Data-guided growth and remodeling model of abdominal aortic aneurysm accounting for the bio-chemical effects of intraluminal thrombus

Mehdi Farsad, Byron A. Zambrano, Seungik Baek

    Research output: Chapter in Book/Report/Conference proceedingChapter

    • 2 Citations

    Abstract

    Most of the abdominal aortic aneurysms (AAA) include an intraluminal thrombus (ILT) deposited on their internal wall. Active proteolytic enzymes in the ILT may cause bio-chemically weakening the aneurysmal wall, which leads to elevation of the aneurysm rupture risk. On the other hand, lack of oxygen on the aneurysmal wall beneath a thick ILT (hypoxia) causes proteolytic activity on the wall as a secondary effect. In this paper we develop an axisymmetric growth and remodeling model of the AAA considering the bio-chemical effects of the ILT mentioned above. We then estimate the model parameters using nine patients longitudinal CT data. The parametric study shows that AAA's radius and volume increases significantly in existence of ILT because of both hypoxia and proteolytic activity. However, the relation between the AAA volume and its maximum diameter slightly changes due to hypoxia while this relation highly changes because of the proteolytic activity in the luminal layer of the ILT. We also show that our numerical results for the AAA expansion as a function of its maximum diameter can be very close to the clinical data with a proper estimation of the model parameters.

    Original languageEnglish (US)
    Title of host publicationComputational Biomechanics for Medicine: New Approaches and New Applications
    PublisherSpringer International Publishing
    Pages13-23
    Number of pages11
    ISBN (Print)9783319155036, 9783319155029
    DOIs
    StatePublished - Jan 1 2015

    Profile

    Abdominal Aortic Aneurysm
    Thrombosis
    Anthralin
    hypoxia
    Anoxia
    chemical effects
    causes
    Erythrasma
    Alcuronium
    enzymes
    radii
    expansion
    oxygen
    estimates
    Saimiriine herpesvirus 2
    Hypopharyngeal Neoplasms
    Oxygen
    Aneurysm
    Rupture
    Peptide Hydrolases

    ASJC Scopus subject areas

    • Engineering(all)
    • Medicine(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Physics and Astronomy(all)
    • Computer Science(all)
    • Materials Science(all)

    Cite this

    Farsad, M., Zambrano, B. A., & Baek, S. (2015). Data-guided growth and remodeling model of abdominal aortic aneurysm accounting for the bio-chemical effects of intraluminal thrombus. In Computational Biomechanics for Medicine: New Approaches and New Applications (pp. 13-23). Springer International Publishing. DOI: 10.1007/978-3-319-15503-6_2

    Data-guided growth and remodeling model of abdominal aortic aneurysm accounting for the bio-chemical effects of intraluminal thrombus. / Farsad, Mehdi; Zambrano, Byron A.; Baek, Seungik.

    Computational Biomechanics for Medicine: New Approaches and New Applications. Springer International Publishing, 2015. p. 13-23.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Farsad, M, Zambrano, BA & Baek, S 2015, Data-guided growth and remodeling model of abdominal aortic aneurysm accounting for the bio-chemical effects of intraluminal thrombus. in Computational Biomechanics for Medicine: New Approaches and New Applications. Springer International Publishing, pp. 13-23. DOI: 10.1007/978-3-319-15503-6_2
    Farsad M, Zambrano BA, Baek S. Data-guided growth and remodeling model of abdominal aortic aneurysm accounting for the bio-chemical effects of intraluminal thrombus. In Computational Biomechanics for Medicine: New Approaches and New Applications. Springer International Publishing. 2015. p. 13-23. Available from, DOI: 10.1007/978-3-319-15503-6_2

    Farsad, Mehdi; Zambrano, Byron A.; Baek, Seungik / Data-guided growth and remodeling model of abdominal aortic aneurysm accounting for the bio-chemical effects of intraluminal thrombus.

    Computational Biomechanics for Medicine: New Approaches and New Applications. Springer International Publishing, 2015. p. 13-23.

    Research output: Chapter in Book/Report/Conference proceedingChapter

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