Nanometal-decorated exfoliated graphite nanoplatelet based glucose biosensors with high sensitivity and fast response

    Research output: Contribution to journalArticle

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    Abstract

    We report the novel fabrication of a highly sensitive, selective, fast responding, and affordable amperometric glucose biosensor using exfoliated graphite nanoplatelets (xGnPs) decorated with Pt and Pd nanoparticles. Nafion was used to solublize metal-decorated graphite nanoplatelets, and a simple cast method with high content organic solvent (85 wt %) was used to prepare the biosensors. The addition of precious metal nanoparticles such as platinum (Pt) and palladium (Pd) to xGnP increased the electroactive area of the electrode and substantially decreased the overpotential in the detection of hydrogen peroxide. The Pt-xGnP glucose biosensor had a sensitivity of 61.5 ± 0.6 μA /(mM · cm2) and gave a linear response up to 20 mM. The response time and detection limit (S/N = 3) were determined to be 2 s and 1 μM, respectively. Therefore, this novel glucose biosensor based on the Pt nanoparticle coated xGnP is among the best reported to date in both sensing performance and production cost. In addition, the effects of metal nanoparticle loading and the particle size on the biosensor performance were systematically investigated.

    Original languageEnglish (US)
    Pages (from-to)1825-1832
    Number of pages8
    JournalACS Nano
    Volume2
    Issue number9
    DOIs
    StatePublished - Sep 2008

    Profile

    bioinstrumentation
    Biosensors
    glucose
    platinum
    nanoparticles
    Glucose
    Platinum
    graphite
    Graphite
    palladium
    sensitivity
    metals
    Metal nanoparticles
    Palladium
    Nanoparticles
    Takayasu Arteritis
    Myosins
    production costs
    noble metals
    hydrogen peroxide

    Keywords

    • Exfoliated graphite nanoplatelets
    • Glucose biosensor
    • Metal nanoparticles
    • Nafion

    ASJC Scopus subject areas

    • Engineering(all)
    • Materials Science(all)
    • Physics and Astronomy(all)

    Cite this

    Nanometal-decorated exfoliated graphite nanoplatelet based glucose biosensors with high sensitivity and fast response. / Lu, Jue; Do, Inhwan; Drzal, Lawrence T.; Worden, Robert M.; Lee, Ilsoon.

    In: ACS Nano, Vol. 2, No. 9, 09.2008, p. 1825-1832.

    Research output: Contribution to journalArticle

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    abstract = "We report the novel fabrication of a highly sensitive, selective, fast responding, and affordable amperometric glucose biosensor using exfoliated graphite nanoplatelets (xGnPs) decorated with Pt and Pd nanoparticles. Nafion was used to solublize metal-decorated graphite nanoplatelets, and a simple cast method with high content organic solvent (85 wt %) was used to prepare the biosensors. The addition of precious metal nanoparticles such as platinum (Pt) and palladium (Pd) to xGnP increased the electroactive area of the electrode and substantially decreased the overpotential in the detection of hydrogen peroxide. The Pt-xGnP glucose biosensor had a sensitivity of 61.5 ± 0.6 μA /(mM · cm2) and gave a linear response up to 20 mM. The response time and detection limit (S/N = 3) were determined to be 2 s and 1 μM, respectively. Therefore, this novel glucose biosensor based on the Pt nanoparticle coated xGnP is among the best reported to date in both sensing performance and production cost. In addition, the effects of metal nanoparticle loading and the particle size on the biosensor performance were systematically investigated.",
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