Association of Intraluminal Thrombus, Hemodynamic Forces, and Abdominal Aortic Aneurysm Expansion Using Longitudinal CT Images

Byron A. Zambrano, Hamidreza Gharahi, ChaeYoung Lim, Farhad A. Jaberi, Jongeun Choi, Whal Lee, Seungik Baek

    Research output: Contribution to journalArticle

    • 2 Citations

    Abstract

    While hemodynamic forces and intraluminal thrombus (ILT) are believed to play important roles on abdominal aortic aneurysm (AAA), it has been suggested that hemodynamic forces and ILT also interact with each other, making it a complex problem. There is, however, a pressing need to understand relationships among three factors: hemodynamics, ILT accumulation, and AAA expansion for AAA prognosis. Hence this study used longitudinal computer tomography scans from 14 patients and analyzed the relationship between them. Hemodynamic forces, represented by wall shear stress (WSS), were obtained from computational fluid dynamics; ILT accumulation was described by ILT thickness distribution changes between consecutives scans, and ILT accumulation and AAA expansion rates were estimated from changes in ILT and AAA volume. Results showed that, while low WSS was observed at regions where ILT accumulated, the rate at which ILT accumulated occurred at the same rate as the aneurysm expansion. Comparison between AAAs with and without thrombus showed that aneurysm with ILT recorded lower values of WSS and higher values of AAA expansion than those without thrombus. Findings suggest that low WSS may promote ILT accumulation and submit the idea that by increasing WSS levels ILT accumulation may be prevented.

    Original languageEnglish (US)
    JournalAnnals of Biomedical Engineering
    DOIs
    StateAccepted/In press - Oct 1 2015

    Profile

    Hemodynamics
    Shear stress
    Tomography
    Computational fluid dynamics
    Association reactions

    Keywords

    • CFD
    • Thrombosis
    • Vascular growth and remodeling

    ASJC Scopus subject areas

    • Biomedical Engineering

    Cite this

    Association of Intraluminal Thrombus, Hemodynamic Forces, and Abdominal Aortic Aneurysm Expansion Using Longitudinal CT Images. / Zambrano, Byron A.; Gharahi, Hamidreza; Lim, ChaeYoung; Jaberi, Farhad A.; Choi, Jongeun; Lee, Whal; Baek, Seungik.

    In: Annals of Biomedical Engineering, 01.10.2015.

    Research output: Contribution to journalArticle

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    abstract = "While hemodynamic forces and intraluminal thrombus (ILT) are believed to play important roles on abdominal aortic aneurysm (AAA), it has been suggested that hemodynamic forces and ILT also interact with each other, making it a complex problem. There is, however, a pressing need to understand relationships among three factors: hemodynamics, ILT accumulation, and AAA expansion for AAA prognosis. Hence this study used longitudinal computer tomography scans from 14 patients and analyzed the relationship between them. Hemodynamic forces, represented by wall shear stress (WSS), were obtained from computational fluid dynamics; ILT accumulation was described by ILT thickness distribution changes between consecutives scans, and ILT accumulation and AAA expansion rates were estimated from changes in ILT and AAA volume. Results showed that, while low WSS was observed at regions where ILT accumulated, the rate at which ILT accumulated occurred at the same rate as the aneurysm expansion. Comparison between AAAs with and without thrombus showed that aneurysm with ILT recorded lower values of WSS and higher values of AAA expansion than those without thrombus. Findings suggest that low WSS may promote ILT accumulation and submit the idea that by increasing WSS levels ILT accumulation may be prevented.",
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    AU - Jaberi,Farhad A.

    AU - Choi,Jongeun

    AU - Lee,Whal

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