A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways

Zheng Li, Shireesh Srivastava, Sheenu Mittal, Xuerui Yang, Lufang Sheng, Christina Chan

    Research output: Contribution to journalArticle

    • 18 Citations

    Abstract

    Background: The ability to obtain profiles of gene expressions, proteins and metabolites with the advent of high throughput technologies has advanced the study of pathway and network reconstruction. Genome-wide network reconstruction requires either interaction measurements or large amount of perturbation data, often not available for mammalian cell systems. To overcome these shortcomings, we developed a Three Stage Integrative Pathway Search (TIPS

    Original languageEnglish (US)
    Article number202
    JournalBMC Bioinformatics
    Volume8
    DOIs
    StatePublished - Jun 14 2007

    Profile

    Cyclic AMP Receptor Protein
    Genes
    Genome
    Technology
    Proteins
    Pathway
    Acyclic Acids
    Buccal Administration
    MSH Release-Inhibiting Hormone
    Acrodermatitis
    Castration
    Gene expression
    Throughput
    Metabolites
    Toxicity
    Cells
    Data perturbation
    High throughput
    Gene
    Protein

    ASJC Scopus subject areas

    • Medicine(all)
    • Structural Biology
    • Applied Mathematics

    Cite this

    A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways. / Li, Zheng; Srivastava, Shireesh; Mittal, Sheenu; Yang, Xuerui; Sheng, Lufang; Chan, Christina.

    In: BMC Bioinformatics, Vol. 8, 202, 14.06.2007.

    Research output: Contribution to journalArticle

    Li, Zheng; Srivastava, Shireesh; Mittal, Sheenu; Yang, Xuerui; Sheng, Lufang; Chan, Christina / A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways.

    In: BMC Bioinformatics, Vol. 8, 202, 14.06.2007.

    Research output: Contribution to journalArticle

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