Deciphering metabolic rewiring in breast cancer subtypes

Martin P. Ogrodzinski, Jamie J. Bernard, Sophia Y. Lunt

Research output: Research - peer-reviewArticle

Abstract

Metabolic reprogramming, an emerging hallmark of cancer, is observed in breast cancer. Breast cancer cells rewire their cellular metabolism to meet the demands of survival, proliferation, and invasion. However, breast cancer is a heterogeneous disease, and metabolic rewiring is not uniform. Each subtype of breast cancer displays distinct metabolic alterations. Here, we focus on unique metabolic reprogramming associated with subtypes of breast cancer, as well as common features. Therapeutic opportunities based on subtype-specific metabolic alterations are also discussed. Through this discussion, we aim to provide insight into subtype-specific metabolic rewiring and vulnerabilities that have the potential to better guide therapy and improve outcomes for patients.

LanguageEnglish (US)
JournalTranslational Research
DOIs
StateAccepted/In press - 2017

Profile

Metabolism
Cells
Breast Neoplasms
Therapeutics
Metabolic Diseases
Survival
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical

Cite this

Deciphering metabolic rewiring in breast cancer subtypes. / Ogrodzinski, Martin P.; Bernard, Jamie J.; Lunt, Sophia Y.

In: Translational Research, 2017.

Research output: Research - peer-reviewArticle

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