The role of inflammasome in Alzheimer's disease

    Research output: Research - peer-reviewArticle

    • 66 Citations

    Abstract

    Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. Inflammation in the central nervous system (CNS) is characterized by the activation of glial cells and release of proinflammatory cytokines and chemokines. Accumulating evidence demonstrates that inflammasomes, which cleave precursors of interleukin-1β (IL-1β) and IL-18 to generate their active forms, play an important role in the inflammatory response in the CNS and in AD pathogenesis. Therefore, modulating inflammasome complex assembly and activation could be a potential strategy for suppressing inflammation in the CNS. This review aims to provide insight into the role of inflammasomes in the CNS, with respect to the pathogenesis of AD, and may provide possible clues for devising novel therapeutic strategies.

    LanguageEnglish (US)
    Pages6-15
    Number of pages10
    JournalAgeing Research Reviews
    Volume15
    Issue number1
    DOIs
    StatePublished - 2014

    Profile

    Inflammasomes
    Alzheimer Disease
    Central Nervous System
    Neurology
    Inflammation
    Chemical activation
    Interleukin-18
    Memory Disorders
    Interleukin-1beta
    Chemokines
    Neuroglia
    Neurodegenerative Diseases
    Dementia
    Cytokines
    Therapeutics
    Cognitive Dysfunction
    Neurodegenerative diseases
    Data storage equipment

    Keywords

    • Alzheimer's disease
    • Astrocytes
    • Inflammasome
    • Inflammation
    • Interleukins
    • Micrioglia

    ASJC Scopus subject areas

    • Aging
    • Biochemistry
    • Biotechnology
    • Molecular Biology
    • Neurology
    • Medicine(all)

    Cite this

    The role of inflammasome in Alzheimer's disease. / Liu, Li; Chan, Christina.

    In: Ageing Research Reviews, Vol. 15, No. 1, 2014, p. 6-15.

    Research output: Research - peer-reviewArticle

    @article{c7d261a86fe34802a7015bbb906ddfc2,
    title = "The role of inflammasome in Alzheimer's disease",
    abstract = "Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. Inflammation in the central nervous system (CNS) is characterized by the activation of glial cells and release of proinflammatory cytokines and chemokines. Accumulating evidence demonstrates that inflammasomes, which cleave precursors of interleukin-1β (IL-1β) and IL-18 to generate their active forms, play an important role in the inflammatory response in the CNS and in AD pathogenesis. Therefore, modulating inflammasome complex assembly and activation could be a potential strategy for suppressing inflammation in the CNS. This review aims to provide insight into the role of inflammasomes in the CNS, with respect to the pathogenesis of AD, and may provide possible clues for devising novel therapeutic strategies.",
    keywords = "Alzheimer's disease, Astrocytes, Inflammasome, Inflammation, Interleukins, Micrioglia",
    author = "Li Liu and Christina Chan",
    year = "2014",
    doi = "10.1016/j.arr.2013.12.007",
    volume = "15",
    pages = "6--15",
    journal = "Ageing Research Reviews",
    issn = "1568-1637",
    publisher = "Elsevier Ireland Ltd",
    number = "1",

    }

    TY - JOUR

    T1 - The role of inflammasome in Alzheimer's disease

    AU - Liu,Li

    AU - Chan,Christina

    PY - 2014

    Y1 - 2014

    N2 - Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. Inflammation in the central nervous system (CNS) is characterized by the activation of glial cells and release of proinflammatory cytokines and chemokines. Accumulating evidence demonstrates that inflammasomes, which cleave precursors of interleukin-1β (IL-1β) and IL-18 to generate their active forms, play an important role in the inflammatory response in the CNS and in AD pathogenesis. Therefore, modulating inflammasome complex assembly and activation could be a potential strategy for suppressing inflammation in the CNS. This review aims to provide insight into the role of inflammasomes in the CNS, with respect to the pathogenesis of AD, and may provide possible clues for devising novel therapeutic strategies.

    AB - Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. Inflammation in the central nervous system (CNS) is characterized by the activation of glial cells and release of proinflammatory cytokines and chemokines. Accumulating evidence demonstrates that inflammasomes, which cleave precursors of interleukin-1β (IL-1β) and IL-18 to generate their active forms, play an important role in the inflammatory response in the CNS and in AD pathogenesis. Therefore, modulating inflammasome complex assembly and activation could be a potential strategy for suppressing inflammation in the CNS. This review aims to provide insight into the role of inflammasomes in the CNS, with respect to the pathogenesis of AD, and may provide possible clues for devising novel therapeutic strategies.

    KW - Alzheimer's disease

    KW - Astrocytes

    KW - Inflammasome

    KW - Inflammation

    KW - Interleukins

    KW - Micrioglia

    UR - http://www.scopus.com/inward/record.url?scp=84896324370&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84896324370&partnerID=8YFLogxK

    U2 - 10.1016/j.arr.2013.12.007

    DO - 10.1016/j.arr.2013.12.007

    M3 - Article

    VL - 15

    SP - 6

    EP - 15

    JO - Ageing Research Reviews

    T2 - Ageing Research Reviews

    JF - Ageing Research Reviews

    SN - 1568-1637

    IS - 1

    ER -