Spectroscopic monitoring of environmentally benign anti-solvent crystallization

M. Uusi-Penttilä, K. A. Berglund

Research output: Contribution to journalArticle

  • 11 Citations

Abstract

There are very few studies dealing with the fundamentals of anti-solvent crystallization, even though this crystallization method is widely used in the pharmaceutical industry. Anti-solvent crystallization is accomplished by adding a miscible anti-solvent into a mixture of solute and solvent, effectively reducing the solubility of the solute in the solvent, and thus, causing the crystallization of the solute. Unfortunately, many of the anti-solvents used today are chlorinated hydrocarbons suspected of environmental damage. The current research demonstrates the use of environmentally benign solvents for anti-solvent crystallization and new approaches for monitoring of the solvent behavior during an anti-solvent crystallization. Results are presented confirming the efficacy of various water and ester systems for anti-solvent crystallization. Furthermore, the application of fluorescence spectroscopy for monitoring these crystallizations is demonstrated.

LanguageEnglish (US)
Pages967-970
Number of pages4
JournalJournal of Crystal Growth
Volume166
Issue number1-4
StatePublished - Sep 1996

Profile

Crystallization
crystallization
Monitoring
solutes
Chlorinated Hydrocarbons
Fluorescence spectroscopy
Drug products
esters
Esters
solubility
Solubility
hydrocarbons
industries
damage
fluorescence
Water

ASJC Scopus subject areas

  • Condensed Matter Physics

Cite this

Spectroscopic monitoring of environmentally benign anti-solvent crystallization. / Uusi-Penttilä, M.; Berglund, K. A.

In: Journal of Crystal Growth, Vol. 166, No. 1-4, 09.1996, p. 967-970.

Research output: Contribution to journalArticle

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