Novel starch based copolymers (DiHydroxyl Starch) as ocular lubricants: Synthesis and characterizations

Weipeng Liu, Wendy M. Townsend, James Steffe, Ramani Narayan

Research output: Contribution to journalArticle

  • 1 Citations

Abstract

Dry eye syndrome is an ocular tear deficiency disorder that affects millions of people in the United States. It has been recognized as a significant lifestyle issue and is among the most frequently established diagnoses in ophthalmology. Tear substitutes (or artificial tear formulations) are the mainstay of dry eye therapy. While many commercial products are available, their efficacy is limited because of their short retention time in the eye, and/or low patient acceptance. In this study, our objectives were to obtain water soluble products with opened glucose rings along the starch backbone, and tear substitute formulations based on these products with strengthened mucoadhesion, shear thinning behavior, improved tear film stability, and no irritancy to the eye. To this end we have synthesized a series of starch based copolymers, DiHydroxyl Starches (DHS). This modification of starch is not a new science, but the application of these polymers to tear substitutes is novel. These polymers were characterized as ocular lubricants utilizing both in vitro and in vivo testing. Specifically, mucoadhesion and rheological behavior were examined. Their performance as ocular lubricants was evaluated utilizing the tear-film break up times of rabbits before and after application of the copolymers. In addition, the effect of autoclaving and ocular toxicity were tested.

LanguageEnglish (US)
Pages343-351
Number of pages9
JournalJournal of Applied Polymer Science
Volume117
Issue number1
DOIs
StatePublished - Jul 5 2010

Profile

Starch
Lubricants
Copolymers
Polymers
Ophthalmology
Shear thinning
Glucose
Toxicity
Water
Testing

Keywords

  • Biological applications of polymers
  • Biopolymers
  • Dry eye
  • Starch
  • Tear substitute

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Surfaces, Coatings and Films
  • Chemistry(all)

Cite this

Novel starch based copolymers (DiHydroxyl Starch) as ocular lubricants : Synthesis and characterizations. / Liu, Weipeng; Townsend, Wendy M.; Steffe, James; Narayan, Ramani.

In: Journal of Applied Polymer Science, Vol. 117, No. 1, 05.07.2010, p. 343-351.

Research output: Contribution to journalArticle

@article{a19c3d9a1e6d4e55b8fa938e70a357af,
title = "Novel starch based copolymers (DiHydroxyl Starch) as ocular lubricants: Synthesis and characterizations",
abstract = "Dry eye syndrome is an ocular tear deficiency disorder that affects millions of people in the United States. It has been recognized as a significant lifestyle issue and is among the most frequently established diagnoses in ophthalmology. Tear substitutes (or artificial tear formulations) are the mainstay of dry eye therapy. While many commercial products are available, their efficacy is limited because of their short retention time in the eye, and/or low patient acceptance. In this study, our objectives were to obtain water soluble products with opened glucose rings along the starch backbone, and tear substitute formulations based on these products with strengthened mucoadhesion, shear thinning behavior, improved tear film stability, and no irritancy to the eye. To this end we have synthesized a series of starch based copolymers, DiHydroxyl Starches (DHS). This modification of starch is not a new science, but the application of these polymers to tear substitutes is novel. These polymers were characterized as ocular lubricants utilizing both in vitro and in vivo testing. Specifically, mucoadhesion and rheological behavior were examined. Their performance as ocular lubricants was evaluated utilizing the tear-film break up times of rabbits before and after application of the copolymers. In addition, the effect of autoclaving and ocular toxicity were tested.",
keywords = "Biological applications of polymers, Biopolymers, Dry eye, Starch, Tear substitute",
author = "Weipeng Liu and Townsend, {Wendy M.} and James Steffe and Ramani Narayan",
year = "2010",
month = "7",
day = "5",
doi = "10.1002/app.31330",
language = "English (US)",
volume = "117",
pages = "343--351",
journal = "Journal of Applied Polymer Science",
issn = "0021-8995",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Novel starch based copolymers (DiHydroxyl Starch) as ocular lubricants

T2 - Journal of Applied Polymer Science

AU - Liu,Weipeng

AU - Townsend,Wendy M.

AU - Steffe,James

AU - Narayan,Ramani

PY - 2010/7/5

Y1 - 2010/7/5

N2 - Dry eye syndrome is an ocular tear deficiency disorder that affects millions of people in the United States. It has been recognized as a significant lifestyle issue and is among the most frequently established diagnoses in ophthalmology. Tear substitutes (or artificial tear formulations) are the mainstay of dry eye therapy. While many commercial products are available, their efficacy is limited because of their short retention time in the eye, and/or low patient acceptance. In this study, our objectives were to obtain water soluble products with opened glucose rings along the starch backbone, and tear substitute formulations based on these products with strengthened mucoadhesion, shear thinning behavior, improved tear film stability, and no irritancy to the eye. To this end we have synthesized a series of starch based copolymers, DiHydroxyl Starches (DHS). This modification of starch is not a new science, but the application of these polymers to tear substitutes is novel. These polymers were characterized as ocular lubricants utilizing both in vitro and in vivo testing. Specifically, mucoadhesion and rheological behavior were examined. Their performance as ocular lubricants was evaluated utilizing the tear-film break up times of rabbits before and after application of the copolymers. In addition, the effect of autoclaving and ocular toxicity were tested.

AB - Dry eye syndrome is an ocular tear deficiency disorder that affects millions of people in the United States. It has been recognized as a significant lifestyle issue and is among the most frequently established diagnoses in ophthalmology. Tear substitutes (or artificial tear formulations) are the mainstay of dry eye therapy. While many commercial products are available, their efficacy is limited because of their short retention time in the eye, and/or low patient acceptance. In this study, our objectives were to obtain water soluble products with opened glucose rings along the starch backbone, and tear substitute formulations based on these products with strengthened mucoadhesion, shear thinning behavior, improved tear film stability, and no irritancy to the eye. To this end we have synthesized a series of starch based copolymers, DiHydroxyl Starches (DHS). This modification of starch is not a new science, but the application of these polymers to tear substitutes is novel. These polymers were characterized as ocular lubricants utilizing both in vitro and in vivo testing. Specifically, mucoadhesion and rheological behavior were examined. Their performance as ocular lubricants was evaluated utilizing the tear-film break up times of rabbits before and after application of the copolymers. In addition, the effect of autoclaving and ocular toxicity were tested.

KW - Biological applications of polymers

KW - Biopolymers

KW - Dry eye

KW - Starch

KW - Tear substitute

UR - http://www.scopus.com/inward/record.url?scp=77950930531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950930531&partnerID=8YFLogxK

U2 - 10.1002/app.31330

DO - 10.1002/app.31330

M3 - Article

VL - 117

SP - 343

EP - 351

JO - Journal of Applied Polymer Science

JF - Journal of Applied Polymer Science

SN - 0021-8995

IS - 1

ER -