Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

Hirosha Geekiyanage, Gregory A. Jicha, Peter T. Nelson, Christina Chan

    Research output: Contribution to journalArticle

    • 127 Citations

    Abstract

    There is an urgent need to identify non-invasive biomarkers for the detection of sporadic Alzheimer's disease (AD). We previously studied microRNAs (miRNAs) in AD autopsy brain samples and reported a connection between miR-137, -181c, -9, -29a/b and AD, through the regulation of ceramides. In this study, the potential role of these miRNAs as diagnostic markers for AD was investigated. We identified that these miRNAs were down-regulated in the blood serum of probable AD patients. The levels of these miRNAs were also reduced in the serum of AD risk factor models. Although the ability of these miRNAs to conclusively diagnose for AD is currently unknown, our findings suggest a potential use for circulating miRNAs, along with other markers, as non-invasive and relatively inexpensive biomarkers for the early diagnosis of AD, however, with further research and validation.

    Original languageEnglish (US)
    Pages (from-to)491-496
    Number of pages6
    JournalExperimental Neurology
    Volume235
    Issue number2
    DOIs
    StatePublished - Jun 2012

    Profile

    MicroRNAs
    Alzheimer Disease
    Biological Markers
    Serum
    Ceramides
    Early Diagnosis
    Autopsy
    Brain

    Keywords

    • Alzheimer's disease
    • Blood serum
    • MicroRNA

    ASJC Scopus subject areas

    • Neurology
    • Developmental Neuroscience

    Cite this

    Blood serum miRNA : Non-invasive biomarkers for Alzheimer's disease. / Geekiyanage, Hirosha; Jicha, Gregory A.; Nelson, Peter T.; Chan, Christina.

    In: Experimental Neurology, Vol. 235, No. 2, 06.2012, p. 491-496.

    Research output: Contribution to journalArticle

    Geekiyanage H, Jicha GA, Nelson PT, Chan C. Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease. Experimental Neurology. 2012 Jun;235(2):491-496. Available from, DOI: 10.1016/j.expneurol.2011.11.026

    Geekiyanage, Hirosha; Jicha, Gregory A.; Nelson, Peter T.; Chan, Christina / Blood serum miRNA : Non-invasive biomarkers for Alzheimer's disease.

    In: Experimental Neurology, Vol. 235, No. 2, 06.2012, p. 491-496.

    Research output: Contribution to journalArticle

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