Modeling the emetic potencies of food-borne trichothecenes by benchmark dose methodology

Denis Male, Wenda Wu, Nicole J. Mitchell, Steven Bursian, James J. Pestka, Felicia Wu

Research output: Contribution to journalArticle

  • 5 Citations

Abstract

Trichothecene mycotoxins commonly co-contaminate cereal products. They cause immunosuppression, anorexia, and emesis in multiple species. Dietary exposure to such toxins often occurs in mixtures. Hence, if it were possible to determine their relative toxicities and assign toxic equivalency factors (TEFs) to each trichothecene, risk management and regulation of these mycotoxins could become more comprehensive and simple. We used a mink emesis model to compare the toxicities of deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, nivalenol, fusarenon-X, HT-2 toxin, and T-2 toxin. These toxins were administered to mink via gavage and intraperitoneal injection. The United States Environmental Protection Agency (EPA) benchmark dose software was used to determine benchmark doses for each trichothecene. The relative potencies of each of these toxins were calculated as the ratios of their benchmark doses to that of DON. Our results showed that mink were more sensitive to orally administered toxins than to toxins administered by IP. T-2 and HT-2 toxins caused the greatest emetic responses, followed by FX, and then by DON, its acetylated derivatives, and NIV. Although these results provide key information on comparative toxicities, there is still a need for more animal based studies focusing on various endpoints and combined effects of trichothecenes before TEFs can be established.

LanguageEnglish (US)
Pages178-185
Number of pages8
JournalFood and Chemical Toxicology
Volume94
DOIs
StatePublished - Aug 1 2016

Profile

Trichothecenes
emetics
Emetics
Benchmarking
trichothecenes
Mink
toxins
mink
Toxicity
Food
Mycotoxins
Poisons
HT-2 toxin
dosage
Vomiting
Cereal products
toxicity
mycotoxins
T-2 Toxin
United States Environmental Protection Agency

Keywords

  • Deoxynivalenol
  • Emesis
  • Mycotoxins
  • Toxic equivalency factor

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Modeling the emetic potencies of food-borne trichothecenes by benchmark dose methodology. / Male, Denis; Wu, Wenda; Mitchell, Nicole J.; Bursian, Steven; Pestka, James J.; Wu, Felicia.

In: Food and Chemical Toxicology, Vol. 94, 01.08.2016, p. 178-185.

Research output: Contribution to journalArticle

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