Substrate channelling as an approach to cascade reactions

Ian Wheeldon, Shelley D. Minteer, Scott Banta, Scott Calabrese Barton, Plamen Atanassov, Matthew Sigman

Research output: Contribution to journalArticle

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Abstract

Millions of years of evolution have produced biological systems capable of efficient one-pot multi-step catalysis. The underlying mechanisms that facilitate these reaction processes are increasingly providing inspiration in synthetic chemistry. Substrate channelling, where intermediates between enzymatic steps are not in equilibrium with the bulk solution, enables increased efficiencies and yields in reaction and diffusion processes. Here, we review different mechanisms of substrate channelling found in nature and provide an overview of the analytical methods used to quantify these effects. The incorporation of substrate channelling into synthetic cascades is a rapidly developing concept, and recent examples of the fabrication of cascades with controlled diffusion and flux of intermediates are presented.

LanguageEnglish (US)
Pages299-309
Number of pages11
JournalNature Chemistry
Volume8
Issue number4
DOIs
StatePublished - Mar 22 2016

Profile

Substrates
Biological systems
Catalysis
Fluxes
Fabrication

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Wheeldon, I., Minteer, S. D., Banta, S., Barton, S. C., Atanassov, P., & Sigman, M. (2016). Substrate channelling as an approach to cascade reactions. Nature Chemistry, 8(4), 299-309. DOI: 10.1038/nchem.2459

Substrate channelling as an approach to cascade reactions. / Wheeldon, Ian; Minteer, Shelley D.; Banta, Scott; Barton, Scott Calabrese; Atanassov, Plamen; Sigman, Matthew.

In: Nature Chemistry, Vol. 8, No. 4, 22.03.2016, p. 299-309.

Research output: Contribution to journalArticle

Wheeldon, I, Minteer, SD, Banta, S, Barton, SC, Atanassov, P & Sigman, M 2016, 'Substrate channelling as an approach to cascade reactions' Nature Chemistry, vol. 8, no. 4, pp. 299-309. DOI: 10.1038/nchem.2459
Wheeldon I, Minteer SD, Banta S, Barton SC, Atanassov P, Sigman M. Substrate channelling as an approach to cascade reactions. Nature Chemistry. 2016 Mar 22;8(4):299-309. Available from, DOI: 10.1038/nchem.2459
Wheeldon, Ian ; Minteer, Shelley D. ; Banta, Scott ; Barton, Scott Calabrese ; Atanassov, Plamen ; Sigman, Matthew. / Substrate channelling as an approach to cascade reactions. In: Nature Chemistry. 2016 ; Vol. 8, No. 4. pp. 299-309
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