Introduction

Research output: Research - peer-reviewEditorial

Abstract

In this special volume on “Chromatin regulation of early embryonic lineage specification,” five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.

LanguageEnglish (US)
Pages1-2
Number of pages2
JournalAdvances in Anatomy Embryology and Cell Biology
Volume229
DOIs
StatePublished - Jan 1 2018

Profile

Chromatin
Mammalian Embryo
Germ Layers
Placentation
Gastrulation
Endoderm
Cell Lineage
Embryonic Development
Embryonic Structures
Gene Expression

ASJC Scopus subject areas

  • Anatomy
  • Embryology
  • Developmental Biology
  • Cell Biology

Cite this

Introduction. / Knott, Jason G.; Latham, Keith E.

In: Advances in Anatomy Embryology and Cell Biology, Vol. 229, 01.01.2018, p. 1-2.

Research output: Research - peer-reviewEditorial

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