Monitoring pH swing crystallization of nicotinic acid by the use of attenuated total reflection Fourier transform infrared spectrometry

Fang Wang, Kris A. Berglund

Research output: Contribution to journalArticle

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Abstract

Nicotinic acid is crystallized by adding hydrochloric acid (HCl) to a sodium nicotinate aqueous solution. An attenuated total reflection Fourier transform infrared spectrometer is used to monitor the crystallization process of nicotinic acid. The partial least squares method is employed for IR data analysis. The solubility of nicotinic acid varies with the pH and the concentration of sodium nicotinate. The ability to measure the concentration and solubility of nicotinic acid in situ in aqueous mixtures of nicotinic acid and sodium nicotinate provides the possibility of controlling the degree of supersaturation of the solution and in turn optimizing the crystallization conditions for nicotinic acid.

LanguageEnglish (US)
Pages2101-2104
Number of pages4
JournalIndustrial and Engineering Chemistry Research
Volume39
Issue number6
StatePublished - 2000

Profile

Niacin
Crystallization
Spectrometry
Fourier transform
spectrometry
Fourier transforms
crystallization
Infrared radiation
Acids
Monitoring
acid
monitoring
Sodium
sodium
solubility
Solubility
Infrared spectrometers
Supersaturation
least squares method
supersaturation

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics

Cite this

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