Biocompatibility evaluation of Ti-15Al-33Nb(at %) and Ti-21Al-29Nb(at %)

Carl J. Boehlert, Katherine A. Rider, Lisa M. Flick

    Research output: Contribution to journalArticle

    • 1 Citations

    Abstract

    In this work the biocompatibility of two vanadium-free Ti-Al-Nb alloys, Ti-15Al-33Nb and Ti-21Al-29Nb, was evaluated and compared to that for commercially pure titanium (CP Ti) and alumina (Al2O3). Fine particles were milled from sheet-processed material and implanted onto mice calvaria using an established animal model. Various stains, including methylene blue/acid fuchsin, TRAcP, and immunohistochemistry, were used on the particle-treated calvaria to measure the extent of bone deterioration of the calvaria, quantify the amount of osteoclasts, and approximate the presence of T-cells. In addition, reaction with particle-stimulated macrophages was observed and the production of the cytokine TNFα was recorded and quantified. The results indicated that the Ti-Al-Nb alloys statistically outperformed both CP Ti and Al2O3 in terms of their overall biocompatibility with respect to the experiments performed.

    Original languageEnglish (US)
    Pages (from-to)1618-1626
    Number of pages9
    JournalMaterials Transactions
    Volume46
    Issue number7
    DOIs
    StatePublished - Jul 2005

    Profile

    biocompatibility
    Biocompatibility
    Baclofen
    titanium
    Titanium
    animal models
    macrophages
    methylene blue
    deterioration
    vanadium
    bones
    mice
    aluminum oxides
    acids
    evaluation
    Addition reactions
    T-cells
    Macrophages
    Vanadium
    Deterioration

    Keywords

    • Biocompatibility
    • Osteoclasts
    • Particles
    • Stains
    • T-cells
    • Titanium-aluminum-niobium alloy

    ASJC Scopus subject areas

    • Materials Science(all)
    • Metals and Alloys

    Cite this

    Biocompatibility evaluation of Ti-15Al-33Nb(at %) and Ti-21Al-29Nb(at %). / Boehlert, Carl J.; Rider, Katherine A.; Flick, Lisa M.

    In: Materials Transactions, Vol. 46, No. 7, 07.2005, p. 1618-1626.

    Research output: Contribution to journalArticle

    Boehlert, Carl J.; Rider, Katherine A.; Flick, Lisa M. / Biocompatibility evaluation of Ti-15Al-33Nb(at %) and Ti-21Al-29Nb(at %).

    In: Materials Transactions, Vol. 46, No. 7, 07.2005, p. 1618-1626.

    Research output: Contribution to journalArticle

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