Substrate channelling as an approach to cascade reactions

Ian Wheeldon, Shelley D. Minteer, Scott Banta, Scott Calabrese Barton, Plamen Atanassov, Matthew Sigman

    Research output: Research - peer-reviewArticle

    • 58 Citations

    Abstract

    Millions of years of evolution have produced biological systems capable of efficient one-pot multi-step catalysis. The underlying mechanisms that facilitate these reaction processes are increasingly providing inspiration in synthetic chemistry. Substrate channelling, where intermediates between enzymatic steps are not in equilibrium with the bulk solution, enables increased efficiencies and yields in reaction and diffusion processes. Here, we review different mechanisms of substrate channelling found in nature and provide an overview of the analytical methods used to quantify these effects. The incorporation of substrate channelling into synthetic cascades is a rapidly developing concept, and recent examples of the fabrication of cascades with controlled diffusion and flux of intermediates are presented.

    LanguageEnglish (US)
    Pages299-309
    Number of pages11
    JournalNature Chemistry
    Volume8
    Issue number4
    DOIs
    StatePublished - Mar 22 2016

    Profile

    Substrates
    Biological systems
    Catalysis
    Fluxes
    Fabrication

    ASJC Scopus subject areas

    • Chemistry(all)
    • Chemical Engineering(all)

    Cite this

    Wheeldon, I., Minteer, S. D., Banta, S., Barton, S. C., Atanassov, P., & Sigman, M. (2016). Substrate channelling as an approach to cascade reactions. Nature Chemistry, 8(4), 299-309. DOI: 10.1038/nchem.2459

    Substrate channelling as an approach to cascade reactions. / Wheeldon, Ian; Minteer, Shelley D.; Banta, Scott; Barton, Scott Calabrese; Atanassov, Plamen; Sigman, Matthew.

    In: Nature Chemistry, Vol. 8, No. 4, 22.03.2016, p. 299-309.

    Research output: Research - peer-reviewArticle

    Wheeldon, I, Minteer, SD, Banta, S, Barton, SC, Atanassov, P & Sigman, M 2016, 'Substrate channelling as an approach to cascade reactions' Nature Chemistry, vol 8, no. 4, pp. 299-309. DOI: 10.1038/nchem.2459
    Wheeldon I, Minteer SD, Banta S, Barton SC, Atanassov P, Sigman M. Substrate channelling as an approach to cascade reactions. Nature Chemistry. 2016 Mar 22;8(4):299-309. Available from, DOI: 10.1038/nchem.2459
    Wheeldon, Ian ; Minteer, Shelley D. ; Banta, Scott ; Barton, Scott Calabrese ; Atanassov, Plamen ; Sigman, Matthew. / Substrate channelling as an approach to cascade reactions. In: Nature Chemistry. 2016 ; Vol. 8, No. 4. pp. 299-309
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