Surface engineering of bismuth nanocrystals to counter dissolution

Shatadru Chakravarty, Jason Unold, Dorela D. Shuboni-Mulligan, Barbara Blanco-Fernandez, Erik M. Shapiro

    Research output: Research - peer-reviewArticle

    • 3 Citations

    Abstract

    Rapid dissolution of Bi Nanocrystals (NCs) in lysosomal conditions results in poor biocompatibility. We report that an in situ surface coating of Bi nanocrystals with Ganex® V216, a cosmetic dispersant, limits its dissolution under physiological conditions. These Bi Ganex (BiG) NCs are readily encapsulated in FDA approved polymer poly(dl-lactic-co-glycolic acid) (PLGA) by an oil-in-water emulsion technique and also undergo facile SiO2 coating. BiG NCs in BiG@PLGA and BiG@SiO2 nanoparticles dissolve slowly under physiological conditions and exhibit excellent biocompatibility, as opposed to uncoated Bi NCs. Finally, these Bi nanoconstructs are shown to be strong CT CAs, even at relatively low Bi concentrations.

    LanguageEnglish (US)
    Pages13217-13222
    Number of pages6
    JournalNanoscale
    Volume8
    Issue number27
    DOIs
    StatePublished - Jul 21 2016

    Profile

    Crystal counters
    Bismuth
    Nanocrystals
    Dissolution
    glycolic acid
    Biocompatibility
    Coatings
    Milk
    Acids
    Cosmetics
    Emulsions
    Polymers
    Oils
    Nanoparticles
    Water

    ASJC Scopus subject areas

    • Materials Science(all)

    Cite this

    Chakravarty, S., Unold, J., Shuboni-Mulligan, D. D., Blanco-Fernandez, B., & Shapiro, E. M. (2016). Surface engineering of bismuth nanocrystals to counter dissolution. Nanoscale, 8(27), 13217-13222. DOI: 10.1039/c6nr02171a

    Surface engineering of bismuth nanocrystals to counter dissolution. / Chakravarty, Shatadru; Unold, Jason; Shuboni-Mulligan, Dorela D.; Blanco-Fernandez, Barbara; Shapiro, Erik M.

    In: Nanoscale, Vol. 8, No. 27, 21.07.2016, p. 13217-13222.

    Research output: Research - peer-reviewArticle

    Chakravarty, S, Unold, J, Shuboni-Mulligan, DD, Blanco-Fernandez, B & Shapiro, EM 2016, 'Surface engineering of bismuth nanocrystals to counter dissolution' Nanoscale, vol 8, no. 27, pp. 13217-13222. DOI: 10.1039/c6nr02171a
    Chakravarty S, Unold J, Shuboni-Mulligan DD, Blanco-Fernandez B, Shapiro EM. Surface engineering of bismuth nanocrystals to counter dissolution. Nanoscale. 2016 Jul 21;8(27):13217-13222. Available from, DOI: 10.1039/c6nr02171a
    Chakravarty, Shatadru ; Unold, Jason ; Shuboni-Mulligan, Dorela D. ; Blanco-Fernandez, Barbara ; Shapiro, Erik M./ Surface engineering of bismuth nanocrystals to counter dissolution. In: Nanoscale. 2016 ; Vol. 8, No. 27. pp. 13217-13222
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