Ultrasensitive Response Motifs in Biochemical Networks

Qiang Zhang, Sudin Bhattacharya, Courtney G. Woods, Melvin E. Andersen

Research output: Chapter in Book/Report/Conference proceedingChapter

  • 2 Citations
Original languageEnglish (US)
Title of host publicationQuantitative Modeling in Toxicology
PublisherJohn Wiley and Sons
Pages199-217
Number of pages19
ISBN (Print)9780470998090
DOIs
StatePublished - Mar 30 2010
Externally publishedYes

Keywords

  • Combination of motifs - six ultrasensitive motifs, in signal transduction and gene networks
  • Concepts of ultrasensitivity and its relationship to Hill function
  • Hill function, ultrasensitive response - with globally sigmoid shape
  • Inputs as physiological signals or deleterious environmental perturbations - presence sensed through receptor molecules in cell
  • Positive feedback - signaling/network motif in biological systems
  • Transducing signals in ultrasensitive manner - being multi-faceted
  • Ultrasensitive motif in biochemical networks and homo-multimerization
  • Ultrasensitive motifs - best appreciated in context of protein and gene feedback networks
  • Ultrasensitive response motifs in biochemical networks

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Zhang, Q., Bhattacharya, S., Woods, C. G., & Andersen, M. E. (2010). Ultrasensitive Response Motifs in Biochemical Networks. In Quantitative Modeling in Toxicology (pp. 199-217). John Wiley and Sons. DOI: 10.1002/9780470686263.ch9

Ultrasensitive Response Motifs in Biochemical Networks. / Zhang, Qiang; Bhattacharya, Sudin; Woods, Courtney G.; Andersen, Melvin E.

Quantitative Modeling in Toxicology. John Wiley and Sons, 2010. p. 199-217.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zhang, Q, Bhattacharya, S, Woods, CG & Andersen, ME 2010, Ultrasensitive Response Motifs in Biochemical Networks. in Quantitative Modeling in Toxicology. John Wiley and Sons, pp. 199-217. DOI: 10.1002/9780470686263.ch9
Zhang Q, Bhattacharya S, Woods CG, Andersen ME. Ultrasensitive Response Motifs in Biochemical Networks. In Quantitative Modeling in Toxicology. John Wiley and Sons. 2010. p. 199-217. Available from, DOI: 10.1002/9780470686263.ch9

Zhang, Qiang; Bhattacharya, Sudin; Woods, Courtney G.; Andersen, Melvin E. / Ultrasensitive Response Motifs in Biochemical Networks.

Quantitative Modeling in Toxicology. John Wiley and Sons, 2010. p. 199-217.

Research output: Chapter in Book/Report/Conference proceedingChapter

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