Transitional behavior of polymeric hollow microsphere formation in turbulent shear flow by emulsion diffusion method

Shaowen Ji, Devesh Srivastava, Nathan J. Parker, Ilsoon Lee

    Research output: Contribution to journalArticle

    • 12 Citations

    Abstract

    Polymeric hollow microspheres have attracted growing attention because of their unique properties and extensive applications. We report a facile emulsion diffusion process to fabricate polylactic acid (PLA) hollow microspheres driven by viscous turbulent fluid flow. The process involves the emulsification of PLA-ethyl acetate solution in the water-glycerol medium under high viscous turbulent shear flow where emulsion droplets coalesce into multiple emulsions, and the solidification of PLA by the diffusion of ethyl acetate. The addition of glycerol changed the viscosity of the continuous aqueous phase, resulting in the transition of fluid flow from inertial turbulent to viscous turbulent dominant regime and thus PLA particle size and shape from solid nanospheres to hollow microspheres. The emulsification temperature also needs to exceed the glass transition temperature of PLA to form hollow microstructure. This method allows the easy control of PLA particle shape and size for different applications.

    Original languageEnglish (US)
    Pages (from-to)205-212
    Number of pages8
    JournalPolymer
    Volume53
    Issue number1
    DOIs
    StatePublished - Jan 5 2012

    Profile

    Acids
    Microspheres
    Emulsions
    Feline Sarcoma Viruses
    Emulsification
    Shear flow
    Glycerol
    Flow of fluids
    Adie Syndrome
    Fallopian Tubes
    Nanospheres
    Solidification
    Particle size
    Viscosity
    Microstructure
    Water
    Temperature
    Acetanilides
    Dental Staff
    Fingersucking

    Keywords

    • Emulsion diffusion
    • Hollow microspheres
    • Turbulent eddies

    ASJC Scopus subject areas

    • Organic Chemistry
    • Polymers and Plastics

    Cite this

    Transitional behavior of polymeric hollow microsphere formation in turbulent shear flow by emulsion diffusion method. / Ji, Shaowen; Srivastava, Devesh; Parker, Nathan J.; Lee, Ilsoon.

    In: Polymer, Vol. 53, No. 1, 05.01.2012, p. 205-212.

    Research output: Contribution to journalArticle

    Ji, Shaowen; Srivastava, Devesh; Parker, Nathan J.; Lee, Ilsoon / Transitional behavior of polymeric hollow microsphere formation in turbulent shear flow by emulsion diffusion method.

    In: Polymer, Vol. 53, No. 1, 05.01.2012, p. 205-212.

    Research output: Contribution to journalArticle

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    abstract = "Polymeric hollow microspheres have attracted growing attention because of their unique properties and extensive applications. We report a facile emulsion diffusion process to fabricate polylactic acid (PLA) hollow microspheres driven by viscous turbulent fluid flow. The process involves the emulsification of PLA-ethyl acetate solution in the water-glycerol medium under high viscous turbulent shear flow where emulsion droplets coalesce into multiple emulsions, and the solidification of PLA by the diffusion of ethyl acetate. The addition of glycerol changed the viscosity of the continuous aqueous phase, resulting in the transition of fluid flow from inertial turbulent to viscous turbulent dominant regime and thus PLA particle size and shape from solid nanospheres to hollow microspheres. The emulsification temperature also needs to exceed the glass transition temperature of PLA to form hollow microstructure. This method allows the easy control of PLA particle shape and size for different applications.",
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