Cellular Magnetic Resonance Imaging: Nanometer and Micrometer Size Particles for Noninvasive Cell Localization

Jonathan R. Slotkin, Kevin S. Cahill, Suzanne A. Tharin, Erik M. Shapiro

Research output: Contribution to journalArticle

  • 43 Citations

Abstract

The use of nanometer and micrometer-sized superparamagnetic iron oxide particles as cellular contrast agents allows for the noninvasive detection of labeled cells on high-resolution magnetic resonance images. The development and application of these techniques to neurologic disorders is likely to accelerate the development of cell transplantation therapies and allow for the detailed study of in vivo cellular biology. This review summarizes the early development of iron oxide-based cellular contrast agents and the more recent application of this technology to noninvasive imaging of cellular transplants. The ability of this technique to allow for the noninvasive detection of in vivo transplants on the single-cell level is highlighted.

Original languageEnglish (US)
Pages (from-to)428-433
Number of pages6
JournalNeurotherapeutics
Volume4
Issue number3
DOIs
StatePublished - Jul 2007
Externally publishedYes

Profile

Particle Size
Oxides
Contrast Media
Iron
Magnetic Resonance Imaging
Transplants
Cell Transplantation
Cell- and Tissue-Based Therapy
Nervous System Diseases
Cell Biology
Magnetic Resonance Spectroscopy
Technology

Keywords

  • brain
  • iron oxide
  • magnetic resonance imaging
  • single-cell imaging
  • Stem cells
  • superparamagnetic contrast agents

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Pharmacology

Cite this

Cellular Magnetic Resonance Imaging : Nanometer and Micrometer Size Particles for Noninvasive Cell Localization. / Slotkin, Jonathan R.; Cahill, Kevin S.; Tharin, Suzanne A.; Shapiro, Erik M.

In: Neurotherapeutics, Vol. 4, No. 3, 07.2007, p. 428-433.

Research output: Contribution to journalArticle

Slotkin, Jonathan R.; Cahill, Kevin S.; Tharin, Suzanne A.; Shapiro, Erik M. / Cellular Magnetic Resonance Imaging : Nanometer and Micrometer Size Particles for Noninvasive Cell Localization.

In: Neurotherapeutics, Vol. 4, No. 3, 07.2007, p. 428-433.

Research output: Contribution to journalArticle

@article{dcfc678ffa9142f6b4eec7fc871b0deb,
title = "Cellular Magnetic Resonance Imaging: Nanometer and Micrometer Size Particles for Noninvasive Cell Localization",
abstract = "The use of nanometer and micrometer-sized superparamagnetic iron oxide particles as cellular contrast agents allows for the noninvasive detection of labeled cells on high-resolution magnetic resonance images. The development and application of these techniques to neurologic disorders is likely to accelerate the development of cell transplantation therapies and allow for the detailed study of in vivo cellular biology. This review summarizes the early development of iron oxide-based cellular contrast agents and the more recent application of this technology to noninvasive imaging of cellular transplants. The ability of this technique to allow for the noninvasive detection of in vivo transplants on the single-cell level is highlighted.",
keywords = "brain, iron oxide, magnetic resonance imaging, single-cell imaging, Stem cells, superparamagnetic contrast agents",
author = "Slotkin, {Jonathan R.} and Cahill, {Kevin S.} and Tharin, {Suzanne A.} and Shapiro, {Erik M.}",
year = "2007",
month = "7",
doi = "10.1016/j.nurt.2007.05.010",
volume = "4",
pages = "428--433",
journal = "Neurotherapeutics",
issn = "1933-7213",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Cellular Magnetic Resonance Imaging

T2 - Neurotherapeutics

AU - Slotkin,Jonathan R.

AU - Cahill,Kevin S.

AU - Tharin,Suzanne A.

AU - Shapiro,Erik M.

PY - 2007/7

Y1 - 2007/7

N2 - The use of nanometer and micrometer-sized superparamagnetic iron oxide particles as cellular contrast agents allows for the noninvasive detection of labeled cells on high-resolution magnetic resonance images. The development and application of these techniques to neurologic disorders is likely to accelerate the development of cell transplantation therapies and allow for the detailed study of in vivo cellular biology. This review summarizes the early development of iron oxide-based cellular contrast agents and the more recent application of this technology to noninvasive imaging of cellular transplants. The ability of this technique to allow for the noninvasive detection of in vivo transplants on the single-cell level is highlighted.

AB - The use of nanometer and micrometer-sized superparamagnetic iron oxide particles as cellular contrast agents allows for the noninvasive detection of labeled cells on high-resolution magnetic resonance images. The development and application of these techniques to neurologic disorders is likely to accelerate the development of cell transplantation therapies and allow for the detailed study of in vivo cellular biology. This review summarizes the early development of iron oxide-based cellular contrast agents and the more recent application of this technology to noninvasive imaging of cellular transplants. The ability of this technique to allow for the noninvasive detection of in vivo transplants on the single-cell level is highlighted.

KW - brain

KW - iron oxide

KW - magnetic resonance imaging

KW - single-cell imaging

KW - Stem cells

KW - superparamagnetic contrast agents

UR - http://www.scopus.com/inward/record.url?scp=34250727985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250727985&partnerID=8YFLogxK

U2 - 10.1016/j.nurt.2007.05.010

DO - 10.1016/j.nurt.2007.05.010

M3 - Article

VL - 4

SP - 428

EP - 433

JO - Neurotherapeutics

JF - Neurotherapeutics

SN - 1933-7213

IS - 3

ER -