Proteoglycan loss in human knee cartilage: Quantitation with sodium MR imaging - Feasibility study

Andrew J. Wheaton, Arijitt Borthakur, Erik M. Shapiro, Ravinder R. Regatte, Sarma V S Akella, J. Bruce Kneeland, Ravinder Reddy

Research output: Contribution to journalArticle

  • 108 Citations

Abstract

The feasibility of using sodium magnetic resonance (MR) imaging to detect proteoglycan loss in early-stage osteoarthritis is evaluated. Fixed charge density (FCD) maps were calculated from sodium MR imaging data collected in nine healthy volunteers and three individuals with symptoms of early-stage osteoarthritis by using a 4.0-T clinical MR imaging unit. Data from the healthy individuals revealed a mean FCD of -182 mmol/L ± 9. Data from the symptomatic subjects revealed focal regions of decreased FCD, with mean values ranging from -108 to -144 mmol/L, indicating proteoglycan loss from the cartilage matrix. The data suggest that sodium MR imaging has potential for use as a quantitative diagnostic tool to measure changes in proteoglycan content in early-stage osteoarthritis.

Original languageEnglish (US)
Pages (from-to)900-905
Number of pages6
JournalRadiology
Volume231
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

Profile

Feasibility Studies
Proteoglycans
Cartilage
Knee
Sodium
Magnetic Resonance Imaging
Osteoarthritis
Healthy Volunteers

Keywords

  • Arthritis, degenerative
  • Cartilage, MR
  • Knee, MR
  • Magnetic resonance (MR), sodium studies
  • Patella
  • Test objects

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Wheaton, A. J., Borthakur, A., Shapiro, E. M., Regatte, R. R., Akella, S. V. S., Kneeland, J. B., & Reddy, R. (2004). Proteoglycan loss in human knee cartilage: Quantitation with sodium MR imaging - Feasibility study. Radiology, 231(3), 900-905. DOI: 10.1148/radiol.2313030521

Proteoglycan loss in human knee cartilage : Quantitation with sodium MR imaging - Feasibility study. / Wheaton, Andrew J.; Borthakur, Arijitt; Shapiro, Erik M.; Regatte, Ravinder R.; Akella, Sarma V S; Kneeland, J. Bruce; Reddy, Ravinder.

In: Radiology, Vol. 231, No. 3, 06.2004, p. 900-905.

Research output: Contribution to journalArticle

Wheaton, AJ, Borthakur, A, Shapiro, EM, Regatte, RR, Akella, SVS, Kneeland, JB & Reddy, R 2004, 'Proteoglycan loss in human knee cartilage: Quantitation with sodium MR imaging - Feasibility study' Radiology, vol 231, no. 3, pp. 900-905. DOI: 10.1148/radiol.2313030521
Wheaton AJ, Borthakur A, Shapiro EM, Regatte RR, Akella SVS, Kneeland JB et al. Proteoglycan loss in human knee cartilage: Quantitation with sodium MR imaging - Feasibility study. Radiology. 2004 Jun;231(3):900-905. Available from, DOI: 10.1148/radiol.2313030521

Wheaton, Andrew J.; Borthakur, Arijitt; Shapiro, Erik M.; Regatte, Ravinder R.; Akella, Sarma V S; Kneeland, J. Bruce; Reddy, Ravinder / Proteoglycan loss in human knee cartilage : Quantitation with sodium MR imaging - Feasibility study.

In: Radiology, Vol. 231, No. 3, 06.2004, p. 900-905.

Research output: Contribution to journalArticle

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