Deciphering metabolic rewiring in breast cancer subtypes

Martin P. Ogrodzinski, Jamie J. Bernard, Sophia Y. Lunt

Research output: Contribution to journalArticle

Abstract

Metabolic reprogramming, an emerging hallmark of cancer, is observed in breast cancer. Breast cancer cells rewire their cellular metabolism to meet the demands of survival, proliferation, and invasion. However, breast cancer is a heterogeneous disease, and metabolic rewiring is not uniform. Each subtype of breast cancer displays distinct metabolic alterations. Here, we focus on unique metabolic reprogramming associated with subtypes of breast cancer, as well as common features. Therapeutic opportunities based on subtype-specific metabolic alterations are also discussed. Through this discussion, we aim to provide insight into subtype-specific metabolic rewiring and vulnerabilities that have the potential to better guide therapy and improve outcomes for patients.

Original languageEnglish (US)
JournalTranslational Research
DOIs
StateAccepted/In press - 2017

Profile

Supravalvular Aortic Stenosis
Castration
Metabolism
Breast Neoplasms
Metabolic Diseases
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical

Cite this

Deciphering metabolic rewiring in breast cancer subtypes. / Ogrodzinski, Martin P.; Bernard, Jamie J.; Lunt, Sophia Y.

In: Translational Research, 2017.

Research output: Contribution to journalArticle

Ogrodzinski, Martin P.; Bernard, Jamie J.; Lunt, Sophia Y. / Deciphering metabolic rewiring in breast cancer subtypes.

In: Translational Research, 2017.

Research output: Contribution to journalArticle

@article{faf914cd6fe64f429442ce0cb72ef580,
title = "Deciphering metabolic rewiring in breast cancer subtypes",
abstract = "Metabolic reprogramming, an emerging hallmark of cancer, is observed in breast cancer. Breast cancer cells rewire their cellular metabolism to meet the demands of survival, proliferation, and invasion. However, breast cancer is a heterogeneous disease, and metabolic rewiring is not uniform. Each subtype of breast cancer displays distinct metabolic alterations. Here, we focus on unique metabolic reprogramming associated with subtypes of breast cancer, as well as common features. Therapeutic opportunities based on subtype-specific metabolic alterations are also discussed. Through this discussion, we aim to provide insight into subtype-specific metabolic rewiring and vulnerabilities that have the potential to better guide therapy and improve outcomes for patients.",
author = "Ogrodzinski, {Martin P.} and Bernard, {Jamie J.} and Lunt, {Sophia Y.}",
year = "2017",
doi = "10.1016/j.trsl.2017.07.004",
journal = "Translational Research",
issn = "1931-5244",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Deciphering metabolic rewiring in breast cancer subtypes

AU - Ogrodzinski,Martin P.

AU - Bernard,Jamie J.

AU - Lunt,Sophia Y.

PY - 2017

Y1 - 2017

N2 - Metabolic reprogramming, an emerging hallmark of cancer, is observed in breast cancer. Breast cancer cells rewire their cellular metabolism to meet the demands of survival, proliferation, and invasion. However, breast cancer is a heterogeneous disease, and metabolic rewiring is not uniform. Each subtype of breast cancer displays distinct metabolic alterations. Here, we focus on unique metabolic reprogramming associated with subtypes of breast cancer, as well as common features. Therapeutic opportunities based on subtype-specific metabolic alterations are also discussed. Through this discussion, we aim to provide insight into subtype-specific metabolic rewiring and vulnerabilities that have the potential to better guide therapy and improve outcomes for patients.

AB - Metabolic reprogramming, an emerging hallmark of cancer, is observed in breast cancer. Breast cancer cells rewire their cellular metabolism to meet the demands of survival, proliferation, and invasion. However, breast cancer is a heterogeneous disease, and metabolic rewiring is not uniform. Each subtype of breast cancer displays distinct metabolic alterations. Here, we focus on unique metabolic reprogramming associated with subtypes of breast cancer, as well as common features. Therapeutic opportunities based on subtype-specific metabolic alterations are also discussed. Through this discussion, we aim to provide insight into subtype-specific metabolic rewiring and vulnerabilities that have the potential to better guide therapy and improve outcomes for patients.

UR - http://www.scopus.com/inward/record.url?scp=85027116376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027116376&partnerID=8YFLogxK

U2 - 10.1016/j.trsl.2017.07.004

DO - 10.1016/j.trsl.2017.07.004

M3 - Article

JO - Translational Research

T2 - Translational Research

JF - Translational Research

SN - 1931-5244

ER -