Encapsulation of hydrophobic or hydrophilic iron oxide nanoparticles into poly-(lactic acid) micro/nanoparticles via adaptable emulsion setup

Anna Song, Shaowen Ji, Joung Sook Hong, Yi Ji, Ankush A. Gokhale, Ilsoon Lee

Research output: Contribution to journalArticle

Abstract

In this study, a one-step water-in-oil-in-water (W/O/W) emulsion process was employed to encapsulate either hydrophilic (∼10 nm) or hydrophobic (∼5 nm) iron oxide nanoparticles (IONPs) into poly(lactic acid) (PLA). Via the simple adjustment of emulsification temperature to high temperature (HT, 60°C) or room temperature (RT, 25°C), a transformation of PLA-IONPs composite particles from hollow microparticles to solid nanospheres can be achieved. At RT, PLA nanocomposite particles (30-200 nm) encapsulating IONPs were generated regardless of the hydrophobicity of IONPs. On the other hand, at HT, our method resulted in the hollow microparticles (2-5 μm). This study presents a fast and easily adaptable process to encapsulate either hydrophobic or hydrophilic IONPs into the hydrophobic polymeric particles, with different shapes and sizes, by simply adjusting the emulsification temperature through the one-step W/O/W emulsion.

Original languageEnglish (US)
JournalJournal of Applied Polymer Science
DOIs
StateAccepted/In press - 2016

Profile

Nanoparticles
Myosins
Iron oxides
Lactic acid
Water
Temperature
Acetanilides
Emulsions
Emulsification
Fallopian Tubes
Nanospheres
Hydrophobicity
Encapsulation
Nanocomposites
Composite materials
Immunoglobulin Allotypes
Laryngeal Mucosa
Butylene Glycols
Asbestos
Cardiac Catheterization

Keywords

  • Applications
  • Biodegradable
  • Composites
  • Magnetic nanoparticles
  • Nanoparticles
  • Poly(lactic acid)

ASJC Scopus subject areas

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Encapsulation of hydrophobic or hydrophilic iron oxide nanoparticles into poly-(lactic acid) micro/nanoparticles via adaptable emulsion setup. / Song, Anna; Ji, Shaowen; Sook Hong, Joung; Ji, Yi; Gokhale, Ankush A.; Lee, Ilsoon.

In: Journal of Applied Polymer Science, 2016.

Research output: Contribution to journalArticle

Song, Anna; Ji, Shaowen; Sook Hong, Joung; Ji, Yi; Gokhale, Ankush A.; Lee, Ilsoon / Encapsulation of hydrophobic or hydrophilic iron oxide nanoparticles into poly-(lactic acid) micro/nanoparticles via adaptable emulsion setup.

In: Journal of Applied Polymer Science, 2016.

Research output: Contribution to journalArticle

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AU - Gokhale,Ankush A.

AU - Lee,Ilsoon

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