Biodegradable, polymer encapsulated, metal oxide particles for MRI-based cell tracking

    Research output: Research - peer-reviewArticle

    • 11 Citations

    Abstract

    Metallic particles have shaped the use of magnetic resonance imaging (MRI) for molecular and cellular imaging. Although these particles have generally been developed for extracellular residence, either as blood pool contrast agents or targeted contrast agents, the coopted use of these particles for intracellular labeling has grown over the last 20 years. Coincident with this growth has been the development of metal oxide particles specifically intended for intracellular residence, and innovations in the nature of the metallic core. One promising nanoparticle construct for MRI-based cell tracking is polymer encapsulated metal oxide nanoparticles. Rather than a polymer coated metal oxide nanocrystal of the core: shell type, polymer encapsulated metal oxide nanoparticles cluster many nanocrystals within a polymer matrix. This nanoparticle composite more efficiently packages inorganic nanocrystals, affording the ability to label cells with more inorganic material. Further, for magnetic nanocrystals, the clustering of multiple magnetic nanocrystals within a single nanoparticle enhances r2 and r2 relaxivity. Methods for fabricating polymer encapsulated metal oxide nanoparticles are facile, yielding both varied compositions and synthetic approaches. This review presents a brief history into the use of metal oxide particles for MRI-based cell tracking and details the development and use of biodegradable, polymer encapsulated, metal oxide nanoparticles and microparticles for MRI-based cell tracking.

    LanguageEnglish (US)
    Pages376-389
    Number of pages14
    JournalMagnetic Resonance in Medicine
    Volume73
    Issue number1
    DOIs
    StatePublished - Jan 1 2015

    Profile

    Cell Tracking
    Nanoparticles
    Oxides
    Polymers
    Metals
    Magnetic Resonance Imaging
    Metal Nanoparticles
    Contrast Media
    Molecular Imaging
    Cluster Analysis
    History
    Growth

    Keywords

    • Iron oxide
    • MRI
    • Particles
    • Polymer
    • Stem cells

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Biodegradable, polymer encapsulated, metal oxide particles for MRI-based cell tracking. / Shapiro, Erik M.

    In: Magnetic Resonance in Medicine, Vol. 73, No. 1, 01.01.2015, p. 376-389.

    Research output: Research - peer-reviewArticle

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