Assessment of early diastolic strain-velocity temporal relationships using spatial modulation of magnetization with polarity alternating velocity encoding (SPAMM-PAV)

Ziheng Zhang, Donald P. Dione, Peter B. Brown, Erik M. Shapiro, Albert J. Sinusas, Smita Sampath

Research output: Research - peer-reviewArticle

  • 1 Citations

Abstract

A novel MR imaging technique, spatial modulation of magnetization with polarity alternating velocity encoding (SPAMM-PAV), is presented to simultaneously examine the left ventricular early diastolic temporal relationships between myocardial deformation and intra-cavity hemodynamics with a high temporal resolution of 14 ms. This approach is initially evaluated in a dynamic flow and tissue mimicking phantom. A comparison of regional longitudinal strains and intra-cavity pressure differences (integration of computed in-plane pressure gradients within a selected region) in relation to mitral valve inflow velocities is performed in eight normal volunteers. Our results demonstrate that apical regions have higher strain rates (0.145 ± 0.005 %/ms) during the acceleration period of rapid filling compared to mid-ventricular (0.114 ± 0.007 %/ms) and basal regions (0.088 ± 0.009 %/ms), and apical strain curves plateau at peak mitral inflow velocity. This pattern is reversed during the deceleration period, when the strain-rates in the basal regions are the highest (0.027 ± 0.003 %/ms) due to ongoing basal stretching. A positive base-to-apex gradient in peak pressure difference is observed during acceleration, followed by a negative base-to-apex gradient during deceleration. These studies shed insight into the regional volumetric and pressure difference changes in the left ventricle during early diastolic filling.

LanguageEnglish (US)
Pages1627-1638
Number of pages12
JournalMagnetic Resonance in Medicine
Volume66
Issue number6
DOIs
StatePublished - Dec 2011
Externally publishedYes

Profile

Pressure
Deceleration
Mitral Valve
Heart Ventricles
Healthy Volunteers
Hemodynamics

Keywords

  • cardiac strain
  • diastole cardiac function
  • imaging
  • magnetic resonance
  • phase contrast
  • SPAMM
  • tagging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Assessment of early diastolic strain-velocity temporal relationships using spatial modulation of magnetization with polarity alternating velocity encoding (SPAMM-PAV). / Zhang, Ziheng; Dione, Donald P.; Brown, Peter B.; Shapiro, Erik M.; Sinusas, Albert J.; Sampath, Smita.

In: Magnetic Resonance in Medicine, Vol. 66, No. 6, 12.2011, p. 1627-1638.

Research output: Research - peer-reviewArticle

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