Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic FexCo1-xFe2O4 nanoensembles

S. Manjura Hoque, Yuegao Huang, Emiliano Cocco, Samuel Maritim, Alessandro D. Santin, Erik M. Shapiro, Daniel Coman, Fahmeed Hyder

Research output: Contribution to journalArticle

  • 4 Citations

Abstract

Ferrite-based ferri/superparamagnetic nanoparticles can be rapidly heated by an external alternating magnetic field (AMF) to induce tissue necrosis of the adjacent microenvironment, but in addition provide magnetic resonance imaging (MRI) contrast utilizing enhanced water relaxivity. Here we characterized nanoensembles of Fe-Co mixed spinel ferrites (i.e. FexCo1-xFe2O4, where x ranges from 0.2 to 0.8) synthesized by chemical co-precipitation. With nanoensembles of increasing Co content the saturation magnetization improved, while lattice parameter remained relatively constant. MRI water (transverse) relaxivity at 11.7T was also boosted with increasing Co content. Efficiency of AMF-induced heating was quite comparable for the nanoensembles with either chitosan or polyethylene glycol (PEG) coating except for PEG-coated Fe0.2Co0.8Fe2O4, which was twice as less efficient as others. While toxicity of the nanoensembles with either coating examined on 9L tumor cell cultures showed no significant differences, upon AMF exposure (i.e. heat-induced necrosis) FexCo1-xFe2O4 composition with different values of x showed quite dramatic effects on cell death of tumor cells with both coatings. This study lays the ground work for further characterization of other mixed spinel ferrites, and in addition we expect that chitosan and PEG coated FexCo1-xFe2O4 of all the compositions will have good potential for preclinical applications in vivo.

LanguageEnglish (US)
JournalContrast Media and Molecular Imaging
DOIs
StateAccepted/In press - 2016

Profile

Magnetic Fields
Fever
Magnetic Resonance Imaging
Chitosan
Chemical Precipitation
Necrosis
Neoplasms
Water
Nanoparticles
Heating
Cell Death
Cell Culture Techniques
Hot Temperature
ferrite
spinell

Keywords

  • 9L gliosarcoma cells
  • Chitosan
  • Hydrophilic
  • MRI contrast agent
  • Nanoensembles
  • Nuclear magnetic resonance
  • PEG
  • Specific loss power

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic FexCo1-xFe2O4 nanoensembles. / Hoque, S. Manjura; Huang, Yuegao; Cocco, Emiliano; Maritim, Samuel; Santin, Alessandro D.; Shapiro, Erik M.; Coman, Daniel; Hyder, Fahmeed.

In: Contrast Media and Molecular Imaging, 2016.

Research output: Contribution to journalArticle

Hoque, S. Manjura ; Huang, Yuegao ; Cocco, Emiliano ; Maritim, Samuel ; Santin, Alessandro D. ; Shapiro, Erik M. ; Coman, Daniel ; Hyder, Fahmeed. / Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic FexCo1-xFe2O4 nanoensembles. In: Contrast Media and Molecular Imaging. 2016
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AU - Cocco,Emiliano

AU - Maritim,Samuel

AU - Santin,Alessandro D.

AU - Shapiro,Erik M.

AU - Coman,Daniel

AU - Hyder,Fahmeed

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AB - Ferrite-based ferri/superparamagnetic nanoparticles can be rapidly heated by an external alternating magnetic field (AMF) to induce tissue necrosis of the adjacent microenvironment, but in addition provide magnetic resonance imaging (MRI) contrast utilizing enhanced water relaxivity. Here we characterized nanoensembles of Fe-Co mixed spinel ferrites (i.e. FexCo1-xFe2O4, where x ranges from 0.2 to 0.8) synthesized by chemical co-precipitation. With nanoensembles of increasing Co content the saturation magnetization improved, while lattice parameter remained relatively constant. MRI water (transverse) relaxivity at 11.7T was also boosted with increasing Co content. Efficiency of AMF-induced heating was quite comparable for the nanoensembles with either chitosan or polyethylene glycol (PEG) coating except for PEG-coated Fe0.2Co0.8Fe2O4, which was twice as less efficient as others. While toxicity of the nanoensembles with either coating examined on 9L tumor cell cultures showed no significant differences, upon AMF exposure (i.e. heat-induced necrosis) FexCo1-xFe2O4 composition with different values of x showed quite dramatic effects on cell death of tumor cells with both coatings. This study lays the ground work for further characterization of other mixed spinel ferrites, and in addition we expect that chitosan and PEG coated FexCo1-xFe2O4 of all the compositions will have good potential for preclinical applications in vivo.

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