Monitoring of Antisolvent Addition Crystallization with Raman Spectroscopy

Javier A. Falcon, Kris A. Berglund

Research output: Contribution to journalArticle

  • 11 Citations

Abstract

Fiber optic Raman spectroscopy was used for in situ monitoring of antisolvent addition crystallization of cortisone acetate. Raman spectral features of the solvent, the antisolvent, and the solute were monitored to measure the relative concentration of the components. Different rates of antisolvent addition were monitored and the resulting solid-state form was characterized using Raman spectroscopy and DSC. Raman spectroscopy was used to monitor dehydration during storage of the product crystals. The current study demonstrates the advantages of using Raman spectroscopy to monitor the solution phase during crystallization and simultaneously monitoring the solid-state form.

LanguageEnglish (US)
Pages947-952
Number of pages6
JournalCrystal Growth and Design
Volume3
Issue number6
DOIs
StatePublished - Nov 2003

Profile

Crystallization
Raman spectroscopy
crystallization
Monitoring
cortisone
solid state
Dehydration
dehydration
Fiber optics
acetates
fiber optics
solutes
Crystals
products
crystals

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Monitoring of Antisolvent Addition Crystallization with Raman Spectroscopy. / Falcon, Javier A.; Berglund, Kris A.

In: Crystal Growth and Design, Vol. 3, No. 6, 11.2003, p. 947-952.

Research output: Contribution to journalArticle

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