Encapsulation of hydrophobic or hydrophilic iron oxide nanoparticles into poly-(lactic acid) micro/nanoparticles via adaptable emulsion setup

Anna Song, Shaowen Ji, Joung Sook Hong, Yi Ji, Ankush A. Gokhale, Ilsoon Lee

Research output: Research - peer-reviewArticle

Abstract

In this study, a one-step water-in-oil-in-water (W/O/W) emulsion process was employed to encapsulate either hydrophilic (∼10 nm) or hydrophobic (∼5 nm) iron oxide nanoparticles (IONPs) into poly(lactic acid) (PLA). Via the simple adjustment of emulsification temperature to high temperature (HT, 60°C) or room temperature (RT, 25°C), a transformation of PLA-IONPs composite particles from hollow microparticles to solid nanospheres can be achieved. At RT, PLA nanocomposite particles (30-200 nm) encapsulating IONPs were generated regardless of the hydrophobicity of IONPs. On the other hand, at HT, our method resulted in the hollow microparticles (2-5 μm). This study presents a fast and easily adaptable process to encapsulate either hydrophobic or hydrophilic IONPs into the hydrophobic polymeric particles, with different shapes and sizes, by simply adjusting the emulsification temperature through the one-step W/O/W emulsion.

LanguageEnglish (US)
JournalJournal of Applied Polymer Science
DOIs
StateAccepted/In press - 2016

Profile

Lactic acid
Iron oxides
Encapsulation
Emulsions
Nanoparticles
poly(lactic acid)
ferric oxide
Water
Temperature
Emulsification
Oils
Nanospheres
Hydrophobicity
Nanocomposites
Composite materials

Keywords

  • Applications
  • Biodegradable
  • Composites
  • Magnetic nanoparticles
  • Nanoparticles
  • Poly(lactic acid)

ASJC Scopus subject areas

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Encapsulation of hydrophobic or hydrophilic iron oxide nanoparticles into poly-(lactic acid) micro/nanoparticles via adaptable emulsion setup. / Song, Anna; Ji, Shaowen; Sook Hong, Joung; Ji, Yi; Gokhale, Ankush A.; Lee, Ilsoon.

In: Journal of Applied Polymer Science, 2016.

Research output: Research - peer-reviewArticle

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AU - Sook Hong,Joung

AU - Ji,Yi

AU - Gokhale,Ankush A.

AU - Lee,Ilsoon

PY - 2016

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N2 - In this study, a one-step water-in-oil-in-water (W/O/W) emulsion process was employed to encapsulate either hydrophilic (∼10 nm) or hydrophobic (∼5 nm) iron oxide nanoparticles (IONPs) into poly(lactic acid) (PLA). Via the simple adjustment of emulsification temperature to high temperature (HT, 60°C) or room temperature (RT, 25°C), a transformation of PLA-IONPs composite particles from hollow microparticles to solid nanospheres can be achieved. At RT, PLA nanocomposite particles (30-200 nm) encapsulating IONPs were generated regardless of the hydrophobicity of IONPs. On the other hand, at HT, our method resulted in the hollow microparticles (2-5 μm). This study presents a fast and easily adaptable process to encapsulate either hydrophobic or hydrophilic IONPs into the hydrophobic polymeric particles, with different shapes and sizes, by simply adjusting the emulsification temperature through the one-step W/O/W emulsion.

AB - In this study, a one-step water-in-oil-in-water (W/O/W) emulsion process was employed to encapsulate either hydrophilic (∼10 nm) or hydrophobic (∼5 nm) iron oxide nanoparticles (IONPs) into poly(lactic acid) (PLA). Via the simple adjustment of emulsification temperature to high temperature (HT, 60°C) or room temperature (RT, 25°C), a transformation of PLA-IONPs composite particles from hollow microparticles to solid nanospheres can be achieved. At RT, PLA nanocomposite particles (30-200 nm) encapsulating IONPs were generated regardless of the hydrophobicity of IONPs. On the other hand, at HT, our method resulted in the hollow microparticles (2-5 μm). This study presents a fast and easily adaptable process to encapsulate either hydrophobic or hydrophilic IONPs into the hydrophobic polymeric particles, with different shapes and sizes, by simply adjusting the emulsification temperature through the one-step W/O/W emulsion.

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