Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons

Sachin P. Patil, Nhung Tran, Hirosha Geekiyanage, Li Liu, Christina Chan

Research output: Contribution to journalArticle

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Abstract

Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by extracellular deposits of amyloid beta (Aβ) protein and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. Various studies suggest that the tau tangle pathology, which lies downstream to Aβ pathology, is essential to produce AD-associated clinical phenotype and thus treatments targeting tau pathology may prevent or delay disease progression effectively. In this context, our present study examined three polyphenol compounds (curcumin, EGCG and resveratrol) for their possible activity against two endogenous proteins (BAG2 and LAMP1) that are shown to play a vital role in clearing tau tangles from neurons. Human epidemiological and animal data suggest potential positive effects of these polyphenols against AD. Here, primary rat cortical neurons treated with these polyphenols significantly up-regulated BAG2 levels at different concentrations, while only EGCG upregulated LAMP1 levels, although at higher concentrations. Importantly, curcumin doubled BAG2 levels at low micromolar concentrations that are clinically relevant. In addition, curcumin also downregulated levels of phosphorylated tau, which may be potentially attributed to the curcumin-induced upregulation in BAG2 levels in the neurons. The present results demonstrate novel activity of polyphenol curcumin in up-regulating an anti-tau cochaperone BAG2 and thus, suggest probable benefit of curcumin against AD-associated tauopathy.

LanguageEnglish (US)
Pages121-125
Number of pages5
JournalNeuroscience Letters
Volume554
DOIs
StatePublished - Oct 25 2013

Profile

Curcumin
Up-Regulation
Polyphenols
Neurons
Alzheimer Disease
Pathology
Lysosomal-Associated Membrane Protein 1
Tauopathies
tau Proteins
Neurofibrillary Tangles
Amyloid beta-Peptides
Neurodegenerative Diseases
Disease Progression
Down-Regulation
Phenotype

Keywords

  • Alzheimer's disease
  • BAG2
  • Curcumin
  • Polyphenol
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons. / Patil, Sachin P.; Tran, Nhung; Geekiyanage, Hirosha; Liu, Li; Chan, Christina.

In: Neuroscience Letters, Vol. 554, 25.10.2013, p. 121-125.

Research output: Contribution to journalArticle

Patil, Sachin P. ; Tran, Nhung ; Geekiyanage, Hirosha ; Liu, Li ; Chan, Christina. / Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons. In: Neuroscience Letters. 2013 ; Vol. 554. pp. 121-125
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