Surface engineering of bismuth nanocrystals to counter dissolution

Shatadru Chakravarty, Jason Unold, Dorela D. Shuboni-Mulligan, Barbara Blanco-Fernandez, Erik M. Shapiro

Research output: Contribution to journalArticle

  • 4 Citations

Abstract

Rapid dissolution of Bi Nanocrystals (NCs) in lysosomal conditions results in poor biocompatibility. We report that an in situ surface coating of Bi nanocrystals with Ganex® V216, a cosmetic dispersant, limits its dissolution under physiological conditions. These Bi Ganex (BiG) NCs are readily encapsulated in FDA approved polymer poly(dl-lactic-co-glycolic acid) (PLGA) by an oil-in-water emulsion technique and also undergo facile SiO2 coating. BiG NCs in BiG@PLGA and BiG@SiO2 nanoparticles dissolve slowly under physiological conditions and exhibit excellent biocompatibility, as opposed to uncoated Bi NCs. Finally, these Bi nanoconstructs are shown to be strong CT CAs, even at relatively low Bi concentrations.

LanguageEnglish (US)
Pages13217-13222
Number of pages6
JournalNanoscale
Volume8
Issue number27
DOIs
StatePublished - Jul 21 2016

Profile

Crystal counters
Bismuth
glycolic acid
Nanocrystals
Dissolution
Biocompatibility
Coatings
Acids
Cosmetics
Emulsions
Polymers
Oils
Nanoparticles
Water

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Chakravarty, S., Unold, J., Shuboni-Mulligan, D. D., Blanco-Fernandez, B., & Shapiro, E. M. (2016). Surface engineering of bismuth nanocrystals to counter dissolution. Nanoscale, 8(27), 13217-13222. DOI: 10.1039/c6nr02171a

Surface engineering of bismuth nanocrystals to counter dissolution. / Chakravarty, Shatadru; Unold, Jason; Shuboni-Mulligan, Dorela D.; Blanco-Fernandez, Barbara; Shapiro, Erik M.

In: Nanoscale, Vol. 8, No. 27, 21.07.2016, p. 13217-13222.

Research output: Contribution to journalArticle

Chakravarty, S, Unold, J, Shuboni-Mulligan, DD, Blanco-Fernandez, B & Shapiro, EM 2016, 'Surface engineering of bismuth nanocrystals to counter dissolution' Nanoscale, vol 8, no. 27, pp. 13217-13222. DOI: 10.1039/c6nr02171a
Chakravarty S, Unold J, Shuboni-Mulligan DD, Blanco-Fernandez B, Shapiro EM. Surface engineering of bismuth nanocrystals to counter dissolution. Nanoscale. 2016 Jul 21;8(27):13217-13222. Available from, DOI: 10.1039/c6nr02171a
Chakravarty, Shatadru ; Unold, Jason ; Shuboni-Mulligan, Dorela D. ; Blanco-Fernandez, Barbara ; Shapiro, Erik M./ Surface engineering of bismuth nanocrystals to counter dissolution. In: Nanoscale. 2016 ; Vol. 8, No. 27. pp. 13217-13222
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