Prediction of therapeutic microRNA based on the human metabolic network

    Research output: Research - peer-reviewArticle

    • 6 Citations

    Abstract

    Motivation: MicroRNA (miRNA) expression has been found to be deregulated in human cancer, contributing, in part, to the interest of the research community in using miRNAs as alternative therapeutic targets. Although miRNAs could be potential targets, identifying which miRNAs to target for a particular type of cancer has been difficult due to the limited knowledge on their regulatory roles in cancer. We address this challenge by integrating miRNA-target prediction, metabolic modeling and context-specific gene expression data to predict therapeutic miRNAs that could reduce the growth of cancer.Results: We developed a novel approach to simulate a condition-specific metabolic system for human hepatocellular carcinoma (HCC) wherein overexpression of each miRNA was simulated to predict their ability to reduce cancer cell growth. Our approach achieved >80% accuracy in predicting the miRNAs that could suppress metastasis and progression of liver cancer based on various experimental evidences in the literature. This condition-specific metabolic system provides a framework to explore the mechanisms by which miRNAs modulate metabolic functions to affect cancer growth. To the best of our knowledge, this is the first computational approach implemented to predict therapeutic miRNAs for human cancer based on their functional role in cancer metabolism. Analyzing the metabolic functions altered by the miRNA-identified metabolic genes essential for cell growth and proliferation that are targeted by the miRNAs.

    LanguageEnglish (US)
    Pages1163-1171
    Number of pages9
    JournalBioinformatics
    Volume30
    Issue number8
    DOIs
    StatePublished - 2014

    Profile

    MicroRNA
    Metabolic Network
    Prediction
    Human
    Metabolic Networks and Pathways
    MicroRNAs
    Therapeutics
    Cell growth
    Cancer
    Neoplasms
    Cell proliferation
    Metabolism
    Gene expression
    Liver
    Genes
    Target
    Growth
    Predict
    Cell
    Knowledge

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Computational Theory and Mathematics
    • Computer Science Applications
    • Computational Mathematics
    • Statistics and Probability

    Cite this

    Prediction of therapeutic microRNA based on the human metabolic network. / Wu, Ming; Chan, Christina.

    In: Bioinformatics, Vol. 30, No. 8, 2014, p. 1163-1171.

    Research output: Research - peer-reviewArticle

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    abstract = "Motivation: MicroRNA (miRNA) expression has been found to be deregulated in human cancer, contributing, in part, to the interest of the research community in using miRNAs as alternative therapeutic targets. Although miRNAs could be potential targets, identifying which miRNAs to target for a particular type of cancer has been difficult due to the limited knowledge on their regulatory roles in cancer. We address this challenge by integrating miRNA-target prediction, metabolic modeling and context-specific gene expression data to predict therapeutic miRNAs that could reduce the growth of cancer.Results: We developed a novel approach to simulate a condition-specific metabolic system for human hepatocellular carcinoma (HCC) wherein overexpression of each miRNA was simulated to predict their ability to reduce cancer cell growth. Our approach achieved >80% accuracy in predicting the miRNAs that could suppress metastasis and progression of liver cancer based on various experimental evidences in the literature. This condition-specific metabolic system provides a framework to explore the mechanisms by which miRNAs modulate metabolic functions to affect cancer growth. To the best of our knowledge, this is the first computational approach implemented to predict therapeutic miRNAs for human cancer based on their functional role in cancer metabolism. Analyzing the metabolic functions altered by the miRNA-identified metabolic genes essential for cell growth and proliferation that are targeted by the miRNAs.",
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