Modelling the anorectic potencies of food-borne trichothecenes by benchmark dose and incremental area under the curve methodology

D. Male, N. J. Mitchell, W. Wu, S. Bursian, J. Pestka, F. Wu

Research output: Contribution to journalArticle

  • 2 Citations

Abstract

Fusarium spp. fungi produce a spectrum of trichothecene mycotoxins that often simultaneously contaminate cereal grains. These have the potential to contribute jointly to adverse effects such as anorexia and emesis. For the purposes of risk assessment and regulation, it is desirable to assign toxic equivalency factors (TEFs) to each of these trichothecenes, as has been successfully done for anthropogenic toxicants such as polyhalogenated aromatic hydrocarbons. As a first step towards this end, we employed a mouse model to compare the anorectic potencies of deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV), fusarenon-X (FUS-X), T-2 and HT-2 toxin (T-2 and HT-2) following oral exposure by gavage using two approaches. In the first approach, the US Environmental Protection Agency (US EPA) benchmark dose (BMD) method for continuous data was used to calculate the BMD relative to DON 2 h after dosing. The order of potency based on BMD values was: DON(1) ≈ 3-ADON(1) ≈ 15-ADON(1) <NIV(3) <HT-2(5) <FUS-X(9)

LanguageEnglish (US)
Pages279-288
Number of pages10
JournalWorld Mycotoxin Journal
Volume9
Issue number2
DOIs
StatePublished - 2016

Profile

Trichothecenes
Benchmarking
Appetite Depressants
trichothecenes
deoxynivalenol
fusarenon-X
15-acetyldeoxynivalenol
3-acetyldeoxynivalenol
Area Under Curve
nivalenol
Food
dosage
HT-2 toxin
Aromatic Hydrocarbons
United States Environmental Protection Agency
aromatic hydrocarbons
Mycotoxins
Poisons
Environmental Protection Agency
Fusarium

Keywords

  • Anorexia
  • Deoxynivalenol
  • Toxic equivalency factor

ASJC Scopus subject areas

  • Food Science
  • Public Health, Environmental and Occupational Health
  • Toxicology

Cite this

Modelling the anorectic potencies of food-borne trichothecenes by benchmark dose and incremental area under the curve methodology. / Male, D.; Mitchell, N. J.; Wu, W.; Bursian, S.; Pestka, J.; Wu, F.

In: World Mycotoxin Journal, Vol. 9, No. 2, 2016, p. 279-288.

Research output: Contribution to journalArticle

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