The role of inflammasome in Alzheimer's disease

Research output: Contribution to journalArticle

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Abstract

Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. Inflammation in the central nervous system (CNS) is characterized by the activation of glial cells and release of proinflammatory cytokines and chemokines. Accumulating evidence demonstrates that inflammasomes, which cleave precursors of interleukin-1β (IL-1β) and IL-18 to generate their active forms, play an important role in the inflammatory response in the CNS and in AD pathogenesis. Therefore, modulating inflammasome complex assembly and activation could be a potential strategy for suppressing inflammation in the CNS. This review aims to provide insight into the role of inflammasomes in the CNS, with respect to the pathogenesis of AD, and may provide possible clues for devising novel therapeutic strategies.

LanguageEnglish (US)
Pages6-15
Number of pages10
JournalAgeing Research Reviews
Volume15
Issue number1
DOIs
StatePublished - 2014

Profile

Inflammasomes
Neurology
Alzheimer Disease
Central Nervous System
Inflammation
Chemical activation
Neurodegenerative diseases
Interleukin-18
Memory Disorders
Interleukin-1beta
Chemokines
Neuroglia
Neurodegenerative Diseases
Dementia
Cytokines
Data storage equipment

Keywords

  • Alzheimer's disease
  • Astrocytes
  • Inflammasome
  • Inflammation
  • Interleukins
  • Micrioglia

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology
  • Medicine(all)

Cite this

The role of inflammasome in Alzheimer's disease. / Liu, Li; Chan, Christina.

In: Ageing Research Reviews, Vol. 15, No. 1, 2014, p. 6-15.

Research output: Contribution to journalArticle

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