Biocompatibility evaluation of Ti-15Al-33Nb(at %) and Ti-21Al-29Nb(at %)

Carl J. Boehlert, Katherine A. Rider, Lisa M. Flick

Research output: Contribution to journalArticle

  • 2 Citations

Abstract

In this work the biocompatibility of two vanadium-free Ti-Al-Nb alloys, Ti-15Al-33Nb and Ti-21Al-29Nb, was evaluated and compared to that for commercially pure titanium (CP Ti) and alumina (Al2O3). Fine particles were milled from sheet-processed material and implanted onto mice calvaria using an established animal model. Various stains, including methylene blue/acid fuchsin, TRAcP, and immunohistochemistry, were used on the particle-treated calvaria to measure the extent of bone deterioration of the calvaria, quantify the amount of osteoclasts, and approximate the presence of T-cells. In addition, reaction with particle-stimulated macrophages was observed and the production of the cytokine TNFα was recorded and quantified. The results indicated that the Ti-Al-Nb alloys statistically outperformed both CP Ti and Al2O3 in terms of their overall biocompatibility with respect to the experiments performed.

LanguageEnglish (US)
Pages1618-1626
Number of pages9
JournalMaterials Transactions
Volume46
Issue number7
DOIs
StatePublished - Jul 2005

Profile

biocompatibility
Titanium
Biocompatibility
Vanadium
Addition reactions
T-cells
Aluminum Oxide
evaluation
Macrophages
Methylene Blue
titanium
Deterioration
Bone
Animals
animal models
macrophages
Coloring Agents
Alumina
methylene blue
Cytokines

Keywords

  • Biocompatibility
  • Osteoclasts
  • Particles
  • Stains
  • T-cells
  • Titanium-aluminum-niobium alloy

ASJC Scopus subject areas

  • Materials Science(all)
  • Metals and Alloys

Cite this

Biocompatibility evaluation of Ti-15Al-33Nb(at %) and Ti-21Al-29Nb(at %). / Boehlert, Carl J.; Rider, Katherine A.; Flick, Lisa M.

In: Materials Transactions, Vol. 46, No. 7, 07.2005, p. 1618-1626.

Research output: Contribution to journalArticle

Boehlert, Carl J. ; Rider, Katherine A. ; Flick, Lisa M./ Biocompatibility evaluation of Ti-15Al-33Nb(at %) and Ti-21Al-29Nb(at %). In: Materials Transactions. 2005 ; Vol. 46, No. 7. pp. 1618-1626
@article{56d6ab5bf5e64232938912fb0cbaaf3f,
title = "Biocompatibility evaluation of Ti-15Al-33Nb(at {\%}) and Ti-21Al-29Nb(at {\%})",
abstract = "In this work the biocompatibility of two vanadium-free Ti-Al-Nb alloys, Ti-15Al-33Nb and Ti-21Al-29Nb, was evaluated and compared to that for commercially pure titanium (CP Ti) and alumina (Al2O3). Fine particles were milled from sheet-processed material and implanted onto mice calvaria using an established animal model. Various stains, including methylene blue/acid fuchsin, TRAcP, and immunohistochemistry, were used on the particle-treated calvaria to measure the extent of bone deterioration of the calvaria, quantify the amount of osteoclasts, and approximate the presence of T-cells. In addition, reaction with particle-stimulated macrophages was observed and the production of the cytokine TNFα was recorded and quantified. The results indicated that the Ti-Al-Nb alloys statistically outperformed both CP Ti and Al2O3 in terms of their overall biocompatibility with respect to the experiments performed.",
keywords = "Biocompatibility, Osteoclasts, Particles, Stains, T-cells, Titanium-aluminum-niobium alloy",
author = "Boehlert, {Carl J.} and Rider, {Katherine A.} and Flick, {Lisa M.}",
year = "2005",
month = "7",
doi = "10.2320/matertrans.46.1618",
language = "English (US)",
volume = "46",
pages = "1618--1626",
journal = "Materials Transactions",
issn = "1345-9678",
publisher = "Japan Institute of Metals (JIM)",
number = "7",

}

TY - JOUR

T1 - Biocompatibility evaluation of Ti-15Al-33Nb(at %) and Ti-21Al-29Nb(at %)

AU - Boehlert,Carl J.

AU - Rider,Katherine A.

AU - Flick,Lisa M.

PY - 2005/7

Y1 - 2005/7

N2 - In this work the biocompatibility of two vanadium-free Ti-Al-Nb alloys, Ti-15Al-33Nb and Ti-21Al-29Nb, was evaluated and compared to that for commercially pure titanium (CP Ti) and alumina (Al2O3). Fine particles were milled from sheet-processed material and implanted onto mice calvaria using an established animal model. Various stains, including methylene blue/acid fuchsin, TRAcP, and immunohistochemistry, were used on the particle-treated calvaria to measure the extent of bone deterioration of the calvaria, quantify the amount of osteoclasts, and approximate the presence of T-cells. In addition, reaction with particle-stimulated macrophages was observed and the production of the cytokine TNFα was recorded and quantified. The results indicated that the Ti-Al-Nb alloys statistically outperformed both CP Ti and Al2O3 in terms of their overall biocompatibility with respect to the experiments performed.

AB - In this work the biocompatibility of two vanadium-free Ti-Al-Nb alloys, Ti-15Al-33Nb and Ti-21Al-29Nb, was evaluated and compared to that for commercially pure titanium (CP Ti) and alumina (Al2O3). Fine particles were milled from sheet-processed material and implanted onto mice calvaria using an established animal model. Various stains, including methylene blue/acid fuchsin, TRAcP, and immunohistochemistry, were used on the particle-treated calvaria to measure the extent of bone deterioration of the calvaria, quantify the amount of osteoclasts, and approximate the presence of T-cells. In addition, reaction with particle-stimulated macrophages was observed and the production of the cytokine TNFα was recorded and quantified. The results indicated that the Ti-Al-Nb alloys statistically outperformed both CP Ti and Al2O3 in terms of their overall biocompatibility with respect to the experiments performed.

KW - Biocompatibility

KW - Osteoclasts

KW - Particles

KW - Stains

KW - T-cells

KW - Titanium-aluminum-niobium alloy

UR - http://www.scopus.com/inward/record.url?scp=24944519915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24944519915&partnerID=8YFLogxK

U2 - 10.2320/matertrans.46.1618

DO - 10.2320/matertrans.46.1618

M3 - Article

VL - 46

SP - 1618

EP - 1626

JO - Materials Transactions

T2 - Materials Transactions

JF - Materials Transactions

SN - 1345-9678

IS - 7

ER -