Cartilage volume quantification via Live Wire segmentation

Alexander J. Gougoutas, Andrew J. Wheaton, Arijitt Borthakur, Erik M. Shapiro, J. Bruce Kneeland, Jayaram K. Udupa, Ravinder Reddy

Research output: Contribution to journalArticle

  • 34 Citations

Abstract

A reduction in cartilage volume is characteristic of osteoarthritis and hence there exists a need for an accurate and reproducible method to measure in vivo cartilage volume. Quantification of cartilage volume from magnetic resonance (MR) images requires a segmentation technique such as the user-driven "Live Wire" strategy that can reliably delineate object volumes in a time-efficient manner. In the present work, the accuracy and reproducibility of the Live Wire method for the quantification of cartilage volume in MR images is evaluated. The accuracy of the Live Wire method was assessed by comparing the MR-based volume measurement of a patellar cartilage-shaped phantom versus data calculated via water displacement. The inter- and intra-operator reproducibility of the technique was evaluated from Live Wire segmentation of the patellar cartilage volume from fat-suppressed 3-dimensional spoiled-gradient-echo images of five healthy human volunteers performed by three operators. To provide data for analysis of inter-scan reproducibility, the human scans were repeated five times with the aid of a leg-restraining jig to minimize repositioning error. The volume of the patellar cartilage-shaped phantom measured via Live Wire segmentation of MR images was within 97.8% of its true volume. The average inter- and intra-operator coefficients of variation of three operators were 3.0% and 0.4%, respectively. The average inter-scan coefficient of variation of five repeated scans of each volunteer was 2.7%. The data suggest that the Live Wire strategy is an accurate, reproducible, and efficient technique to measure cartilage volume in vivo in a feasible amount of operator time.

Original languageEnglish (US)
Pages (from-to)1389-1395
Number of pages7
JournalAcademic Radiology
Volume11
Issue number12
DOIs
StatePublished - Dec 2004
Externally publishedYes

Profile

Cartilage
Magnetic Resonance Spectroscopy
Osteoarthritis
Volunteers
Leg
Healthy Volunteers
Fats
Water

Keywords

  • Cartilage
  • Live Wire
  • segmentation
  • volume

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Gougoutas, A. J., Wheaton, A. J., Borthakur, A., Shapiro, E. M., Kneeland, J. B., Udupa, J. K., & Reddy, R. (2004). Cartilage volume quantification via Live Wire segmentation. Academic Radiology, 11(12), 1389-1395. DOI: 10.1016/j.acra.2004.09.003

Cartilage volume quantification via Live Wire segmentation. / Gougoutas, Alexander J.; Wheaton, Andrew J.; Borthakur, Arijitt; Shapiro, Erik M.; Kneeland, J. Bruce; Udupa, Jayaram K.; Reddy, Ravinder.

In: Academic Radiology, Vol. 11, No. 12, 12.2004, p. 1389-1395.

Research output: Contribution to journalArticle

Gougoutas, AJ, Wheaton, AJ, Borthakur, A, Shapiro, EM, Kneeland, JB, Udupa, JK & Reddy, R 2004, 'Cartilage volume quantification via Live Wire segmentation' Academic Radiology, vol 11, no. 12, pp. 1389-1395. DOI: 10.1016/j.acra.2004.09.003
Gougoutas AJ, Wheaton AJ, Borthakur A, Shapiro EM, Kneeland JB, Udupa JK et al. Cartilage volume quantification via Live Wire segmentation. Academic Radiology. 2004 Dec;11(12):1389-1395. Available from, DOI: 10.1016/j.acra.2004.09.003

Gougoutas, Alexander J.; Wheaton, Andrew J.; Borthakur, Arijitt; Shapiro, Erik M.; Kneeland, J. Bruce; Udupa, Jayaram K.; Reddy, Ravinder / Cartilage volume quantification via Live Wire segmentation.

In: Academic Radiology, Vol. 11, No. 12, 12.2004, p. 1389-1395.

Research output: Contribution to journalArticle

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