Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

Hirosha Geekiyanage, Gregory A. Jicha, Peter T. Nelson, Christina Chan

Research output: Contribution to journalArticle

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Abstract

There is an urgent need to identify non-invasive biomarkers for the detection of sporadic Alzheimer's disease (AD). We previously studied microRNAs (miRNAs) in AD autopsy brain samples and reported a connection between miR-137, -181c, -9, -29a/b and AD, through the regulation of ceramides. In this study, the potential role of these miRNAs as diagnostic markers for AD was investigated. We identified that these miRNAs were down-regulated in the blood serum of probable AD patients. The levels of these miRNAs were also reduced in the serum of AD risk factor models. Although the ability of these miRNAs to conclusively diagnose for AD is currently unknown, our findings suggest a potential use for circulating miRNAs, along with other markers, as non-invasive and relatively inexpensive biomarkers for the early diagnosis of AD, however, with further research and validation.

LanguageEnglish (US)
Pages491-496
Number of pages6
JournalExperimental Neurology
Volume235
Issue number2
DOIs
StatePublished - Jun 2012

Profile

MicroRNAs
Alzheimer Disease
Biomarkers
Serum
Aptitude
Ceramides
Early Diagnosis
Autopsy
Brain
Research

Keywords

  • Alzheimer's disease
  • Blood serum
  • MicroRNA

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

Blood serum miRNA : Non-invasive biomarkers for Alzheimer's disease. / Geekiyanage, Hirosha; Jicha, Gregory A.; Nelson, Peter T.; Chan, Christina.

In: Experimental Neurology, Vol. 235, No. 2, 06.2012, p. 491-496.

Research output: Contribution to journalArticle

Geekiyanage H, Jicha GA, Nelson PT, Chan C. Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease. Experimental Neurology. 2012 Jun;235(2):491-496. Available from, DOI: 10.1016/j.expneurol.2011.11.026
Geekiyanage, Hirosha ; Jicha, Gregory A. ; Nelson, Peter T. ; Chan, Christina. / Blood serum miRNA : Non-invasive biomarkers for Alzheimer's disease. In: Experimental Neurology. 2012 ; Vol. 235, No. 2. pp. 491-496
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