Absolute Stereochemical Determination of Asymmetric Sulfoxides via Central to Axial Induction of Chirality

Hadi Gholami, Jun Zhang, Mercy Anyika, Babak Borhan

    Research output: Research - peer-reviewArticle

    • 1 Citations

    Abstract

    The absolute configuration of chiral sulfoxides is determined by means of host-guest complexation that leads to the induction of axial chirality in an achiral host. The central to axial induction of helicity is rationalized by a simple recognition of the relative length and size of the substituents attached to the S-center. This technique is used to determine the absolute configuration of chiral sulfoxides, requiring micrograms of sample, without the need for prefunctionalization.

    LanguageEnglish (US)
    Pages1722-1725
    Number of pages4
    JournalOrganic Letters
    Volume19
    Issue number7
    DOIs
    StatePublished - Apr 7 2017

    Profile

    chirality
    induction
    configurations
    Sulfoxides
    Chirality
    Complexation

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

    Cite this

    Absolute Stereochemical Determination of Asymmetric Sulfoxides via Central to Axial Induction of Chirality. / Gholami, Hadi; Zhang, Jun; Anyika, Mercy; Borhan, Babak.

    In: Organic Letters, Vol. 19, No. 7, 07.04.2017, p. 1722-1725.

    Research output: Research - peer-reviewArticle

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