Cellular to tissue informatics: Approaches to optimizing cellular function of engineered tissue

Sachin Patil, Zheng Li, Christina Chan

    Research output: Contribution to journalArticle

    • 4 Citations

    Abstract

    Tissue engineering is a rapidly expanding, multi-disciplinary field in biomedicine. It provides the ability to manipulate living cells and biomaterials for the purpose of restoring, maintaining, and enhancing tissue and organ function. Scientists have engineered various tissues in the body, from skin substitutes to artificial nerves to heart tissues, with varying degrees of success. Although the field of tissue engineering has come a long way since its first successful demonstration by Bisceglie in the 1930s, methods of coaxing them into functional tissues have been predominantly empirical to date. To successfully develop tissue-engineered organs, it is important to understand how to maintain the cells under conditions that maximize their ability to perform their physiological roles, regardless of their environment. In that context, a methodology that combines empirical data with mathematical and statistical techniques, such as metabolic engineering and cellular informatics, to systematically determine the optimal (1) type of cell to use, (2) scaffold properties and the corresponding processing conditions to achieve those properties, and (3) the required types and levels of environmental factors and the operating conditions needed in the bioreactor, will enable the design of viable and functional tissues tailored to the specific requirements of individual situations.

    Original languageEnglish (US)
    Pages (from-to)139-159
    Number of pages21
    JournalAdvances in Biochemical Engineering/Biotechnology
    Volume102
    DOIs
    StatePublished - Jul 15 2006

    Profile

    Library Catalogs
    Tissue
    Tissue Engineering
    Myoclonic Cerebellar Dyssynergia
    Tissue engineering
    Artificial Skin
    Metabolic Engineering
    Biocompatible Materials
    Bioreactors
    Accessory Nerve
    Metabolic engineering
    Cephalothin
    Aminopyrine
    Castration
    Scaffolds
    Demonstrations
    Biomaterials
    Skin
    Cells

    ASJC Scopus subject areas

    • Biotechnology
    • Bioengineering
    • Applied Microbiology and Biotechnology

    Cite this

    Cellular to tissue informatics : Approaches to optimizing cellular function of engineered tissue. / Patil, Sachin; Li, Zheng; Chan, Christina.

    In: Advances in Biochemical Engineering/Biotechnology, Vol. 102, 15.07.2006, p. 139-159.

    Research output: Contribution to journalArticle

    Patil, Sachin; Li, Zheng; Chan, Christina / Cellular to tissue informatics : Approaches to optimizing cellular function of engineered tissue.

    In: Advances in Biochemical Engineering/Biotechnology, Vol. 102, 15.07.2006, p. 139-159.

    Research output: Contribution to journalArticle

    @article{2671d363504f45c3a9a26006d2860bcc,
    title = "Cellular to tissue informatics: Approaches to optimizing cellular function of engineered tissue",
    abstract = "Tissue engineering is a rapidly expanding, multi-disciplinary field in biomedicine. It provides the ability to manipulate living cells and biomaterials for the purpose of restoring, maintaining, and enhancing tissue and organ function. Scientists have engineered various tissues in the body, from skin substitutes to artificial nerves to heart tissues, with varying degrees of success. Although the field of tissue engineering has come a long way since its first successful demonstration by Bisceglie in the 1930s, methods of coaxing them into functional tissues have been predominantly empirical to date. To successfully develop tissue-engineered organs, it is important to understand how to maintain the cells under conditions that maximize their ability to perform their physiological roles, regardless of their environment. In that context, a methodology that combines empirical data with mathematical and statistical techniques, such as metabolic engineering and cellular informatics, to systematically determine the optimal (1) type of cell to use, (2) scaffold properties and the corresponding processing conditions to achieve those properties, and (3) the required types and levels of environmental factors and the operating conditions needed in the bioreactor, will enable the design of viable and functional tissues tailored to the specific requirements of individual situations.",
    author = "Sachin Patil and Zheng Li and Christina Chan",
    year = "2006",
    month = "7",
    doi = "10.1007/10_009",
    volume = "102",
    pages = "139--159",
    journal = "Advances in Biochemical Engineering/Biotechnology",
    issn = "0724-6145",
    publisher = "Springer Science and Business Media Deutschland GmbH",

    }

    TY - JOUR

    T1 - Cellular to tissue informatics

    T2 - Advances in Biochemical Engineering/Biotechnology

    AU - Patil,Sachin

    AU - Li,Zheng

    AU - Chan,Christina

    PY - 2006/7/15

    Y1 - 2006/7/15

    N2 - Tissue engineering is a rapidly expanding, multi-disciplinary field in biomedicine. It provides the ability to manipulate living cells and biomaterials for the purpose of restoring, maintaining, and enhancing tissue and organ function. Scientists have engineered various tissues in the body, from skin substitutes to artificial nerves to heart tissues, with varying degrees of success. Although the field of tissue engineering has come a long way since its first successful demonstration by Bisceglie in the 1930s, methods of coaxing them into functional tissues have been predominantly empirical to date. To successfully develop tissue-engineered organs, it is important to understand how to maintain the cells under conditions that maximize their ability to perform their physiological roles, regardless of their environment. In that context, a methodology that combines empirical data with mathematical and statistical techniques, such as metabolic engineering and cellular informatics, to systematically determine the optimal (1) type of cell to use, (2) scaffold properties and the corresponding processing conditions to achieve those properties, and (3) the required types and levels of environmental factors and the operating conditions needed in the bioreactor, will enable the design of viable and functional tissues tailored to the specific requirements of individual situations.

    AB - Tissue engineering is a rapidly expanding, multi-disciplinary field in biomedicine. It provides the ability to manipulate living cells and biomaterials for the purpose of restoring, maintaining, and enhancing tissue and organ function. Scientists have engineered various tissues in the body, from skin substitutes to artificial nerves to heart tissues, with varying degrees of success. Although the field of tissue engineering has come a long way since its first successful demonstration by Bisceglie in the 1930s, methods of coaxing them into functional tissues have been predominantly empirical to date. To successfully develop tissue-engineered organs, it is important to understand how to maintain the cells under conditions that maximize their ability to perform their physiological roles, regardless of their environment. In that context, a methodology that combines empirical data with mathematical and statistical techniques, such as metabolic engineering and cellular informatics, to systematically determine the optimal (1) type of cell to use, (2) scaffold properties and the corresponding processing conditions to achieve those properties, and (3) the required types and levels of environmental factors and the operating conditions needed in the bioreactor, will enable the design of viable and functional tissues tailored to the specific requirements of individual situations.

    UR - http://www.scopus.com/inward/record.url?scp=33750254831&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=33750254831&partnerID=8YFLogxK

    U2 - 10.1007/10_009

    DO - 10.1007/10_009

    M3 - Article

    VL - 102

    SP - 139

    EP - 159

    JO - Advances in Biochemical Engineering/Biotechnology

    JF - Advances in Biochemical Engineering/Biotechnology

    SN - 0724-6145

    ER -