ATR-FTIR for Determining Optimal Cooling Curves for Batch Crystallization of Succinic Acid

Lili Feng, Kris A. Berglund

    Research output: Contribution to journalArticle

    • 71 Citations

    Abstract

    The temperature profile applied during batch cooling crystallization affects the supersaturation level, which in turn affects the crystal size distribution. It is possible, in principle, to calculate the optimal cooling profile; however, the nucleation and growth kinetics are rarely known to the degree of accuracy necessary for this calculation. The current study demonstrates an alternative approach to determination of the optimal cooling profile without any prior knowledge of kinetic data or subsequent modeling. An attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectrometer was used to monitor the supersaturation level during batch cooling crystallization. The ATR-FTIR was interfaced to a LABMAX automatic reactor system that was used in a feedback mode to control the cooling rate so that the supersaturation level remained close to the solubility throughout the cooling process. The resulting temperature profile corresponds to the optimal operating conditions for the maximum in the mean crystal size.

    Original languageEnglish (US)
    Pages (from-to)449-452
    Number of pages4
    JournalCrystal Growth and Design
    Volume2
    Issue number5
    DOIs
    StatePublished - Sep 2002

    Profile

    cooling
    Amputees
    Cooling
    supersaturation
    crystallization
    reflectance
    Adnexal Diseases
    Erythrosine
    Histocompatibility
    Supersaturation
    Fourier transforms
    Crystallization
    temperature profiles
    kinetics
    profiles
    crystals
    Acetanilides
    Carcinoid Tumor
    Biological Availability
    Infrared radiation

    ASJC Scopus subject areas

    • Chemistry(all)
    • Materials Science(all)
    • Condensed Matter Physics

    Cite this

    ATR-FTIR for Determining Optimal Cooling Curves for Batch Crystallization of Succinic Acid. / Feng, Lili; Berglund, Kris A.

    In: Crystal Growth and Design, Vol. 2, No. 5, 09.2002, p. 449-452.

    Research output: Contribution to journalArticle

    Feng, Lili; Berglund, Kris A. / ATR-FTIR for Determining Optimal Cooling Curves for Batch Crystallization of Succinic Acid.

    In: Crystal Growth and Design, Vol. 2, No. 5, 09.2002, p. 449-452.

    Research output: Contribution to journalArticle

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