Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic FexCo1-xFe2O4 nanoensembles

S. Manjura Hoque, Yuegao Huang, Emiliano Cocco, Samuel Maritim, Alessandro D. Santin, Erik M. Shapiro, Daniel Coman, Fahmeed Hyder

    Research output: Contribution to journalArticle

    Abstract

    Ferrite-based ferri/superparamagnetic nanoparticles can be rapidly heated by an external alternating magnetic field (AMF) to induce tissue necrosis of the adjacent microenvironment, but in addition provide magnetic resonance imaging (MRI) contrast utilizing enhanced water relaxivity. Here we characterized nanoensembles of Fe-Co mixed spinel ferrites (i.e. FexCo1-xFe2O4, where x ranges from 0.2 to 0.8) synthesized by chemical co-precipitation. With nanoensembles of increasing Co content the saturation magnetization improved, while lattice parameter remained relatively constant. MRI water (transverse) relaxivity at 11.7T was also boosted with increasing Co content. Efficiency of AMF-induced heating was quite comparable for the nanoensembles with either chitosan or polyethylene glycol (PEG) coating except for PEG-coated Fe0.2Co0.8Fe2O4, which was twice as less efficient as others. While toxicity of the nanoensembles with either coating examined on 9L tumor cell cultures showed no significant differences, upon AMF exposure (i.e. heat-induced necrosis) FexCo1-xFe2O4 composition with different values of x showed quite dramatic effects on cell death of tumor cells with both coatings. This study lays the ground work for further characterization of other mixed spinel ferrites, and in addition we expect that chitosan and PEG coated FexCo1-xFe2O4 of all the compositions will have good potential for preclinical applications in vivo.

    Original languageEnglish (US)
    JournalContrast Media and Molecular Imaging
    DOIs
    StateAccepted/In press - 2016

    Profile

    Magnetic Fields
    Fever
    Magnetic Resonance Imaging
    Neoplasms
    Chitosan
    Necrosis
    Water
    Chemical Precipitation
    Nanoparticles
    Heating
    Cell Death
    Cell Culture Techniques
    Hot Temperature

    Keywords

    • 9L gliosarcoma cells
    • Chitosan
    • Hydrophilic
    • MRI contrast agent
    • Nanoensembles
    • Nuclear magnetic resonance
    • PEG
    • Specific loss power

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic FexCo1-xFe2O4 nanoensembles. / Hoque, S. Manjura; Huang, Yuegao; Cocco, Emiliano; Maritim, Samuel; Santin, Alessandro D.; Shapiro, Erik M.; Coman, Daniel; Hyder, Fahmeed.

    In: Contrast Media and Molecular Imaging, 2016.

    Research output: Contribution to journalArticle

    Hoque, S. Manjura; Huang, Yuegao; Cocco, Emiliano; Maritim, Samuel; Santin, Alessandro D.; Shapiro, Erik M.; Coman, Daniel; Hyder, Fahmeed / Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic FexCo1-xFe2O4 nanoensembles.

    In: Contrast Media and Molecular Imaging, 2016.

    Research output: Contribution to journalArticle

    @article{16a6d4118d1147c38c178c13487ff42f,
    title = "Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic FexCo1-xFe2O4 nanoensembles",
    abstract = "Ferrite-based ferri/superparamagnetic nanoparticles can be rapidly heated by an external alternating magnetic field (AMF) to induce tissue necrosis of the adjacent microenvironment, but in addition provide magnetic resonance imaging (MRI) contrast utilizing enhanced water relaxivity. Here we characterized nanoensembles of Fe-Co mixed spinel ferrites (i.e. FexCo1-xFe2O4, where x ranges from 0.2 to 0.8) synthesized by chemical co-precipitation. With nanoensembles of increasing Co content the saturation magnetization improved, while lattice parameter remained relatively constant. MRI water (transverse) relaxivity at 11.7T was also boosted with increasing Co content. Efficiency of AMF-induced heating was quite comparable for the nanoensembles with either chitosan or polyethylene glycol (PEG) coating except for PEG-coated Fe0.2Co0.8Fe2O4, which was twice as less efficient as others. While toxicity of the nanoensembles with either coating examined on 9L tumor cell cultures showed no significant differences, upon AMF exposure (i.e. heat-induced necrosis) FexCo1-xFe2O4 composition with different values of x showed quite dramatic effects on cell death of tumor cells with both coatings. This study lays the ground work for further characterization of other mixed spinel ferrites, and in addition we expect that chitosan and PEG coated FexCo1-xFe2O4 of all the compositions will have good potential for preclinical applications in vivo.",
    keywords = "9L gliosarcoma cells, Chitosan, Hydrophilic, MRI contrast agent, Nanoensembles, Nuclear magnetic resonance, PEG, Specific loss power",
    author = "Hoque, {S. Manjura} and Yuegao Huang and Emiliano Cocco and Samuel Maritim and Santin, {Alessandro D.} and Shapiro, {Erik M.} and Daniel Coman and Fahmeed Hyder",
    year = "2016",
    doi = "10.1002/cmmi.1713",
    journal = "Contrast Media and Molecular Imaging",
    issn = "1555-4309",
    publisher = "John Wiley and Sons Ltd",

    }

    TY - JOUR

    T1 - Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic FexCo1-xFe2O4 nanoensembles

    AU - Hoque,S. Manjura

    AU - Huang,Yuegao

    AU - Cocco,Emiliano

    AU - Maritim,Samuel

    AU - Santin,Alessandro D.

    AU - Shapiro,Erik M.

    AU - Coman,Daniel

    AU - Hyder,Fahmeed

    PY - 2016

    Y1 - 2016

    N2 - Ferrite-based ferri/superparamagnetic nanoparticles can be rapidly heated by an external alternating magnetic field (AMF) to induce tissue necrosis of the adjacent microenvironment, but in addition provide magnetic resonance imaging (MRI) contrast utilizing enhanced water relaxivity. Here we characterized nanoensembles of Fe-Co mixed spinel ferrites (i.e. FexCo1-xFe2O4, where x ranges from 0.2 to 0.8) synthesized by chemical co-precipitation. With nanoensembles of increasing Co content the saturation magnetization improved, while lattice parameter remained relatively constant. MRI water (transverse) relaxivity at 11.7T was also boosted with increasing Co content. Efficiency of AMF-induced heating was quite comparable for the nanoensembles with either chitosan or polyethylene glycol (PEG) coating except for PEG-coated Fe0.2Co0.8Fe2O4, which was twice as less efficient as others. While toxicity of the nanoensembles with either coating examined on 9L tumor cell cultures showed no significant differences, upon AMF exposure (i.e. heat-induced necrosis) FexCo1-xFe2O4 composition with different values of x showed quite dramatic effects on cell death of tumor cells with both coatings. This study lays the ground work for further characterization of other mixed spinel ferrites, and in addition we expect that chitosan and PEG coated FexCo1-xFe2O4 of all the compositions will have good potential for preclinical applications in vivo.

    AB - Ferrite-based ferri/superparamagnetic nanoparticles can be rapidly heated by an external alternating magnetic field (AMF) to induce tissue necrosis of the adjacent microenvironment, but in addition provide magnetic resonance imaging (MRI) contrast utilizing enhanced water relaxivity. Here we characterized nanoensembles of Fe-Co mixed spinel ferrites (i.e. FexCo1-xFe2O4, where x ranges from 0.2 to 0.8) synthesized by chemical co-precipitation. With nanoensembles of increasing Co content the saturation magnetization improved, while lattice parameter remained relatively constant. MRI water (transverse) relaxivity at 11.7T was also boosted with increasing Co content. Efficiency of AMF-induced heating was quite comparable for the nanoensembles with either chitosan or polyethylene glycol (PEG) coating except for PEG-coated Fe0.2Co0.8Fe2O4, which was twice as less efficient as others. While toxicity of the nanoensembles with either coating examined on 9L tumor cell cultures showed no significant differences, upon AMF exposure (i.e. heat-induced necrosis) FexCo1-xFe2O4 composition with different values of x showed quite dramatic effects on cell death of tumor cells with both coatings. This study lays the ground work for further characterization of other mixed spinel ferrites, and in addition we expect that chitosan and PEG coated FexCo1-xFe2O4 of all the compositions will have good potential for preclinical applications in vivo.

    KW - 9L gliosarcoma cells

    KW - Chitosan

    KW - Hydrophilic

    KW - MRI contrast agent

    KW - Nanoensembles

    KW - Nuclear magnetic resonance

    KW - PEG

    KW - Specific loss power

    UR - http://www.scopus.com/inward/record.url?scp=84988838310&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84988838310&partnerID=8YFLogxK

    U2 - 10.1002/cmmi.1713

    DO - 10.1002/cmmi.1713

    M3 - Article

    JO - Contrast Media and Molecular Imaging

    T2 - Contrast Media and Molecular Imaging

    JF - Contrast Media and Molecular Imaging

    SN - 1555-4309

    ER -