Modelling the anorectic potencies of food-borne trichothecenes by benchmark dose and incremental area under the curve methodology

D. Male, N. J. Mitchell, W. Wu, S. Bursian, J. Pestka, F. Wu

    Research output: Contribution to journalArticle

    • 2 Citations

    Abstract

    Fusarium spp. fungi produce a spectrum of trichothecene mycotoxins that often simultaneously contaminate cereal grains. These have the potential to contribute jointly to adverse effects such as anorexia and emesis. For the purposes of risk assessment and regulation, it is desirable to assign toxic equivalency factors (TEFs) to each of these trichothecenes, as has been successfully done for anthropogenic toxicants such as polyhalogenated aromatic hydrocarbons. As a first step towards this end, we employed a mouse model to compare the anorectic potencies of deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV), fusarenon-X (FUS-X), T-2 and HT-2 toxin (T-2 and HT-2) following oral exposure by gavage using two approaches. In the first approach, the US Environmental Protection Agency (US EPA) benchmark dose (BMD) method for continuous data was used to calculate the BMD relative to DON 2 h after dosing. The order of potency based on BMD values was: DON(1) ≈ 3-ADON(1) ≈ 15-ADON(1) <NIV(3) <HT-2(5) <FUS-X(9)

    Original languageEnglish (US)
    Pages (from-to)279-288
    Number of pages10
    JournalWorld Mycotoxin Journal
    Volume9
    Issue number2
    DOIs
    StatePublished - 2016

    Profile

    T-2 Toxin
    Trichothecenes
    Appetite Depressants
    Area Under Curve
    Cereals
    Food
    dosage
    trichothecenes
    deoxynivalenol
    Aromatic Hydrocarbons
    United States Environmental Protection Agency
    Mycotoxins
    Poisons
    Fusarium
    Anorexia
    Vomiting
    Serotonin
    Fungi
    fusarenon-X
    15-acetyldeoxynivalenol

    Keywords

    • Anorexia
    • Deoxynivalenol
    • Toxic equivalency factor

    ASJC Scopus subject areas

    • Food Science
    • Public Health, Environmental and Occupational Health
    • Toxicology

    Cite this

    Modelling the anorectic potencies of food-borne trichothecenes by benchmark dose and incremental area under the curve methodology. / Male, D.; Mitchell, N. J.; Wu, W.; Bursian, S.; Pestka, J.; Wu, F.

    In: World Mycotoxin Journal, Vol. 9, No. 2, 2016, p. 279-288.

    Research output: Contribution to journalArticle

    Male, D.; Mitchell, N. J.; Wu, W.; Bursian, S.; Pestka, J.; Wu, F. / Modelling the anorectic potencies of food-borne trichothecenes by benchmark dose and incremental area under the curve methodology.

    In: World Mycotoxin Journal, Vol. 9, No. 2, 2016, p. 279-288.

    Research output: Contribution to journalArticle

    @article{f07ac98bb58449e2a2a5b866b8d7897c,
    title = "Modelling the anorectic potencies of food-borne trichothecenes by benchmark dose and incremental area under the curve methodology",
    abstract = "Fusarium spp. fungi produce a spectrum of trichothecene mycotoxins that often simultaneously contaminate cereal grains. These have the potential to contribute jointly to adverse effects such as anorexia and emesis. For the purposes of risk assessment and regulation, it is desirable to assign toxic equivalency factors (TEFs) to each of these trichothecenes, as has been successfully done for anthropogenic toxicants such as polyhalogenated aromatic hydrocarbons. As a first step towards this end, we employed a mouse model to compare the anorectic potencies of deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV), fusarenon-X (FUS-X), T-2 and HT-2 toxin (T-2 and HT-2) following oral exposure by gavage using two approaches. In the first approach, the US Environmental Protection Agency (US EPA) benchmark dose (BMD) method for continuous data was used to calculate the BMD relative to DON 2 h after dosing. The order of potency based on BMD values was: DON(1) ≈ 3-ADON(1) ≈ 15-ADON(1) <NIV(3) <HT-2(5) <FUS-X(9)",
    keywords = "Anorexia, Deoxynivalenol, Toxic equivalency factor",
    author = "D. Male and Mitchell, {N. J.} and W. Wu and S. Bursian and J. Pestka and F. Wu",
    year = "2016",
    doi = "10.3920/WMJ2015.1961",
    volume = "9",
    pages = "279--288",
    journal = "World Mycotoxin Journal",
    issn = "1875-0710",
    publisher = "Wageningen Academic Publishers",
    number = "2",

    }

    TY - JOUR

    T1 - Modelling the anorectic potencies of food-borne trichothecenes by benchmark dose and incremental area under the curve methodology

    AU - Male,D.

    AU - Mitchell,N. J.

    AU - Wu,W.

    AU - Bursian,S.

    AU - Pestka,J.

    AU - Wu,F.

    PY - 2016

    Y1 - 2016

    N2 - Fusarium spp. fungi produce a spectrum of trichothecene mycotoxins that often simultaneously contaminate cereal grains. These have the potential to contribute jointly to adverse effects such as anorexia and emesis. For the purposes of risk assessment and regulation, it is desirable to assign toxic equivalency factors (TEFs) to each of these trichothecenes, as has been successfully done for anthropogenic toxicants such as polyhalogenated aromatic hydrocarbons. As a first step towards this end, we employed a mouse model to compare the anorectic potencies of deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV), fusarenon-X (FUS-X), T-2 and HT-2 toxin (T-2 and HT-2) following oral exposure by gavage using two approaches. In the first approach, the US Environmental Protection Agency (US EPA) benchmark dose (BMD) method for continuous data was used to calculate the BMD relative to DON 2 h after dosing. The order of potency based on BMD values was: DON(1) ≈ 3-ADON(1) ≈ 15-ADON(1) <NIV(3) <HT-2(5) <FUS-X(9)

    AB - Fusarium spp. fungi produce a spectrum of trichothecene mycotoxins that often simultaneously contaminate cereal grains. These have the potential to contribute jointly to adverse effects such as anorexia and emesis. For the purposes of risk assessment and regulation, it is desirable to assign toxic equivalency factors (TEFs) to each of these trichothecenes, as has been successfully done for anthropogenic toxicants such as polyhalogenated aromatic hydrocarbons. As a first step towards this end, we employed a mouse model to compare the anorectic potencies of deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV), fusarenon-X (FUS-X), T-2 and HT-2 toxin (T-2 and HT-2) following oral exposure by gavage using two approaches. In the first approach, the US Environmental Protection Agency (US EPA) benchmark dose (BMD) method for continuous data was used to calculate the BMD relative to DON 2 h after dosing. The order of potency based on BMD values was: DON(1) ≈ 3-ADON(1) ≈ 15-ADON(1) <NIV(3) <HT-2(5) <FUS-X(9)

    KW - Anorexia

    KW - Deoxynivalenol

    KW - Toxic equivalency factor

    UR - http://www.scopus.com/inward/record.url?scp=84962154835&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84962154835&partnerID=8YFLogxK

    U2 - 10.3920/WMJ2015.1961

    DO - 10.3920/WMJ2015.1961

    M3 - Article

    VL - 9

    SP - 279

    EP - 288

    JO - World Mycotoxin Journal

    T2 - World Mycotoxin Journal

    JF - World Mycotoxin Journal

    SN - 1875-0710

    IS - 2

    ER -