Spectroscopic monitoring of environmentally benign anti-solvent crystallization

M. Uusi-Penttilä, K. A. Berglund

    Research output: Research - peer-reviewArticle

    • 10 Citations

    Abstract

    There are very few studies dealing with the fundamentals of anti-solvent crystallization, even though this crystallization method is widely used in the pharmaceutical industry. Anti-solvent crystallization is accomplished by adding a miscible anti-solvent into a mixture of solute and solvent, effectively reducing the solubility of the solute in the solvent, and thus, causing the crystallization of the solute. Unfortunately, many of the anti-solvents used today are chlorinated hydrocarbons suspected of environmental damage. The current research demonstrates the use of environmentally benign solvents for anti-solvent crystallization and new approaches for monitoring of the solvent behavior during an anti-solvent crystallization. Results are presented confirming the efficacy of various water and ester systems for anti-solvent crystallization. Furthermore, the application of fluorescence spectroscopy for monitoring these crystallizations is demonstrated.

    LanguageEnglish (US)
    Pages967-970
    Number of pages4
    JournalJournal of Crystal Growth
    Volume166
    Issue number1-4
    StatePublished - Sep 1996

    Profile

    Crystallization
    Monitoring
    crystallization
    solutes
    Chlorinated Hydrocarbons
    Fluorescence spectroscopy
    Esters
    Solubility
    Water
    Pharmaceutical Preparations
    Industry
    Drug products
    esters
    solubility
    hydrocarbons
    industries
    damage
    fluorescence
    water
    spectroscopy

    ASJC Scopus subject areas

    • Condensed Matter Physics

    Cite this

    Spectroscopic monitoring of environmentally benign anti-solvent crystallization. / Uusi-Penttilä, M.; Berglund, K. A.

    In: Journal of Crystal Growth, Vol. 166, No. 1-4, 09.1996, p. 967-970.

    Research output: Research - peer-reviewArticle

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