Monitoring pH swing crystallization of nicotinic acid by the use of attenuated total reflection Fourier transform infrared spectrometry

Fang Wang, Kris A. Berglund

    Research output: Contribution to journalArticle

    • 30 Citations

    Abstract

    Nicotinic acid is crystallized by adding hydrochloric acid (HCl) to a sodium nicotinate aqueous solution. An attenuated total reflection Fourier transform infrared spectrometer is used to monitor the crystallization process of nicotinic acid. The partial least squares method is employed for IR data analysis. The solubility of nicotinic acid varies with the pH and the concentration of sodium nicotinate. The ability to measure the concentration and solubility of nicotinic acid in situ in aqueous mixtures of nicotinic acid and sodium nicotinate provides the possibility of controlling the degree of supersaturation of the solution and in turn optimizing the crystallization conditions for nicotinic acid.

    Original languageEnglish (US)
    Pages (from-to)2101-2104
    Number of pages4
    JournalIndustrial and Engineering Chemistry Research
    Volume39
    Issue number6
    StatePublished - 2000

    Profile

    Niacin
    Fourier Analysis
    Crystallization
    Spectrum Analysis
    Acids
    acid
    Sodium
    crystallization
    sodium
    Fourier transforms
    Solubility
    Fourier transform
    solubility
    Adnexal Diseases
    Histocompatibility
    Leukopenia
    Infrared spectrometers
    Supersaturation
    Hydrochloric acid
    Spectrometry

    ASJC Scopus subject areas

    • Chemical Engineering (miscellaneous)
    • Environmental Science(all)
    • Polymers and Plastics

    Cite this

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    AU - Berglund,Kris A.

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