Bistable Signaling Motifs and Cell Fate Decisions

Sudin Bhattacharya, Qiang Zhang, Melvin E. Andersen

Research output: ResearchChapter

  • 1 Citations
LanguageEnglish (US)
Title of host publicationQuantitative Modeling in Toxicology
PublisherJohn Wiley and Sons
Pages181-198
Number of pages18
ISBN (Print)9780470998090
DOIs
StatePublished - Mar 30 2010
Externally publishedYes

Keywords

  • "Cellular fates" - developmental states or processes, discrete, stable and mutually exclusive
  • Biological switches and signaling motifs
  • Bistability in gene autoregulation motif - response motifs, simple building blocks in complex molecular networks
  • Bistable signaling motifs and cell fate decisions
  • Bistable system, exhibiting hysteresis - and different dose-response curves
  • Key events in development of idea of bistability
  • M-nullcline, steady-state response of variable M to variable P -and P-nullcline, steady-state response of variable P to variable M
  • Molecular control processes for switching - nonlinear using autoregulatory feedback loops
  • Switching and bistability and "bifurcation diagram"
  • Ultrasensitivity in feedback loop and sigmoidal shape of M-nullcline - and multiple steady states for system

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Bhattacharya, S., Zhang, Q., & Andersen, M. E. (2010). Bistable Signaling Motifs and Cell Fate Decisions. In Quantitative Modeling in Toxicology (pp. 181-198). John Wiley and Sons. DOI: 10.1002/9780470686263.ch8

Bistable Signaling Motifs and Cell Fate Decisions. / Bhattacharya, Sudin; Zhang, Qiang; Andersen, Melvin E.

Quantitative Modeling in Toxicology. John Wiley and Sons, 2010. p. 181-198.

Research output: ResearchChapter

Bhattacharya, S, Zhang, Q & Andersen, ME 2010, Bistable Signaling Motifs and Cell Fate Decisions. in Quantitative Modeling in Toxicology. John Wiley and Sons, pp. 181-198. DOI: 10.1002/9780470686263.ch8
Bhattacharya S, Zhang Q, Andersen ME. Bistable Signaling Motifs and Cell Fate Decisions. In Quantitative Modeling in Toxicology. John Wiley and Sons. 2010. p. 181-198. Available from, DOI: 10.1002/9780470686263.ch8
Bhattacharya, Sudin ; Zhang, Qiang ; Andersen, Melvin E./ Bistable Signaling Motifs and Cell Fate Decisions. Quantitative Modeling in Toxicology. John Wiley and Sons, 2010. pp. 181-198
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