Gene module level analysis: identification to networks and dynamics

Xuewei Wang, Ertugrul Dalkic, Ming Wu, Christina Chan

Research output: Contribution to journalArticle

  • 60 Citations

Abstract

Nature exhibits modular design in biological systems. Gene module level analysis is based on this module concept, aiming to understand biological network design and systems behavior in disease and development by emphasizing on modules of genes rather than individual genes. Module level analysis has been extensively applied in genome wide level analysis, exploring the organization of biological systems from identifying modules to reconstructing module networks and analyzing module dynamics. Such module level perspective provides a high level representation of the regulatory scenario and design of biological systems, promising to revolutionize our view of systems biology, genetic engineering as well as disease mechanisms and molecular medicine.

LanguageEnglish (US)
Pages482-491
Number of pages10
JournalCurrent Opinion in Biotechnology
Volume19
Issue number5
DOIs
StatePublished - Oct 2008

Profile

Gene Regulatory Networks
Biological systems
Genes
Molecular Medicine
Inborn Genetic Diseases
Genetic Engineering
Systems Biology
Genome
Genetic engineering
Medicine

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Gene module level analysis : identification to networks and dynamics. / Wang, Xuewei; Dalkic, Ertugrul; Wu, Ming; Chan, Christina.

In: Current Opinion in Biotechnology, Vol. 19, No. 5, 10.2008, p. 482-491.

Research output: Contribution to journalArticle

Wang, Xuewei ; Dalkic, Ertugrul ; Wu, Ming ; Chan, Christina. / Gene module level analysis : identification to networks and dynamics. In: Current Opinion in Biotechnology. 2008 ; Vol. 19, No. 5. pp. 482-491
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