Dynamic encapsulation of hydrophilic nisin in hydrophobic poly (lactic acid) particles with controlled morphology by a single emulsion process

Shaowen Ji, Jue Lu, Zhiguo Liu, Devesh Srivastava, Anna Song, Yan Liu, Ilsoon Lee

    Research output: Contribution to journalArticle

    • 6 Citations

    Abstract

    Hydrophilic nisin-loaded hydrophobic poly (lactic acid) (PLA) particles with controlled size and shape were successfully produced utilizing a one-step single emulsification method. Preliminary shear stress and temperature tests showed that there was no significant loss in the nisin inhibition activity during this process. PLA/nisin composite particles were prepared into solid nanocomposite spheres (50-200. nm) or hollow microcomposite spheres (1-5. μm) under the operative conditions developed in our previous study, in which the hydrophilic nisin in the aqueous phase solution could be entrapped in the hydrophobic polymer in the emulsification process generating either single or multiple emulsions. The incorporation of nisin in PLA had little effect on key processing conditions, which allows the dynamic control of the morphology and property of resulting particles. Microscopic and surface analyses suggested that nisin was dispersed uniformly inside the polymer matrix and adsorbed on the particle surface. The encapsulation amount and efficiency were enhanced with the increase in nisin loading in the aqueous solution. Unique reversible control of particle size and shape by this process was successfully applied in the nisin encapsulation. Alternating temperature in the repeating emulsification steps improved the encapsulation efficiency while generated particles in desired size and shape.

    Original languageEnglish (US)
    Pages (from-to)85-93
    Number of pages9
    JournalJournal of Colloid and Interface Science
    Volume423
    DOIs
    StatePublished - Jun 1 2014

    Profile

    Encapsulation
    Nisin
    Emulsions
    Lactic Acid
    Emulsification
    Lactic acid
    Temperature
    Cardiac Catheterization
    Fallopian Tubes
    Polymer matrix
    Shear stress
    Nanocomposites
    Particle size
    Composite materials
    Polymers
    Edema Disease of Swine
    Acetanilides
    Fusobacterium
    Spontaneous Fractures
    Blood Flow Velocity

    Keywords

    • Emulsion process
    • Nisin encapsulation
    • PLA
    • Polymeric composites
    • Reversible morphology control

    ASJC Scopus subject areas

    • Surfaces, Coatings and Films
    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Colloid and Surface Chemistry
    • Medicine(all)

    Cite this

    Dynamic encapsulation of hydrophilic nisin in hydrophobic poly (lactic acid) particles with controlled morphology by a single emulsion process. / Ji, Shaowen; Lu, Jue; Liu, Zhiguo; Srivastava, Devesh; Song, Anna; Liu, Yan; Lee, Ilsoon.

    In: Journal of Colloid and Interface Science, Vol. 423, 01.06.2014, p. 85-93.

    Research output: Contribution to journalArticle

    Ji, Shaowen; Lu, Jue; Liu, Zhiguo; Srivastava, Devesh; Song, Anna; Liu, Yan; Lee, Ilsoon / Dynamic encapsulation of hydrophilic nisin in hydrophobic poly (lactic acid) particles with controlled morphology by a single emulsion process.

    In: Journal of Colloid and Interface Science, Vol. 423, 01.06.2014, p. 85-93.

    Research output: Contribution to journalArticle

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    abstract = "Hydrophilic nisin-loaded hydrophobic poly (lactic acid) (PLA) particles with controlled size and shape were successfully produced utilizing a one-step single emulsification method. Preliminary shear stress and temperature tests showed that there was no significant loss in the nisin inhibition activity during this process. PLA/nisin composite particles were prepared into solid nanocomposite spheres (50-200. nm) or hollow microcomposite spheres (1-5. μm) under the operative conditions developed in our previous study, in which the hydrophilic nisin in the aqueous phase solution could be entrapped in the hydrophobic polymer in the emulsification process generating either single or multiple emulsions. The incorporation of nisin in PLA had little effect on key processing conditions, which allows the dynamic control of the morphology and property of resulting particles. Microscopic and surface analyses suggested that nisin was dispersed uniformly inside the polymer matrix and adsorbed on the particle surface. The encapsulation amount and efficiency were enhanced with the increase in nisin loading in the aqueous solution. Unique reversible control of particle size and shape by this process was successfully applied in the nisin encapsulation. Alternating temperature in the repeating emulsification steps improved the encapsulation efficiency while generated particles in desired size and shape.",
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    AU - Liu,Yan

    AU - Lee,Ilsoon

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