A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways

Zheng Li, Shireesh Srivastava, Sheenu Mittal, Xuerui Yang, Lufang Sheng, Christina Chan

    Research output: Research - peer-reviewArticle

    • 18 Citations

    Abstract

    Background: The ability to obtain profiles of gene expressions, proteins and metabolites with the advent of high throughput technologies has advanced the study of pathway and network reconstruction. Genome-wide network reconstruction requires either interaction measurements or large amount of perturbation data, often not available for mammalian cell systems. To overcome these shortcomings, we developed a Three Stage Integrative Pathway Search (TIPS

    LanguageEnglish (US)
    Article number202
    JournalBMC Bioinformatics
    Volume8
    DOIs
    StatePublished - Jun 14 2007

    Profile

    Toxicity
    Pathway
    Gene
    Framework
    Metabolites
    Gene expression
    Genes
    Cells
    Throughput
    Proteins
    Genome
    Technology
    Data Perturbation
    High Throughput
    Gene Expression
    Protein
    Cell
    Interaction
    Background
    Profile

    ASJC Scopus subject areas

    • Medicine(all)
    • Structural Biology
    • Applied Mathematics

    Cite this

    A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways. / Li, Zheng; Srivastava, Shireesh; Mittal, Sheenu; Yang, Xuerui; Sheng, Lufang; Chan, Christina.

    In: BMC Bioinformatics, Vol. 8, 202, 14.06.2007.

    Research output: Research - peer-reviewArticle

    Li, Zheng ; Srivastava, Shireesh ; Mittal, Sheenu ; Yang, Xuerui ; Sheng, Lufang ; Chan, Christina. / A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways. In: BMC Bioinformatics. 2007 ; Vol. 8.
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