Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies

Christina Chan, François Berthiaume, Bharath D. Nath, Arno W. Tilles, Mehmet Toner, Martin L. Yarmush

Research output: Contribution to journalArticle

  • 95 Citations

Abstract

The severe donor liver shortage, high cost, and complexity of orthotopic liver transplantation have prompted the search for alternative treatment strategies for end-stage liver disease, which would require less donor material, be cheaper, and less invasive. Hepatic tissue engineering encompasses several approaches to develop adjunct internal liver support methods, such as heparocyte transplantation and implantable hepatocyte-based devices, as well as temporary extracorporeal liver support techniques, such as bioartificial liver assist devices. Many tissue engineered liver support systems have passed the "proof of principle" test in preclinical and clinical studies; however, they have not yet been found sufficiently reliably effective for routine clinical use. In this review we describe, from an engineering perspective, the progress and remaining challenges that must be resolved in order to develop the next generation of implantable and extracorporeal devices for adjunct or temporary liver assist.

LanguageEnglish (US)
Pages1331-1342
Number of pages12
JournalLiver Transplantation
Volume10
Issue number11
DOIs
StatePublished - Nov 2004

Profile

Tissue Engineering
Technology
Liver
Equipment and Supplies
Artificial Liver
End Stage Liver Disease
Liver Transplantation
Hepatocytes
Transplantation
Costs and Cost Analysis

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Chan, C., Berthiaume, F., Nath, B. D., Tilles, A. W., Toner, M., & Yarmush, M. L. (2004). Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies. Liver Transplantation, 10(11), 1331-1342. DOI: 10.1002/lt.20229

Hepatic tissue engineering for adjunct and temporary liver support : Critical technologies. / Chan, Christina; Berthiaume, François; Nath, Bharath D.; Tilles, Arno W.; Toner, Mehmet; Yarmush, Martin L.

In: Liver Transplantation, Vol. 10, No. 11, 11.2004, p. 1331-1342.

Research output: Contribution to journalArticle

Chan, C, Berthiaume, F, Nath, BD, Tilles, AW, Toner, M & Yarmush, ML 2004, 'Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies' Liver Transplantation, vol 10, no. 11, pp. 1331-1342. DOI: 10.1002/lt.20229
Chan C, Berthiaume F, Nath BD, Tilles AW, Toner M, Yarmush ML. Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies. Liver Transplantation. 2004 Nov;10(11):1331-1342. Available from, DOI: 10.1002/lt.20229
Chan, Christina ; Berthiaume, François ; Nath, Bharath D. ; Tilles, Arno W. ; Toner, Mehmet ; Yarmush, Martin L./ Hepatic tissue engineering for adjunct and temporary liver support : Critical technologies. In: Liver Transplantation. 2004 ; Vol. 10, No. 11. pp. 1331-1342
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