Detection of the anoxic depolarization of focal ischemia using Manganese-enhanced MRI

Ichio Aoki, Toshihiko Ebisu, Chuzo Tanaka, Kiyotaka Katsuta, Akihiko Fujikawa, Masahiro Umeda, Masaki Fukunaga, Tetsuro Takegami, Erik M. Shapiro, Shoji Naruse

Research output: Research - peer-reviewArticle

  • 41 Citations

Abstract

Mismatch between diffusion- and perfusion-weighted MRI was used to indicate a treatable area following focal ischemia, called the penumbra. Activity-induced manganese contrast MRI has been reported as a new visualization method for neural activation using manganese ions as a depolarization-dependent contrast agent. It is well known that energy failure induced by cerebral ischemia produces anoxic depolarization. The purpose of this study was to detect manganese accumulation caused by permanent middle cerebral artery occlusion (MCAO) of rat brain and to compare regional differences between manganese accumulation and decreased apparent diffusion coefficient (ADC). The ratios of signal intensity of manganese-enhanced MRI in the ipsilateral cortex to that in the contralateral cortex were 171.0 ± 17.5% in MCAO group and 108.4 ± 13.2% in the sham group. In addition, the enhanced region was much smaller than the area which was detected as having a reduced ADC.

LanguageEnglish (US)
Pages7-12
Number of pages6
JournalMagnetic Resonance in Medicine
Volume50
Issue number1
DOIs
StatePublished - Jul 1 2003
Externally publishedYes

Profile

Manganese
Ischemia
Middle Cerebral Artery Infarction
Diffusion Magnetic Resonance Imaging
Magnetic Resonance Angiography
Brain Ischemia
Contrast Media
Ions
Brain

Keywords

  • Anoxic depolarization
  • Focal ischemia
  • Manganese enhanced MRI
  • Penumbra

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Aoki, I., Ebisu, T., Tanaka, C., Katsuta, K., Fujikawa, A., Umeda, M., ... Naruse, S. (2003). Detection of the anoxic depolarization of focal ischemia using Manganese-enhanced MRI. Magnetic Resonance in Medicine, 50(1), 7-12. DOI: 10.1002/mrm.10528

Detection of the anoxic depolarization of focal ischemia using Manganese-enhanced MRI. / Aoki, Ichio; Ebisu, Toshihiko; Tanaka, Chuzo; Katsuta, Kiyotaka; Fujikawa, Akihiko; Umeda, Masahiro; Fukunaga, Masaki; Takegami, Tetsuro; Shapiro, Erik M.; Naruse, Shoji.

In: Magnetic Resonance in Medicine, Vol. 50, No. 1, 01.07.2003, p. 7-12.

Research output: Research - peer-reviewArticle

Aoki, I, Ebisu, T, Tanaka, C, Katsuta, K, Fujikawa, A, Umeda, M, Fukunaga, M, Takegami, T, Shapiro, EM & Naruse, S 2003, 'Detection of the anoxic depolarization of focal ischemia using Manganese-enhanced MRI' Magnetic Resonance in Medicine, vol 50, no. 1, pp. 7-12. DOI: 10.1002/mrm.10528
Aoki I, Ebisu T, Tanaka C, Katsuta K, Fujikawa A, Umeda M et al. Detection of the anoxic depolarization of focal ischemia using Manganese-enhanced MRI. Magnetic Resonance in Medicine. 2003 Jul 1;50(1):7-12. Available from, DOI: 10.1002/mrm.10528
Aoki, Ichio ; Ebisu, Toshihiko ; Tanaka, Chuzo ; Katsuta, Kiyotaka ; Fujikawa, Akihiko ; Umeda, Masahiro ; Fukunaga, Masaki ; Takegami, Tetsuro ; Shapiro, Erik M. ; Naruse, Shoji. / Detection of the anoxic depolarization of focal ischemia using Manganese-enhanced MRI. In: Magnetic Resonance in Medicine. 2003 ; Vol. 50, No. 1. pp. 7-12
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