Monitoring of Antisolvent Addition Crystallization with Raman Spectroscopy

Javier A. Falcon, Kris A. Berglund

    Research output: Contribution to journalArticle

    • 10 Citations

    Abstract

    Fiber optic Raman spectroscopy was used for in situ monitoring of antisolvent addition crystallization of cortisone acetate. Raman spectral features of the solvent, the antisolvent, and the solute were monitored to measure the relative concentration of the components. Different rates of antisolvent addition were monitored and the resulting solid-state form was characterized using Raman spectroscopy and DSC. Raman spectroscopy was used to monitor dehydration during storage of the product crystals. The current study demonstrates the advantages of using Raman spectroscopy to monitor the solution phase during crystallization and simultaneously monitoring the solid-state form.

    Original languageEnglish (US)
    Pages (from-to)947-952
    Number of pages6
    JournalCrystal Growth and Design
    Volume3
    Issue number6
    DOIs
    StatePublished - Nov 2003

    Profile

    Raman spectroscopy
    Experimental Liver Cirrhoses
    crystallization
    Antimony Potassium Tartrate
    Crystallization
    Monitoring
    solid state
    Butylene Glycols
    cortisone
    dehydration
    acetates
    fiber optics
    solutes
    products
    crystals
    Carcinoid Tumor
    Diaphragm
    Dehydration
    Fiber optics
    Crystals

    ASJC Scopus subject areas

    • Chemistry(all)
    • Materials Science(all)
    • Condensed Matter Physics

    Cite this

    Monitoring of Antisolvent Addition Crystallization with Raman Spectroscopy. / Falcon, Javier A.; Berglund, Kris A.

    In: Crystal Growth and Design, Vol. 3, No. 6, 11.2003, p. 947-952.

    Research output: Contribution to journalArticle

    Falcon, Javier A.; Berglund, Kris A. / Monitoring of Antisolvent Addition Crystallization with Raman Spectroscopy.

    In: Crystal Growth and Design, Vol. 3, No. 6, 11.2003, p. 947-952.

    Research output: Contribution to journalArticle

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