Hydrogenation of amino acid mixtures to amino alcohols

Ketan P. Pimparkar, Dennis J. Miller, James E. Jackson

Research output: Contribution to journalArticle

  • 13 Citations

Abstract

Amino alcohols are important building blocks for a variety of pharmaceutical, insecticidal, and other specialty compounds. Hydrogenation of amino acids to amino alcohols is a route that allows for the incorporation of biorenewable-derived chemicals into traditional petroleum-based industrial processes. This study examines the effect of multiple substrates on aqueous-phase hydrogenation rates of the amino acids serine, alanine, and valine. Hydrogenation reactions were carried out in a high-pressure reactor at 7.0 MPa hydrogen pressure and 130°C over carbon supported ruthenium catalyst. Samples taken at regular intervals and analyzed by high-performance liquid chromatography allowed calculation of conversion rates and product yields. In general, competition between the amino acid substrates results in reduced reaction rates relative to that for hydrogenation of a single amino acid substrate. Kinetics of mixed amino acid hydrogenation was modeled using a Langmuir-Hinshelwood-type mechanism with surface reaction as the rate-limiting step.

LanguageEnglish (US)
Pages7648-7653
Number of pages6
JournalIndustrial and Engineering Chemistry Research
Volume47
Issue number20
DOIs
StatePublished - Oct 15 2008

Profile

Amino alcohols
Amino Alcohols
Hydrogenation
Amino acids
Amino Acids
Substrates
Ruthenium
Petroleum
Valine
Surface reactions
High performance liquid chromatography
Alanine
Drug products
Serine
Reaction rates
Hydrogen
Carbon
Crude oil
Catalysts
Kinetics

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Industrial and Manufacturing Engineering

Cite this

Hydrogenation of amino acid mixtures to amino alcohols. / Pimparkar, Ketan P.; Miller, Dennis J.; Jackson, James E.

In: Industrial and Engineering Chemistry Research, Vol. 47, No. 20, 15.10.2008, p. 7648-7653.

Research output: Contribution to journalArticle

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