
    Fluorescence
    Molecules
    Kinetics
    Surgical Hemostasis

    ASJC Scopus subject areas

    • Physical and Theoretical Chemistry

    Cite this

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    title = "A molecular lock-and-key approach to detecting solution phase self-assembly. A fluorescence and absorption study of carminic acid in aqueous glucose solutions",
    abstract = "We introduce a novel approach to the study of complex ternary systems where a fluorescent chromophore contains a functionality that incorporates into precrystalline aggregates in concentrated solutions. We demonstrate the feasibility of this approach by using carminic acid, a fluorescent molecule possessing a pendant glycosyl moiety, in aqueous glucose solutions. We report the steady state absorption and emission response of carminic acid as well as its picosecond dynamical response. These data, taken collectively, show that saturated glucose solutions exhibit anomalous molecular scale organization and that the persistence time of this organization is significantly less than a nanosecond. Our results indicate that kinetic contributions to crystallization are expected to play an important, sometimes dominant, role in this technologically important process.",
    author = "Rasimas, {J. P.} and Berglund, {K. A.} and Blanchard, {G. J.}",
    year = "1996",
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    journal = "Journal of Physical Chemistry",
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    publisher = "American Chemical Society",
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    T1 - A molecular lock-and-key approach to detecting solution phase self-assembly. A fluorescence and absorption study of carminic acid in aqueous glucose solutions

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    AU - Berglund,K. A.

    AU - Blanchard,G. J.

    PY - 1996/4/25

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    N2 - We introduce a novel approach to the study of complex ternary systems where a fluorescent chromophore contains a functionality that incorporates into precrystalline aggregates in concentrated solutions. We demonstrate the feasibility of this approach by using carminic acid, a fluorescent molecule possessing a pendant glycosyl moiety, in aqueous glucose solutions. We report the steady state absorption and emission response of carminic acid as well as its picosecond dynamical response. These data, taken collectively, show that saturated glucose solutions exhibit anomalous molecular scale organization and that the persistence time of this organization is significantly less than a nanosecond. Our results indicate that kinetic contributions to crystallization are expected to play an important, sometimes dominant, role in this technologically important process.

    AB - We introduce a novel approach to the study of complex ternary systems where a fluorescent chromophore contains a functionality that incorporates into precrystalline aggregates in concentrated solutions. We demonstrate the feasibility of this approach by using carminic acid, a fluorescent molecule possessing a pendant glycosyl moiety, in aqueous glucose solutions. We report the steady state absorption and emission response of carminic acid as well as its picosecond dynamical response. These data, taken collectively, show that saturated glucose solutions exhibit anomalous molecular scale organization and that the persistence time of this organization is significantly less than a nanosecond. Our results indicate that kinetic contributions to crystallization are expected to play an important, sometimes dominant, role in this technologically important process.

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