Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies

Christina Chan, François Berthiaume, Bharath D. Nath, Arno W. Tilles, Mehmet Toner, Martin L. Yarmush

    Research output: Research - peer-reviewArticle

    • 92 Citations

    Abstract

    The severe donor liver shortage, high cost, and complexity of orthotopic liver transplantation have prompted the search for alternative treatment strategies for end-stage liver disease, which would require less donor material, be cheaper, and less invasive. Hepatic tissue engineering encompasses several approaches to develop adjunct internal liver support methods, such as heparocyte transplantation and implantable hepatocyte-based devices, as well as temporary extracorporeal liver support techniques, such as bioartificial liver assist devices. Many tissue engineered liver support systems have passed the "proof of principle" test in preclinical and clinical studies; however, they have not yet been found sufficiently reliably effective for routine clinical use. In this review we describe, from an engineering perspective, the progress and remaining challenges that must be resolved in order to develop the next generation of implantable and extracorporeal devices for adjunct or temporary liver assist.

    LanguageEnglish (US)
    Pages1331-1342
    Number of pages12
    JournalLiver Transplantation
    Volume10
    Issue number11
    DOIs
    StatePublished - Nov 2004

    Profile

    Tissue Engineering
    Technology
    Liver
    Equipment and Supplies
    Artificial Liver
    End Stage Liver Disease
    Liver Transplantation
    Hepatocytes
    Transplantation
    Costs and Cost Analysis
    Therapeutics
    Clinical Studies

    ASJC Scopus subject areas

    • Surgery
    • Transplantation

    Cite this

    Chan, C., Berthiaume, F., Nath, B. D., Tilles, A. W., Toner, M., & Yarmush, M. L. (2004). Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies. Liver Transplantation, 10(11), 1331-1342. DOI: 10.1002/lt.20229

    Hepatic tissue engineering for adjunct and temporary liver support : Critical technologies. / Chan, Christina; Berthiaume, François; Nath, Bharath D.; Tilles, Arno W.; Toner, Mehmet; Yarmush, Martin L.

    In: Liver Transplantation, Vol. 10, No. 11, 11.2004, p. 1331-1342.

    Research output: Research - peer-reviewArticle

    Chan, C, Berthiaume, F, Nath, BD, Tilles, AW, Toner, M & Yarmush, ML 2004, 'Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies' Liver Transplantation, vol 10, no. 11, pp. 1331-1342. DOI: 10.1002/lt.20229
    Chan C, Berthiaume F, Nath BD, Tilles AW, Toner M, Yarmush ML. Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies. Liver Transplantation. 2004 Nov;10(11):1331-1342. Available from, DOI: 10.1002/lt.20229
    Chan, Christina ; Berthiaume, François ; Nath, Bharath D. ; Tilles, Arno W. ; Toner, Mehmet ; Yarmush, Martin L./ Hepatic tissue engineering for adjunct and temporary liver support : Critical technologies. In: Liver Transplantation. 2004 ; Vol. 10, No. 11. pp. 1331-1342
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