Hydrogenation of amino acid mixtures to amino alcohols

Ketan P. Pimparkar, Dennis J. Miller, James E. Jackson

    Research output: Contribution to journalArticle

    • 11 Citations

    Abstract

    Amino alcohols are important building blocks for a variety of pharmaceutical, insecticidal, and other specialty compounds. Hydrogenation of amino acids to amino alcohols is a route that allows for the incorporation of biorenewable-derived chemicals into traditional petroleum-based industrial processes. This study examines the effect of multiple substrates on aqueous-phase hydrogenation rates of the amino acids serine, alanine, and valine. Hydrogenation reactions were carried out in a high-pressure reactor at 7.0 MPa hydrogen pressure and 130°C over carbon supported ruthenium catalyst. Samples taken at regular intervals and analyzed by high-performance liquid chromatography allowed calculation of conversion rates and product yields. In general, competition between the amino acid substrates results in reduced reaction rates relative to that for hydrogenation of a single amino acid substrate. Kinetics of mixed amino acid hydrogenation was modeled using a Langmuir-Hinshelwood-type mechanism with surface reaction as the rate-limiting step.

    Original languageEnglish (US)
    Pages (from-to)7648-7653
    Number of pages6
    JournalIndustrial and Engineering Chemistry Research
    Volume47
    Issue number20
    DOIs
    StatePublished - Oct 15 2008

    Profile

    Hydrogenation
    Amino acids
    Amino Alcohols
    Amino Acids
    Deoxyribonucleoproteins
    Amino alcohols
    Substrates
    Biogenic Amines
    Ruthenium
    Petroleum
    Valine
    Alanine
    Serine
    Hydrogen
    Carbon
    High Pressure Liquid Chromatography
    Surface reactions
    High performance liquid chromatography
    Drug products
    Reaction rates

    ASJC Scopus subject areas

    • Chemical Engineering(all)
    • Chemistry(all)
    • Industrial and Manufacturing Engineering

    Cite this

    Hydrogenation of amino acid mixtures to amino alcohols. / Pimparkar, Ketan P.; Miller, Dennis J.; Jackson, James E.

    In: Industrial and Engineering Chemistry Research, Vol. 47, No. 20, 15.10.2008, p. 7648-7653.

    Research output: Contribution to journalArticle

    Pimparkar, Ketan P.; Miller, Dennis J.; Jackson, James E. / Hydrogenation of amino acid mixtures to amino alcohols.

    In: Industrial and Engineering Chemistry Research, Vol. 47, No. 20, 15.10.2008, p. 7648-7653.

    Research output: Contribution to journalArticle

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