Microfabricated high-moment micrometer-sized MRI contrast agents

Gary Zabow, Stephen J. Dodd, Erik Shapiro, John Moreland, Alan P. Koretsky

Research output: Contribution to journalArticle

  • 10 Citations

Abstract

While chemically synthesized superparamagnetic microparticles have enabled much new research based on MRI tracking of magnetically labeled cells, signal-to-noise levels still limit the potential range of applications. Here it is shown how, through top-down microfabrication, contrast agent relaxivity can be increased several-fold, which should extend the sensitivity of such cell-tracking studies. Microfabricated agents can benefit from both higher magnetic moments and higher uniformity than their chemically synthesized counterparts, implying increased label visibility and more quantitative image analyses. To assess the performance of microfabricated micrometer-sized contrast agent particles, analytic models and numerical simulations are developed and tested against new microfabricated agents described in this article, as well as against results of previous imaging studies of traditional chemically synthesized microparticle agents. Experimental data showing signal effects of 500-nm thick, 2-μm diameter, gold-coated iron and gold-coated nickel disks verify the simulations. Additionally, it is suggested that measures of location better than the pixel resolution can be obtained and that these are aided using well-defined contrast agent particles achievable through microfabrication techniques.

Original languageEnglish (US)
Pages (from-to)645-655
Number of pages11
JournalMagnetic Resonance in Medicine
Volume65
Issue number3
DOIs
StatePublished - Mar 2011
Externally publishedYes

Profile

Contrast Media
Microtechnology
Gold
Cell Tracking
Nickel
Noise
Iron

Keywords

  • contrast agent
  • microfabrication
  • microparticle
  • MPIO
  • nanoparticle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Zabow, G., Dodd, S. J., Shapiro, E., Moreland, J., & Koretsky, A. P. (2011). Microfabricated high-moment micrometer-sized MRI contrast agents. Magnetic Resonance in Medicine, 65(3), 645-655. DOI: 10.1002/mrm.22647

Microfabricated high-moment micrometer-sized MRI contrast agents. / Zabow, Gary; Dodd, Stephen J.; Shapiro, Erik; Moreland, John; Koretsky, Alan P.

In: Magnetic Resonance in Medicine, Vol. 65, No. 3, 03.2011, p. 645-655.

Research output: Contribution to journalArticle

Zabow, G, Dodd, SJ, Shapiro, E, Moreland, J & Koretsky, AP 2011, 'Microfabricated high-moment micrometer-sized MRI contrast agents' Magnetic Resonance in Medicine, vol 65, no. 3, pp. 645-655. DOI: 10.1002/mrm.22647
Zabow G, Dodd SJ, Shapiro E, Moreland J, Koretsky AP. Microfabricated high-moment micrometer-sized MRI contrast agents. Magnetic Resonance in Medicine. 2011 Mar;65(3):645-655. Available from, DOI: 10.1002/mrm.22647

Zabow, Gary; Dodd, Stephen J.; Shapiro, Erik; Moreland, John; Koretsky, Alan P. / Microfabricated high-moment micrometer-sized MRI contrast agents.

In: Magnetic Resonance in Medicine, Vol. 65, No. 3, 03.2011, p. 645-655.

Research output: Contribution to journalArticle

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